PLA2G3

This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

Description

Phospholipase A2 group III

Tissue specificity

Group enriched (esophagus, skin , vagina)

Subcell location

Endoplasmic reticulum, Golgi apparatus

Predicted location

Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

22:q12.2 (31134807 - 31140508)

Ensembl ID

ENSG00000100078  (ver. 103.38)

Orthologs

Mouse Pla2g3: ENSMUSG00000034579

UniProt

Q9NZ20

neXtProt

NX_Q9NZ20

Human splice variants
Mouse splice variants