Tissue expression
Cell line expression
Protein structure

F10

Coagulation factor X
 
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
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761 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
24 antibodies
antibodies-online
192 antibodies
Novus Biologicals
59 antibodies
Biorbyt
89 antibodies
Invitrogen Antibodies
27 antibodies
Aviva Systems Biology
6 antibodies
OriGene
21 antibodies
R&D Systems
2 antibodies
Signalway Antibody LLC
1 antibody
St John's Laboratory
4 antibodies
Cusabio Biotech Co., Ltd
6 antibodies
Proteintech Group
2 antibodies
Affinity Biosciences
1 antibody
ProSci
4 antibodies
Bioworld Technology, Inc
2 antibodies
Acris Antibodies GmbH
9 antibodies
Arigo
1 antibody
Abbkine Scientific Co.Ltd.
2 antibodies
MyBioSource
25 antibodies
Creative Diagnostics
16 antibodies
RabMAbs
2 antibodies
United States Biological
37 antibodies
RayBiotech, Inc.
2 antibodies
Creative Biolabs
49 antibodies
Molecular Innovations
10 antibodies
Abbexa
8 antibodies
Green Mountain Antibodies
3 antibodies
GenWay
5 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
Leading Biology
2 antibodies
Abnova Corporation
11 antibodies
Abgent
2 antibodies
Sino Biological Inc.
1 antibody