SLC30A4

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]). [supplied by OMIM, Mar 2008]

Description

Solute carrier family 30 member 4

Tissue specificity

Tissue enriched (prostate)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

15 (45479606 - 45522755)

Ensembl ID

ENSG00000104154  (ver. 103.38)

Orthologs

Mouse Slc30a4: ENSMUSG00000005802

UniProt

O14863

neXtProt

NX_O14863

Human splice variants
Mouse splice variants

Protein structure