13572-1-AP

antibody from Proteintech Group

Targeting: SIRT6

Provider product page for 13572-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [75]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 13572-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13572-1-AP, RRID:AB_2188915
Product name: SIRT6 antibody
Antibody type: Polyclonal
Description: KD/KO validated SIRT6 antibody (Cat. #13572-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SIRT6 protein structure - 13572-1-AP shown in red.

Submitted references SIRT6-Mediated Regulation of TFAM: A Central Mechanism Connecting Nuclear and Mitochondrial Transcriptional Processes and Mitophagy.

Jiang M, Li J, Ding N, Jia G, Wu S, Liu N, Kang Y, Zhang G, Wu J, Zhang L, Zhang Y
International journal of biological sciences 2026;22(1):178-200

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages.

Wu Y, Ling S, Mao J, Wang H, Wang B, Che Z, Cui W, Cai M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(26):e17554

Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53.

Zhao Y, Xu T, Ye C, Zhang K, Heng X, Huang S, Chen Y, Guo Y, Shao S, Wen Z, Shao C, Lu X, Sun N, Yang H
Phytotherapy research : PTR 2026 Mar;40(3):965-985

Dissecting the differentiation origins of intestinal metaplasia and early intestinal-type gastric cancer in gastric antrum by single-cell RNA profiling.

Yin H, Zhang H, Zheng S, Guo R, Wen J, Liu M, Li A, Zhao M, Yuan Y, Gong Y
NPJ precision oncology 2026 Mar 10;10(1)

Ononin promotes bone marrow-derived mesenchymal stem cells survival via SIRT6/Nrf2 signaling for myocardial infarction repair.

Hu C, Xu T, Xu H, Pang M, Zhang G, Han X, Zhang J, Liu M, Hua Y, Chen G, Zhong B, Deng B, Tu Y, Chen T, Hu S, Liu B, Zhou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157514

AnnoNet-TCMs: An annotation network-driven discovery of novel active compounds and mechanisms in traditional Chinese medicine.

Yan X, Guo Z, Zhou F, Cui Y, Zhang Z, Jing Z, Wang L, Fan Z, Lu J, Xing X, Yang H
Journal of advanced research 2026 Apr 5;

Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.

Jiang Y, Shi Y, Lv M, Wang T, Wang P, Yuan X, Gao F, Ma B
Cell biology and toxicology 2025 Sep 2;41(1):129

Geniposidic acid alleviated metabolic dysfunction-associated steatotic liver disease by exciting SIRT6 signaling.

Zhou Y, Feng M, Hai H, Teng X, Zhou X, Gao Y, Zhong Y, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157140

LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region.

Li M, Gao Y, Sun X, Zheng W, Zhang M, Wang C, Chu W, Yang X, Wang L, Zheng M, Xue W, Dong F, Pei D, Liao M
Cellular & molecular biology letters 2025 Oct 6;30(1):115

Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.

Jiang Y, Lv M, Fan H, Shi Y, Wang T, Wang P, Yuan X, Gao F, Ma B
Animal models and experimental medicine 2025 Nov;8(11):2053-2068

PRMT1 Upregulates SIRT6 by Enhancing Arginine Methylation of E2F7 to Inhibit Vascular Smooth Muscle Cell Senescence in Aortic Dissection.

Wu Y, Qin X, Xiang M, Deng J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70579

High energy diet-induced prediabetic neuropathic pain is mediated by reduction of SIRT6 negative control of both spinal and peripheral neuroinflammation.

Yang Y, Sun W, Yang F, Liang T, Li CL, Wang Y, Wang XL, Wang RR, Wu SC, Chen J
Neuroscience 2025 Mar 17;569:58-66

SIRT6 mitigates acute kidney injury by enhancing lipid metabolism and reducing tubular epithelial cell apoptosis via suppression of the ACMSD signaling pathway.

Wang D, Zhou Y, Yang N, Liu J, Lu L, Gao Z
Cellular signalling 2025 Jul;131:111757

Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota.

Yang Q, He WH, Xie L, Chen T, Liu RF, Hu JJ, Guo JY, Tan GZ, Wu FL, Gu P, Chen P, Chen Y
Acta pharmacologica Sinica 2025 Feb;46(2):416-429

SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.

Shi J, Chen L, Wang X, Ma X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 10;74(1):35

SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation.

Wei L, Kang M, Zhang G, Meng Y, Qin H
Inflammation 2025 Dec;48(6):3858-3877

Inhibitory Effect of Sirtuin6 on EndMT by Regulating Oxidative Stress and Autophagy in Coxsackievirus B3-Induced Cardiac Endothelial Cells.

Yang Z, Wang Y, Chen J, Shou X, Zhang D, Zhou Z, Liu Q
Immunity, inflammation and disease 2025 Dec;13(12):e70316

Lysophosphatidylethanolamine 18:1 drives clear cell renal cell carcinoma by stabilizing SIRT6 to reprogram lipid metabolism.

Yue N, Zhao H, Zhang Y, Gu J, Qi J, Wen J, Wang W, Lv M, Sun H, Chen J, Yang C, Qu C, Chen X, Yang Z
Signal transduction and targeted therapy 2025 Dec 8;10(1):398

IL-1β-stimulated bone mesenchymal stem cell-derived exosomes promote cutaneous wound healing by inhibiting SIRT6/NLRP3 pathway.

Li R, Fan X, He Z, Shen H, Wu H, Chen J, Peng L, Liang B, Feng C, Zhu H
International immunopharmacology 2025 Dec 3;166:115566

Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis.

Yu JT, Xie SS, Shen XY, Li Z, Hu XW, Zhang Y, Dong ZH, Wang JN, Li XY, Dong YH, Li C, Ji ML, Suo XG, Yang C, Jin J, Wang W, Wen JG, Liu MM, Li L, Yang Q, Meng XM
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Aug 6;33(8):3757-3777

Ubiquitin-specific peptidase 10 attenuates bleomycin-induced pulmonary fibrosis via modulating autophagy depending on sirtuin 6-mediated AKT/mTOR.

Mao S, Yu N, Wang W, Mao Y, Du Y, Zhao Q, Gu X, Kang J
Cell biology and toxicology 2025 Apr 25;41(1):73

Comprehensive Analysis of the Prognostic Implications and Biological Function of HDACs in Liver Hepatocellular Carcinoma.

Cui Z, Zheng C, You Y, He S, Jiang S, Chen Y, Lin Y, Xiao Z
International journal of medical sciences 2024;21(14):2807-2823

MitoAMPK inhibits the Warburg effect by MZF1-SIRT6 with glycosis related genes in NSCLC.

Li S, He J, Zhang L, Zhao Q, Zhao S, Jiang S
Journal of cellular and molecular medicine 2024 Sep;28(17):e70053

LINC00887 promotes GCN5-dependent H3K27cr level and CRC metastasis via recruitment of YEATS2 and enhancing ETS1 expression.

Liao M, Zheng W, Wang Y, Li M, Sun X, Liu N, Yao J, Dong F, Wang Q, Ma Y, Mou J
Cell death & disease 2024 Sep 30;15(9):711

A Novel Prognostic Model of Hepatocellular Carcinoma per Two NAD+ Metabolic Synthesis-Associated Genes.

Dai L, Lu S, Mao L, Zhong M, Feng G, He S, Yuan G
International journal of molecular sciences 2024 Sep 26;25(19)

Lactylation of RNA m(6)A demethylase ALKBH5 promotes innate immune response to DNA herpesviruses and mpox virus.

Li W, Zhou J, Gu Y, Chen Y, Huang Y, Yang J, Zhu X, Zhao K, Yan Q, Zhao Z, Li X, Chen G, Jia X, Gao SJ, Lu C
Proceedings of the National Academy of Sciences of the United States of America 2024 Oct 22;121(43):e2409132121

Exploring the anti-ovarian aging mechanism of He's Yangchao formula: Insights from multi-omics analysis in naturally aged mice.

Yang L, Lai X, Jin S, Wang H, Lin F, Jin X, Chen Y, Wang R, Huang Y, Zhang Y, Tian S, Fang X, Duan X, Zhang Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155961

KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.

Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082

Integrated Transcriptomic and Proteomic Study of the Mechanism of Action of the Novel Small-Molecule Positive Allosteric Modulator 1 in Targeting PAC1-R for the Treatment of D-Gal-Induced Aging Mice.

Liang L, Chen S, Su W, Zhang H, Yu R
International journal of molecular sciences 2024 Mar 30;25(7)

Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.

Kong W, Chen J, Ruan X, Xu X, Li X, Bao M, Shao Y, Bian X, Li R, Jiang Q, Zhang Y, Li Z, Yan F, Ye J
Life sciences 2024 Mar 15;341:122474

ADSCs encapsulated in Gelatin methacrylate substrate promotes the repair of peripheral nerve injury by SIRT6/PGC-1α pathway.

Xiang Y, Li X, Huang Y, Gao S, Wei P, Wu L, Dong J
Regenerative therapy 2024 Jun;26:671-682

Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.

Qu H, Liu X, Zhu J, He N, He Q, Zhang L, Wang Y, Gong X, Xiong X, Liu J, Wang C, Yang G, Yang Q, Luo G, Zhu Z, Zheng Y, Zheng H
iScience 2024 Jun 21;27(6):109796

Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma.

Sripodok P, Saito H, Kouketsu A, Takahashi T, Kumamoto H
Odontology 2024 Jan;112(1):221-229

Sirt6 ameliorates high glucose-induced podocyte cytoskeleton remodeling via the PI3K/AKT signaling pathway.

Zhang Z, Huang H, Tao Y, Liu H, Fan Y
Renal failure 2024 Dec;46(2):2410396

Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.

Du L, Guo C, Zeng S, Yu K, Liu M, Li Y
Renal failure 2024 Dec;46(2):2377785

Astragaloside IV Inhibited Podocyte Pyroptosis in Diabetic Kidney Disease by Regulating SIRT6/HIF-1α Axis.

Zhang M, Liu W, Liu Y, Zhang Z, Hu Y, Sun D, Li S, Fang J
DNA and cell biology 2023 Oct;42(10):594-607

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.

Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626

SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.

Yang J, Chen X
Immunity, inflammation and disease 2023 Mar;11(3):e809

N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185

Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells.

Zhang JX, Bao SC, Chen J, Chen T, Wei HL, Zhou XY, Li JT, Yan SG
World journal of gastrointestinal oncology 2023 Mar 15;15(3):464-489

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery.

Wang Y, Cai Z, Zhan G, Li X, Li S, Wang X, Li S, Luo A
Antioxidants (Basel, Switzerland) 2023 Mar 13;12(3)

Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders.

Pan ZS, Chen YL, Tang KJ, Liu ZZ, Liang JL, Guan YH, Xin XY, Liu CH, Shen CP
Experimental and therapeutic medicine 2023 Jul;26(1):320

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.

Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114048

Inhibition of the AKT1/mTOR pathway through SIRT6 over expression downregulated the expression of programmed death-ligand 1 and prolonged overall survival in lung adenocarcinoma.

Yuan ZF, Lin YD, Wu GS, Li L, Yang JP, Zhang JW
Annals of translational medicine 2023 Jan 15;11(1):21

FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6.

Wang R, Wang J, Zhang Z, Ma B, Sun S, Gao L, Gao G
Molecular medicine (Cambridge, Mass.) 2023 Dec 4;29(1):165

Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity.

Xiao X, Hu H, Zhong Y, Chen Y, Tang K, Pan Z, Huang J, Yang X, Wang Q, Gao Y
Molecular medicine (Cambridge, Mass.) 2023 Aug 15;29(1):108

Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity.

Liu C, Pan Z, Wu Z, Tang K, Zhong Y, Chen Y, Xiao X, Guo J, Duan S, Cui T, Zhong G, Yang Z, Zhong C, Lin S, Gao Y
Cellular and molecular gastroenterology and hepatology 2022;14(2):271-293

SIRT6 Activator UBCS039 Inhibits Thioacetamide-Induced Hepatic Injury In Vitro and In Vivo.

Jiao F, Zhang Z, Hu H, Zhang Y, Xiong Y
Frontiers in pharmacology 2022;13:837544

Reduction of H3K27cr Modification During DNA Damage in Colon Cancer.

Liao M, Chu W, Sun X, Zheng W, Gao S, Li D, Pei D
Frontiers in oncology 2022;12:924061

Selective transportation and energy homeostasis regulation of dietary advanced glycation end-products in human intestinal Caco-2 cells.

Wu Y, Zong M, Zhang Z, Wu Y, Li L, Zhang X, Wu H, Li B
Food chemistry 2022 Oct 15;391:133284

A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.

Xiao M, Tang Y, Wang J (a), Lu G, Niu J, Wang J (b), Li J, Liu Q, Wang Z, Huang Z, Guo Y, Gao T, Zhang X, Yue S, Gu J
Redox biology 2022 Feb;49:102219

Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD-Induced Insulin Resistance by Modulating IRS-1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways.

Wu R, Jian T, Ding X, Lv H, Meng X, Ren B, Li J, Chen J, Li W
Oxidative medicine and cellular longevity 2021;2021:4706410

Bioinformatics Analysis of the SIRT Family Members and Assessment of Their Potential Clinical Value.

Liu M, Yu J, Jin H, Wang S, Ding J, Xing H, He S, Zeng Y
OncoTargets and therapy 2021;14:2635-2649

Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335

Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.

Zhang Y, Yang Z, Xu Z, Wan J, Hua T, Sun Q
Canadian journal of physiology and pharmacology 2021 May;99(5):506-511

Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.

Tang Q, Liu Q, Yang X, Wu T, Huang C, Zhang J, Zhang Z, Zhang G, Zhao Y, Zhou J, Huang H, Xia Y, Yan J, Li Y, He J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21408

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.

Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL
Nature communications 2021 Jan 4;12(1):51

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.

Fang C, Liu Y, Chen L, Luo Y, Cui Y, Zhang N, Liu P, Zhou M, Xie Y
Pharmaceutical biology 2021 Dec;59(1):11-20

Zhao Y, Bai X, Jia X, Lu Y, Cheng W, Shu M, Zhu Y, Zhu L, Wang L, Shu Y, Song Y, Jin S
BMC geriatrics 2021 Aug 4;21(1):452

Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.

Cao Y, Hu G, Zhang Q, Ma L, Wang J, Li W, Ge Y, Cheng J, Yang Z, Fu S, Liu J
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.

Wei W, Guo X, Gu L, Jia J, Yang M, Yuan W, Rong S
Stem cell research & therapy 2021 Apr 13;12(1):235

The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.

Yang Z, Huang R, Wei X, Yu W, Min Z, Ye M
Frontiers in oncology 2020;10:1265

The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.

Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Cell biochemistry and function 2020 Mar;38(2):130-140

Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.

He Q, Chen K, Ye R, Dai N, Guo P, Wang L
Oncology letters 2020 Apr;19(4):3278-3288

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.

Yang Z, Yu W, Huang R, Ye M, Min Z
Cancer cell international 2019;19:17

SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.

Yu W, Yang Z, Huang R, Min Z, Ye M
OncoTargets and therapy 2019;12:2861-2868

Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.

Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879

Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.

Yang H, Zhu R, Zhao X, Liu L, Zhou Z, Zhao L, Liang B, Ma W, Zhao J, Liu J, Huang G
Oncogene 2019 Jun;38(25):4915-4931

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.

Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538

The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.

Liu Y, Li Y, Huang ZN, Wang ZY, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Connective tissue research 2019 Jul;60(4):376-388

Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism.

Pan XH, Chen YH, Yang YK, Zhang XJ, Lin QK, Li ZA, Cai XM, Pang RQ, Zhu XQ, Ruan GP
Aging 2019 Jan 23;11(2):590-614

Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.

Li N, Mao D, Cao Y, Li H, Ren F, Li K
International journal of oncology 2018 May;52(5):1515-1527

Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs.

Feng Y, Liang J, Zhai Y, Sun J, Wang J, She X, Gu Q, Liu Y, Zhu H, Luo X, Sun X
Biochemical and biophysical research communications 2018 Feb 19;496(4):1148-1154

The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.

Sun HL, Wu YR, Huang C, Wang JW, Fu DJ, Liu YC
Journal of endodontics 2014 Mar;40(3):393-8

SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

Sun H, Wu Y, Fu D, Liu Y, Huang C
Stem cells (Dayton, Ohio) 2014 Jul;32(7):1943-55

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 13572-1-AP(SIRT6 antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 13572-1-AP(SIRT6 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SIRT6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT6. This antibody recognizes human, mouse, rat antigen. The SIRT6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13572-1-AP.pdf

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