AGTO-G003E

antibody from Creative Biolabs

Targeting: CCKBR

No application information provided.

Antibody Data

Product number

AGTO-G003E

Provider

Creative Biolabs

Product name

Anti-Cckbr immunotoxin (scFv)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-Cckbr scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to gastrin/cholecystokinin subtype 2 receptor (CCK2R) overexpressed gastric cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating gastric cancer.

Reactivity

Mouse

Host

Mouse