Tissue expression
Cell line expression
Protein structure

PPM1A

Protein phosphatase, Mg2+/Mn2+ dependent 1A
MGC9201, PP2CA, PP2Calpha 
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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508 antibodies from 38 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
15 antibodies
Cell Signaling Technology, Inc
1 antibody
Novus Biologicals
45 antibodies
antibodies-online
166 antibodies
GeneTex
6 antibodies
Abnova Corporation
5 antibodies
Biorbyt
55 antibodies
OriGene
4 antibodies
Atlas Antibodies
1 antibody
HUABIO Research
1 antibody
Acris Antibodies GmbH
16 antibodies
Bioworld Technology, Inc
1 antibody
Boster Biological Technology
1 antibody
Proteintech Group
1 antibody
NovoPro Bioscience Inc.
4 antibodies
Cusabio Biotech Co., Ltd
2 antibodies
Affinity Biosciences
1 antibody
St John's Laboratory
1 antibody
RabMAbs
4 antibodies
Abgent
4 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Aviva Systems Biology
2 antibodies
Creative Diagnostics
8 antibodies
ProSci
2 antibodies
R&D Systems
1 antibody
United States Biological
41 antibodies
MyBioSource
8 antibodies
Sino Biological Inc.
6 antibodies
Abbexa
6 antibodies
BioLegend
2 antibodies
EMD Millipore
1 antibody
RayBiotech, Inc.
1 antibody
Leading Biology
4 antibodies
GenWay
1 antibody
Creative Biolabs
10 antibodies