CCKBR

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]

Description

Cholecystokinin B receptor

Tissue specificity

Group enriched (brain, pancreas, stomach)

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

11:p15.4 (6259806 - 6272127)

Ensembl ID

ENSG00000110148  (ver. 103.38)

Orthologs

Mouse Cckbr: ENSMUSG00000030898

UniProt

P32239

neXtProt

NX_P32239

Human splice variants
Mouse splice variants