PRKCQ

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

Description

Protein kinase C theta

Tissue specificity

Group enriched (lymphoid tissue, skeletal muscle, tongue)

Subcell location

Centriolar satellite

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (6427143 - 6580301)

Ensembl ID

ENSG00000065675  (ver. 103.38)

Orthologs

Mouse Prkcq: ENSMUSG00000026778

UniProt

Q04759

neXtProt

NX_Q04759

Human splice variants
Mouse splice variants

Protein structure