HMGB2

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

Description

High mobility group box 2

Tissue specificity

Group enriched (bone marrow, lymphoid tissue)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (173331376 - 173334432)

Ensembl ID

ENSG00000164104  (ver. 103.38)

Orthologs

Mouse Hmgb2: ENSMUSG00000054717

UniProt

P26583

neXtProt

NX_P26583

Human splice variants
Mouse splice variants

Protein structure