Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14876-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14876-1-AP, RRID:AB_2089444
- Product name
- DAAM1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DAAM1 antibody (Cat. #14876-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrated proteogenomic characterization of glioblastoma evolution.
Estrogen influences the transzonal projection assembly of cumulus-oocyte complexes through G protein-coupled estrogen receptor during goat follicle development.
Chiral growth of adherent filopodia.
Formin protein DIAPH1 positively regulates PD-L1 expression and predicts the therapeutic response to anti-PD-1/PD-L1 immunotherapy.
Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer.
The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis.
The novel role of etoposide in inhibiting the migration and proliferation of small cell lung cancer and breast cancer via targeting Daam1.
Daam1 Overexpression Promotes Gastric Cancer Progression and Regulates ERK and AKT Signaling Pathways.
Formin homology domains of Daam1 bind to Fascin and collaboratively promote pseudopodia formation and cell migration in breast cancer.
The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development.
YWHAZ interacts with DAAM1 to promote cell migration in breast cancer.
Overexpressed DAAM1 correlates with metastasis and predicts poor prognosis in breast cancer.
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
A DAAM1 3'-UTR SNP mutation regulates breast cancer metastasis through affecting miR-208a-5p-DAAM1-RhoA axis.
Divergent roles of the Wnt/PCP Formin Daam1 in renal ciliogenesis.
DAAM1-mediated migration and invasion of ovarian cancer cells are suppressed by miR-208a-5p.
Human neuroglial cells internalize Borrelia burgdorferi by coiling phagocytosis mediated by Daam1.
Formin-dependent TGF-β signaling for epithelial to mesenchymal transition.
miR-613 inhibits cell migration and invasion by downregulating Daam1 in triple-negative breast cancer.
Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH).
DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility.
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Kim KH, Migliozzi S, Koo H, Hong JH, Park SM, Kim S, Kwon HJ, Ha S, Garofano L, Oh YT, D'Angelo F, Kim CI, Kim S, Lee JY, Kim J, Hong J, Jang EH, Mathon B, Di Stefano AL, Bielle F, Laurenge A, Nesvizhskii AI, Hur EM, Yin J, Shi B, Kim Y, Moon KS, Kwon JT, Lee SH, Lee SH, Gwak HS, Lasorella A, Yoo H, Sanson M, Sa JK, Park CK, Nam DH, Iavarone A, Park JB
Cancer cell 2024 Mar 11;42(3):358-377.e8
Cancer cell 2024 Mar 11;42(3):358-377.e8
Estrogen influences the transzonal projection assembly of cumulus-oocyte complexes through G protein-coupled estrogen receptor during goat follicle development.
Xu R, Wen D, Yin L, Tang Y, Lu S, Gao Y, Pan MH, Han B, Ma B
Molecular reproduction and development 2024 Jun;91(6):e23763
Molecular reproduction and development 2024 Jun;91(6):e23763
Chiral growth of adherent filopodia.
Li W, Chung WL, Kozlov MM, Medalia O, Geiger B, Bershadsky AD
Biophysical journal 2023 Sep 19;122(18):3704-3721
Biophysical journal 2023 Sep 19;122(18):3704-3721
Formin protein DIAPH1 positively regulates PD-L1 expression and predicts the therapeutic response to anti-PD-1/PD-L1 immunotherapy.
Mei J, Cai Y, Wang H, Xu R, Zhou J, Lu J, Yang X, Pan J, Liu C, Xu J, Zhu Y
Clinical immunology (Orlando, Fla.) 2023 Jan;246:109204
Clinical immunology (Orlando, Fla.) 2023 Jan;246:109204
Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer.
Peippo M, Gardberg M, Kronqvist P, Carpén O, Heuser VD
Journal of breast cancer 2023 Dec;26(6):525-543
Journal of breast cancer 2023 Dec;26(6):525-543
The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis.
Phillips AT, Boumil EF, Venkatesan A, Tilstra-Smith C, Castro N, Knox BE, Henty-Ridilla JL, Bernstein AM
European journal of cell biology 2023 Dec;102(4):151347
European journal of cell biology 2023 Dec;102(4):151347
The novel role of etoposide in inhibiting the migration and proliferation of small cell lung cancer and breast cancer via targeting Daam1.
Yu X, Xu T, Su B, Zhou J, Xu B, Zhang Y, Zhu Y, Jiang N, He Z
Biochemical pharmacology 2023 Apr;210:115468
Biochemical pharmacology 2023 Apr;210:115468
Daam1 Overexpression Promotes Gastric Cancer Progression and Regulates ERK and AKT Signaling Pathways.
Zhang Y, Bai X, Zhang Y, Li Y
OncoTargets and therapy 2021;14:4609-4619
OncoTargets and therapy 2021;14:4609-4619
Formin homology domains of Daam1 bind to Fascin and collaboratively promote pseudopodia formation and cell migration in breast cancer.
Hao L, Liu Y, Yu X, Zhu Y, Zhu Y
Cell proliferation 2021 Mar;54(3):e12994
Cell proliferation 2021 Mar;54(3):e12994
The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development.
Krneta-Stankic V, Corkins ME, Paulucci-Holthauzen A, Kloc M, Gladden AB, Miller RK
Cell reports 2021 Jul 6;36(1):109340
Cell reports 2021 Jul 6;36(1):109340
YWHAZ interacts with DAAM1 to promote cell migration in breast cancer.
Mei J, Liu Y, Yu X, Hao L, Ma T, Zhan Q, Zhang Y, Zhu Y
Cell death discovery 2021 Aug 27;7(1):221
Cell death discovery 2021 Aug 27;7(1):221
Overexpressed DAAM1 correlates with metastasis and predicts poor prognosis in breast cancer.
Mei J, Xu B, Hao L, Xiao Z, Liu Y, Yan T, Zhu Y
Pathology, research and practice 2020 Mar;216(3):152736
Pathology, research and practice 2020 Mar;216(3):152736
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
He QJ, Wang P, Liu QQ, Wu QG, Li YF, Wang J, Lee SC
American journal of physiology. Cell physiology 2020 Jan 1;318(1):C48-C62
American journal of physiology. Cell physiology 2020 Jan 1;318(1):C48-C62
A DAAM1 3'-UTR SNP mutation regulates breast cancer metastasis through affecting miR-208a-5p-DAAM1-RhoA axis.
Mei J, Yan T, Huang Y, Xia T, Chang F, Shen S, Hao L, Chen Y, Wang Z, Jiang X, Xu B, Zhu Y
Cancer cell international 2019;19:55
Cancer cell international 2019;19:55
Divergent roles of the Wnt/PCP Formin Daam1 in renal ciliogenesis.
Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK
PloS one 2019;14(8):e0221698
PloS one 2019;14(8):e0221698
DAAM1-mediated migration and invasion of ovarian cancer cells are suppressed by miR-208a-5p.
Mei J, Huang Y, Hao L, Liu Y, Yan T, Qiu T, Xu R, Xu B, Xiao Z, Jiang X, Hu K, Zhu Y
Pathology, research and practice 2019 Jul;215(7):152452
Pathology, research and practice 2019 Jul;215(7):152452
Human neuroglial cells internalize Borrelia burgdorferi by coiling phagocytosis mediated by Daam1.
Williams SK, Weiner ZP, Gilmore RD
PloS one 2018;13(5):e0197413
PloS one 2018;13(5):e0197413
Formin-dependent TGF-β signaling for epithelial to mesenchymal transition.
Rana MK, Aloisio FM, Choi C, Barber DL
Molecular biology of the cell 2018 Jun 15;29(12):1465-1475
Molecular biology of the cell 2018 Jun 15;29(12):1465-1475
miR-613 inhibits cell migration and invasion by downregulating Daam1 in triple-negative breast cancer.
Xiong H, Yan T, Zhang W, Shi F, Jiang X, Wang X, Li S, Chen Y, Chen C, Zhu Y
Cellular signalling 2018 Apr;44:33-42
Cellular signalling 2018 Apr;44:33-42
Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH).
Yanai S, Wakayama M, Nakayama H, Shinozaki M, Tsukuma H, Tochigi N, Nemoto T, Saji T, Shibuya K
Diagnostic pathology 2017 Mar 14;12(1):25
Diagnostic pathology 2017 Mar 14;12(1):25
DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility.
Nishimura T, Ito S, Saito H, Hiver S, Shigetomi K, Ikenouchi J, Takeichi M
The Journal of cell biology 2016 Nov 21;215(4):559-573
The Journal of cell biology 2016 Nov 21;215(4):559-573
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W
Development (Cambridge, England) 2011 Jan;138(2):303-15
Development (Cambridge, England) 2011 Jan;138(2):303-15
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 14876-1-AP(DAAM1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using DAAM1 antibody 14876-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 14876-1-AP(DAAM1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 14876-1-AP(DAAM1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue