MATK

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Megakaryocyte-associated tyrosine kinase

Tissue specificity

Tissue enhanced (bone marrow, brain)

Subcell location

Microtubules, Cytokinetic bridge, Mitotic spindle, Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (3777970 - 3802129)

Ensembl ID

ENSG00000007264  (ver. 103.38)

Orthologs

Mouse Matk: ENSMUSG00000004933

UniProt

P42679

neXtProt

NX_P42679

Human splice variants
Mouse splice variants

Protein structure