Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 314304 - Provider product page
- Provider
- BioLegend
- Product name
- Purified anti-human CD49b
- Antibody type
- Monoclonal
- Antigen
- CD49b
- Description
- CD49b is a 170 kD transmembrane protein, also known as α2 integrin, VLA-2 α chain, Integrin α2 or GPIa. It associates with CD29 (β1 integrin) to form VLA-2, a collagen and alminin receptor on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. CD49b has been reported to interact with F-actin and matrix metalloproteinase 1. CD49b is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells.
Kirkland SC, Ying H
The Journal of biological chemistry 2008 Oct 10;283(41):27612-9
The Journal of biological chemistry 2008 Oct 10;283(41):27612-9
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