PPM1A

gene product
MGC9201, PP2CA, PP2Calpha
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
21 antibodies
Cell Signaling Technology, Inc
1 antibody
antibodies-online
166 antibodies
GeneTex
6 antibodies
Abnova Corporation
5 antibodies
Invitrogen Antibodies
5 antibodies
Biorbyt
25 antibodies
Atlas Antibodies
1 antibody
Acris Antibodies GmbH
16 antibodies
Bioworld Technology, Inc
1 antibody
NovoPro Bioscience Inc.
4 antibodies
LifeSpan BioSciences, Inc.
45 antibodies
Affinity Biosciences
1 antibody
OriGene
4 antibodies
RabMAbs
4 antibodies
Abgent
4 antibodies
St John's Laboratory
1 antibody
Creative Biolabs
8 antibodies
Proteintech Group
1 antibody
Aviva Systems Biology
2 antibodies
ProSci
2 antibodies
R&D Systems
1 antibody
United States Biological
41 antibodies
MyBioSource
8 antibodies
Sino Biological Inc.
6 antibodies
Creative Diagnostics
8 antibodies
EMD Millipore
1 antibody
RayBiotech, Inc.
1 antibody
GenWay
1 antibody