OPRK1

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Description

Opioid receptor kappa 1

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

8 (53225724 - 53251637)

Ensembl ID

ENSG00000082556  (ver. 103.38)

Orthologs

Mouse Oprk1: ENSMUSG00000025905

UniProt

P41145

neXtProt

NX_P41145

Human splice variants
Mouse splice variants

Protein structure