M6PR

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]

Description

Mannose-6-phosphate receptor, cation dependent

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

12 (8940361 - 8949761)

Ensembl ID

ENSG00000003056  (ver. 103.38)

Orthologs

Mouse M6pr: ENSMUSG00000007458

UniProt

P20645

neXtProt

NX_P20645

Human splice variants
Mouse splice variants

Protein structure