orb107116

antibody from Biorbyt
Targeting: TICAM1 MGC35334, PRVTIRB, TICAM-1, TRIF
Provider product page for orb107116
Western blot

Antibody data

Product number
orb107116 - Provider product page
Provider
Biorbyt
Product name
TICAM1 antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to TICAM1. TIR domain-containing adapter molecule 1 (TICAM1) is Involved in innate immunity against invading pathogens. TICAM1 is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1; which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD, respectively. TICAM1 is ubiquitously expressed with higher levels observed in liver.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 ul
Storage
-20°C
TICAM1 protein structure - orb107116 shown in red.