Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 359302 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#359302, RRID:AB_2562682
- Product name
- Purified anti-human CD49b
- Antibody type
- Monoclonal
- Antigen
- HT1080 cells
- Description
- CD49b is a 170 kD transmembrane protein, also known as α2 integrin, VLA-2 α chain, Integrin α2 and GPIa. It associates with CD29 (β1 integrin) to form VLA-2, a collagen and laminin receptor on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. CD49b has been reported to interact with F-actin and matrix metalloproteinase 1. CD49b is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- P1E6-C5
- Vial size
- 500 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood platelets stained with purified CD49b (clone P1E6-C5) or purified mouse IgG1, κ isotype control, followed by anti-mouse IgG PE.
- Conjugate
- Unconjugated