SKAP1

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

Description

Src kinase associated phosphoprotein 1

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (48133442 - 48430275)

Ensembl ID

ENSG00000141293  (ver. 103.38)

Orthologs

Mouse Skap1: ENSMUSG00000057058

UniProt

Q86WV1

neXtProt

NX_Q86WV1

Human splice variants
Mouse splice variants

Protein structure