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- Antigen structure
- References [17]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14597-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14597-1-AP, RRID:AB_2117919
- Product name
- HMGB2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HMGB2 antibody (Cat. #14597-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references HMGB2 is a biomarker associated with poor prognosis promoting radioresistance in glioma by targeting base excision repair pathway.
Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions.
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression.
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
Platinum-Based Regimens Are Active in Advanced Pediatric-Type Rhabdomyosarcoma in Adults and Depending on HMGB1 Expression.
Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart.
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
LncRNA SNHG16 accelerates atherosclerosis and promotes ox-LDL-induced VSMC growth via the miRNA-22-3p/HMGB2 axis.
Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis.
Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.
Fluoride-induced unrestored arrest during haploid period of spermatogenesis via the regulation of DDX25 in rats.
HMGB2 promotes the malignancy of human gastric cancer and indicates poor survival outcome.
HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer.
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells.
Han W, Zhou H, Zhang X, Li H, Han X, Su L, Tian L, Xue X
Translational oncology 2024 Jul;45:101977
Translational oncology 2024 Jul;45:101977
Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions.
Kwon W, Choi DJ, Yu K, Williamson MR, Murali S, Ko Y, Woo J, Deneen B
International journal of molecular sciences 2024 Jan 13;25(2)
International journal of molecular sciences 2024 Jan 13;25(2)
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
Xu M, Li F, Xu X, Hu N, Miao J, Zhao Y, Ji S, Wang Y, Wang L
Ecotoxicology and environmental safety 2024 Feb;271:115989
Ecotoxicology and environmental safety 2024 Feb;271:115989
Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression.
Guang Z, Min Z, Jun-Tan L, Tian-Xu D, Xiang G
Frontiers in immunology 2023;14:1077003
Frontiers in immunology 2023;14:1077003
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.
Huebner AJ, Gorelov RA, Deviatiiarov R, Demharter S, Kull T, Walsh RM, Taylor MS, Steiger S, Mullen JT, Kharchenko PV, Hochedlinger K
Nature cell biology 2023 Mar;25(3):390-403
Nature cell biology 2023 Mar;25(3):390-403
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
Teng S, Zhu Z, Wu C, He Y, Zhou S
International immunopharmacology 2023 Jun;119:110198
International immunopharmacology 2023 Jun;119:110198
Platinum-Based Regimens Are Active in Advanced Pediatric-Type Rhabdomyosarcoma in Adults and Depending on HMGB1 Expression.
Hindi N, Carrillo-García J, Blanco-Alcaina E, Renshaw M, Luna P, Durán J, Jiménez N, Sancho P, Ramos R, Moura DS, Martín-Broto J
International journal of molecular sciences 2023 Jan 3;24(1)
International journal of molecular sciences 2023 Jan 3;24(1)
Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart.
Cao Z, Minnier J, Liu L, Scott KLL, Reddy AP, Wilmarth PA, David LL, Barnes AP, Grafe MR, Kaul S, Alkayed NJ, Davis CM
Scientific reports 2022 May 25;12(1):8835
Scientific reports 2022 May 25;12(1):8835
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Wang F, Luo Y, Zhang L, Younis M, Yuan L
Cancer gene therapy 2022 Mar;29(3-4):292-303
Cancer gene therapy 2022 Mar;29(3-4):292-303
LncRNA SNHG16 accelerates atherosclerosis and promotes ox-LDL-induced VSMC growth via the miRNA-22-3p/HMGB2 axis.
Wang Y, Yang Y, Zhang T, Jia S, Ma X, Zhang M, Wang L, Ma A
European journal of pharmacology 2022 Jan 15;915:174601
European journal of pharmacology 2022 Jan 15;915:174601
Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis.
Zhang K, Liu D, Zhao J, Shi S, He X, Da P, You Y, You B
Cell death & disease 2021 May 28;12(6):554
Cell death & disease 2021 May 28;12(6):554
Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.
Han Y, Liang C, Manthari RK, Yu Y, Gao Y, Liu Y, Jiang S, Tikka C, Wang J, Zhang J
Chemosphere 2020 Jan;238:124650
Chemosphere 2020 Jan;238:124650
Fluoride-induced unrestored arrest during haploid period of spermatogenesis via the regulation of DDX25 in rats.
Han Y, Yu Y, Liang C, Shi Y, Zhu Y, Zheng H, Wang J, Zhang J
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:538-551
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:538-551
HMGB2 promotes the malignancy of human gastric cancer and indicates poor survival outcome.
Cui G, Cai F, Ding Z, Gao L
Human pathology 2019 Feb;84:133-141
Human pathology 2019 Feb;84:133-141
HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer.
Fu D, Li J, Wei J, Zhang Z, Luo Y, Tan H, Ren C
Cell communication and signaling : CCS 2018 Feb 20;16(1):8
Cell communication and signaling : CCS 2018 Feb 20;16(1):8
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells.
Abraham AB, Bronstein R, Chen EI, Koller A, Ronfani L, Maletic-Savatic M, Tsirka SE
Proteome science 2013 Apr 27;11(1):18
Proteome science 2013 Apr 27;11(1):18
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 14597-1-AP(HMGB2 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 14597-1-AP(HMGB2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMGB2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HMGB2. This antibody recognizes human,mouse,rat antigen. The HMGB2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
