HPA023881

antibody from Atlas Antibodies

Targeting: TFE3 bHLHe33, TFEA

Provider product page for HPA023881

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [104]
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Validations [0]

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Product number: HPA023881 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA023881, RRID:AB_1857931
Product name: Anti-TFE3
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human TFE3, Gene description: transcription factor binding to IGHM enhancer 3, Alternative Gene Names: bHLHe33, TFEA, Validated applications: IHC, Uniprot ID: P19532, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

TFE3 protein structure - HPA023881 shown in red.

Submitted references HIF1α Plays a Crucial Role in the Development of TFE3–Rearranged Renal Cell Carcinoma by Orchestrating a Metabolic Shift Toward Fatty Acid Synthesis

Nishizawa H, Funasaki S, Ma W, Kubota Y, Watanabe K, Arima Y, Kuroda S, Ito T, Furuya M, Motoshima T, Nishiyama A, Mehanna S, Satou Y, Hasumi H, Jikuya R, Makiyama K, Tamura T, Oike Y, Tanaka Y, Suda T, Schmidt L, Linehan W, Baba M, Kamba T
Genes to Cells 2025;30(1)

Comprehensive molecular characterization of TFE3-rearranged renal cell carcinoma

Lee C, Suh J, Jang D, Jin B, Cho J, Lee M, Sim H, Kang M, Lee J, Park J, Lee K, Hwang G, Moon K, Song C, Ku J, Kwak C, Kim H, Cho S, Choi M, Jeong C
Experimental & Molecular Medicine 2024;56(8):1807-1815

TET activity safeguards pluripotency throughout embryonic dormancy

Stötzel M, Cheng C, IIik I, Kumar A, Omgba P, van der Weijden V, Zhang Y, Vingron M, Meissner A, Aktaş T, Kretzmer H, Bulut-Karslioğlu A
Nature Structural & Molecular Biology 2024;31(10):1625-1639

TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress

Jeong E, Willett R, Rissone A, La Spina M, Puertollano R
Nature Communications 2024;15(1)

Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation

Oliveira A, Memme J, Wong J, Hood D
Skeletal Muscle 2024;14(1)

Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy

Iyer D, Moyon L, Wittler L, Cheng C, Ringeling F, Canzar S, Marsico A, Bulut-Karslioğlu A
Genome Research 2024

Zhu X, Wu Y, Li Y, Zhou X, Watzlawik J, Chen Y, Raybuck A, Billadeau D, Shapiro V, Springer W, Sun J, Boothby M, Zeng H
2024

Zeng H, Zhu X, Wu Y, Li Y, Zhou X, Watzlawik J, Chen Y, Raybuck A, Billadeau D, Shapiro V, Springer W, Jie S, Boothby M
2024

Avelar R, Gupta R, Carvette G, Leprevost F, Colina J, Teitel J, Nesvizhskii A, O'connor C, Hatzoglou M, Shenolikar S, Arvan P, Narla G, DiFeo A
2024

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

Nardone C, Palanski B, Scott D, Timms R, Barber K, Gu X, Mao A, Leng Y, Watson E, Schulman B, Cole P, Elledge S
Molecular Cell 2023;83(1):57-73.e9

Reprogramming tumour-associated macrophages to outcompete cancer cells

Zhang X, Li S, Malik I, Do M, Ji L, Chou C, Shi W, Capistrano K, Zhang J, Hsu T, Nixon B, Xu K, Wang X, Ballabio A, Schmidt L, Linehan W, Li M
Nature 2023;619(7970):616-623

BCL2 is a major regulator of haploidy maintenance in murine embryonic stem cells

Sun S, Zhao Q, Zhao Y, Geng M, Wang Q, Gao Q, Zhang X, Zhang W, Shuai L
Cell Proliferation 2023;56(12)

Invading Bacterial Pathogens Activate Transcription Factor EB in Epithelial Cells through the Amino Acid Starvation Pathway of mTORC1 Inhibition

Cabral-Fernandes L, Goyal S, Farahvash A, Tsalikis J, Philpott D, Girardin S
Molecular and Cellular Biology 2023;42(9)

Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

Contreras P, Tapia P, Jeong E, Ghosh S, Altan-Bonnet N, Puertollano R
iScience 2023;26(3):106169

Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH

Itoh M, Tamura A, Kanai S, Tanaka M, Kanamori Y, Shirakawa I, Ito A, Oka Y, Hidaka I, Takami T, Honda Y, Maeda M, Saito Y, Murata Y, Matozaki T, Nakajima A, Kataoka Y, Ogi T, Ogawa Y, Suganami T
Journal of Experimental Medicine 2023;220(11)

TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation

Lin W, Li Z, Liang G, Zhou R, Zheng X, Tao R, Huo Q, Su C, Li M, Xu N, Tang C, Song J
Journal of Neuroinflammation 2023;20(1)

Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress

Dang T, Kim M, Lee Y, Le H, Kim K, Nam S, Hyun S, Kim H, Chung S, Chung H, Jho E, Yoshida H, Kim K, Park C, Lee M, Back S
Autophagy 2023;19(7):2111-2142

Bat pluripotent stem cells reveal unusual entanglement between host and viruses

Déjosez M, Marin A, Hughes G, Morales A, Godoy-Parejo C, Gray J, Qin Y, Singh A, Xu H, Juste J, Ibáñez C, White K, Rosales R, Francoeur N, Sebra R, Alcock D, Volkert T, Puechmaille S, Pastusiak A, Frost S, Hiller M, Young R, Teeling E, García-Sastre A, Zwaka T
Cell 2023;186(5):957-974.e28

Bexarotene improves motor function after spinal cord injury in mice

Wang X, Shen Z, Zhang H, Zhang H, Li F, Yu L, Chen H, Zhou K, Xu H, Sheng S
Neural Regeneration Research 2023;18(12):2733-2742

Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures

Moya-Jódar M, Ullate-Agote A, Barlabé P, Rodríguez-Madoz J, Abizanda G, Barreda C, Carvajal-Vergara X, Vilas-Zornoza A, Romero J, Garate L, Agirre X, Coppiello G, Prósper F, Aranguren X
Stem Cell Reports 2023;18(1):64-80

A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3

Ta A, Ricci-Azevedo R, Vasudevan S, Wright S, Kumari P, Havira M, Surendran Nair M, Rathinam V, Vanaja S
Nature Communications 2023;14(1)

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

Berquez M, Chen Z, Festa B, Krohn P, Keller S, Parolo S, Korzinkin M, Gaponova A, Laczko E, Domenici E, Devuyst O, Luciani A
Nature Communications 2023;14(1)

Tau accumulation in degradative organelles is associated to lysosomal stress

Piovesana E, Magrin C, Ciccaldo M, Sola M, Bellotto M, Molinari M, Papin S, Paganetti P
Scientific Reports 2023;13(1)

Clinical and pathological heterogeneity of four common fusion subtypes in Xp11.2 translocation renal cell carcinoma

Guo W, Zhu Y, Pu X, Guo H, Gan W
Frontiers in Oncology 2023;13

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

Detraux D, Caruso M, Feller L, Fransolet M, Meurant S, Mathieu J, Arnould T, Renard P
eLife 2023;12

Germline- and Somatic-Inactivating FLCN Variants in Parathyroid Cancer and Atypical Parathyroid Tumors

Jha S, Welch J, Tora R, Lack J, Warner A, del Rivero J, Sadowski S, Nilubol N, Schmidt L, Linehan W, Weinstein L, Simonds W, Agarwal S
The Journal of Clinical Endocrinology & Metabolism 2023;108(10):2686-2698

TFEB-dependent lysosome biogenesis is required for senescence.

Curnock R, Yalci K, Palmfeldt J, Jäättelä M, Liu B, Carroll B
The EMBO journal 2023 May 2;42(9):e111241

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.

Carling PJ, Ryan BJ, McGuinness W, Kataria S, Humble SW, Milde S, Duce JA, Kapadia N, Zuercher WJ, Davis JB, Di Daniel E, Wade-Martins R
Autophagy 2023 Feb;19(2):692-705

Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts.

Lopes E, Machado-Oliveira G, Simões CG, Ferreira IS, Ramos C, Ramalho J, Soares MIL, Melo TMVDPE, Puertollano R, Marques ARA, Vieira OV
Cells 2023 Dec 13;12(24)

Zheng W, Chang I, Limberis J, Budzik J, Zha B, Howard Z, Chen L, Ernst J
2023

Aufiero M, Shlezinger N, Gjonbalaj M, Mills K, Ballabio A, Hohl T
2023

Feng T, Du H, Hu F
2023

PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity

Hasegawa J, Tokuda E, Yao Y, Sasaki T, Inoki K, Weisman L, Parton R
Molecular Biology of the Cell 2022;33(3)

Stabilization of hESCs in two distinct substates along the continuum of pluripotency

Dekel C, Morey R, Hanna J, Laurent L, Ben-Yosef D, Amir H
iScience 2022;25(12):105469

Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis

Chao X, Wang S, Hlobik M, Ballabio A, Ni H, Ding W
The American Journal of Pathology 2022;192(1):87-103

Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

Akwa Y, Di Malta C, Zallo F, Gondard E, Lunati A, Diaz-de-Grenu L, Zampelli A, Boiret A, Santamaria S, Martinez-Preciado M, Cortese K, Kordower J, Matute C, Lozano A, Capetillo-Zarate E, Vaccari T, Settembre C, Baulieu E, Tampellini D
Autophagy 2022;19(2):660-677

A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT

Yang J, Xu H, Zhang C, Yang X, Cai W, Chen X
Autophagy 2022;19(2):544-550

TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes

Kao C, Su T, Huang W, Lu X, Jane W, Huang C, Huang H, Wang W
Autophagy 2022;18(12):2830-2850

The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3

Jeong E, Martina J, Contreras P, Lee J, Puertollano R
Autophagy 2022;18(10):2333-2349

Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy

Wang S, Wang G, Wu W, Xu Z, Yang J, Cao M, Wang Q, Wang J, Yang C, Zhang W
Frontiers in Immunology 2022;13

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS–MAPK Pathway Inhibition in Pancreatic Cancer

Ravichandran M, Hu J, Cai C, Ward N, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey C, Yang Y, Desousa B, Rademaker G, Staes A, Cakir Z, Jain I, Aguirre A, Mancias J, Shen Y, DeNicola G, Perera R
Cancer Discovery 2022;12(9):2198-2219

The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle

Triolo M, Oliveira A, Kumari R, Hood D
Skeletal Muscle 2022;12(1)

MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function

Hikita T, Uehara R, Itoh R, Mitani F, Miyata M, Yoshida T, Yamaguchi R, Oneyama C
Cancer Science 2022;113(4):1264-1276

Tfeb-Mediated Transcriptional Regulation of Autophagy Induces Autosis during Ischemia/Reperfusion in the Heart

Nah J, Sung E, Zhai P, Zablocki D, Sadoshima J
Cells 2022;11(2):258

TFE3-Mediated Autophagy is Involved in Dopaminergic Neurodegeneration in Parkinson’s Disease

He X, Xie Y, Zheng Q, Zhang Z, Ma S, Li J, Li M, Huang Q
Frontiers in Cell and Developmental Biology 2021;9

GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

Goodwin J, Walkup W, Hooper K, Li T, Kishi-Itakura C, Ng A, Lehmberg T, Jha A, Kommineni S, Fletcher K, Garcia-Fortanet J, Fan Y, Tang Q, Wei M, Agrawal A, Budhe S, Rouduri S, Baird D, Saunders J, Kiselar J, Chance M, Ballabio A, Appleton B, Brumell J, Florey O, Murphy L
Science Advances 2021;7(40)

A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

Du H, Wong M, Zhang T, Santos M, Hsu C, Zhang J, Yu H, Luo W, Hu F
Life Science Alliance 2021;4(7):e202000874

The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency

Olivieri D, Paramanathan S, Bardet A, Hess D, Smallwood S, Elling U, Betschinger J
Journal of Biological Chemistry 2021;297(2):100947

Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response

Chen T, Huang B, Tang T, Chao Y, Xiao X, Lee P, Yang L, Wang C
Cell Death & Differentiation 2021;28(6):1865-1879

GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice

van der Lienden M, Aten J, Marques A, Waas I, Larsen P, Claessen N, van der Wel N, Ottenhoff R, van Eijk M, Aerts J
International Journal of Molecular Sciences 2021;22(5):2532

NRF‑1 directly regulates TFE3 and promotes the proliferation of renal cancer cells

Zhuang W, Dong X, Wang B, Liu N, Guo H, Zhang C, Gan W
Oncology Letters 2021;22(3)

GDF‐11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3‐Mediated Autophagy Augmentation

Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H, Ke X
Oxidative Medicine and Cellular Longevity 2021;2021(1)

A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS

Najibi M, Honwad H, Moreau J, Becker S, Irazoqui J
Autophagy 2021;18(1):124-141

Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis

El-Houjeiri L, Biondini M, Paquette M, Kuasne H, Pacis A, Park M, Siegel P, Pause A
Journal of Clinical Investigation 2021;131(22)

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Alesi N, Akl E, Khabibullin D, Liu H, Nidhiry A, Garner E, Filippakis H, Lam H, Shi W, Viswanathan S, Morroni M, Ferguson S, Henske E
Nature Communications 2021;12(1)

Role of the V1G1 subunit of V-ATPase in breast cancer cell migration

De Luca M, Romano R, Bucci C
Scientific Reports 2021;11(1)

High-throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming

Gao Q, Zhang W, Zhao Y, Tian Y, Wang Y, Zhang J, Geng M, Xu M, Yao C, Wang H, Li L, Liu Y, Shuai L
Stem Cells Translational Medicine 2021;10(5):743-755

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

Merritt N, Garcia K, Rajendran D, Lin Z, Zhang X, Mitchell K, Borcherding N, Fullenkamp C, Chimenti M, Gingras A, Harvey K, Tanas M
eLife 2021;10

Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells.

Glykofridis IE, Knol JC, Balk JA, Westland D, Pham TV, Piersma SR, Lougheed SM, Derakhshan S, Veen P, Rooimans MA, van Mil SE, Böttger F, Poddighe PJ, van de Beek I, Drost J, Zwartkruis FJ, de Menezes RX, Meijers-Heijboer HE, Houweling AC, Jimenez CR, Wolthuis RM
eLife 2021 Jan 18;10

A conserved cysteine‐based redox mechanism sustains TFEB/HLH‐30 activity under persistent stress

Martina J, Guerrero‐Gómez D, Gómez‐Orte E, Antonio Bárcena J, Cabello J, Miranda‐Vizuete A, Puertollano R
The EMBO Journal 2020;40(3)

MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B

Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno F, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh L, Huebner A, Cesana M, Bonn F, Polishchuk E, Hübner C, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C
The EMBO Journal 2020;39(17)

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

Yang C, Zhu Z, Tong B, Iyaswamy A, Xie W, Zhu Y, Sreenivasmurthy S, Senthilkumar K, Cheung K, Song J, Zhang H, Li M
Redox Biology 2020;32

Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, Perli S, Conklin B, Yamanaka S
Cell Reports 2020;31(9):107715

A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity

Endoh M, Baba M, Endoh T, Hirayama A, Nakamura-Ishizu A, Umemoto T, Hashimoto M, Nagashima K, Soga T, Lang M, Schmidt L, Linehan W, Suda T
Cell Reports 2020;30(6):1823-1834.e5

Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells

Rohani L, Borys B, Razian G, Naghsh P, Liu S, Johnson A, Machiraju P, Holland H, Lewis I, Groves R, Toms D, Gordon P, Li J, So T, Dang T, Kallos M, Rancourt D
Communications Biology 2020;3(1)

Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from Hematopoietic Cells

Hiramoto T, Tahara M, Liao J, Soda Y, Miura Y, Kurita R, Hamana H, Inoue K, Kohara H, Miyamoto S, Hijikata Y, Okano S, Yamaguchi Y, Oda Y, Ichiyanagi K, Toh H, Sasaki H, Kishi H, Ryo A, Muraguchi A, Takeda M, Tani K
Molecular Therapy 2020;28(1):129-141

Loss of TMEM 106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice

Feng T, Mai S, Roscoe J, Sheng R, Ullah M, Zhang J, Katz I, Yu H, Xiong W, Hu F
EMBO reports 2020;21(10)

Temporal activation of LRH‐1 and RAR‐γ in human pluripotent stem cells induces a functional naïve‐like state

Taei A, Kiani T, Taghizadeh Z, Moradi S, Samadian A, Mollamohammadi S, Sharifi‐Zarchi A, Guenther S, Akhlaghpour A, Asgari Abibeiglou B, Najar‐Asl M, Karamzadeh R, Khalooghi K, Braun T, Hassani S, Baharvand H
EMBO reports 2020;21(10)

Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

Li D, Shao R, Wang N, Zhou N, Du K, Shi J, Wang Y, Zhao Z, Ye X, Zhang X, Xu H
Autophagy 2020;17(4):872-887

TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium

Kim H, Lee G, Bhattarai K, Lee M, Back S, Kim H, Chae H
Autophagy 2020;17(3):761-778

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

Behr M, Bryk R, Mundhra S, Jiang X, Wood M, Pfau D, Weber E, Park S, Zhang L, Wilson C, Van der Westhuyzen R, Street L, Chibale K, Zimmerman M, Dartois V, Pastore N, Ballabio A, Hawryluk N, Canan S, Khetani V, Camardo J, Nathan C
PLOS Pathogens 2020;16(6):e1008567

Blood and lymphatic systems are segregated by the FLCN tumor suppressor

Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Li W, Mukouyama Y, Marston Linehan W, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, Baba M, Kubota Y
Nature Communications 2020;11(1)

TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress

Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302

N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

Chen Y, Navarrete M, Wang Y, McClintock N, Sakurai R, Wang F, Chen K, Chou T, Rehan V, Lee D, Diaz B
Scientific Reports 2020;10(1)

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, Charles P, Frau L, Hublitz P, Yu Z, Mohammed S, Ballabio A, Balabanov S, Mellor J, Simon A
Molecular Cell 2019;76(1):110-125.e9

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity

Horiguchi H, Kadomatsu T, Kurahashi R, Hara C, Miyata K, Baba M, Osumi H, Terada K, Araki K, Takai T, Kamba T, Linehan W, Moroishi T, Oike Y
Genes & Development 2019;33(23-24):1641-1656

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

El-Houjeiri L, Possik E, Vijayaraghavan T, Paquette M, Martina J, Kazan J, Ma E, Jones R, Blanchette P, Puertollano R, Pause A
Cell Reports 2019;26(13):3613-3628.e6

TFEB controls retromer expression in response to nutrient availability

Curnock R, Calcagni A, Ballabio A, Cullen P
Journal of Cell Biology 2019;218(12):3954-3966

Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis

Wang S, Ni H, Chao X, Wang H, Bridges B, Kumer S, Schmitt T, Mareninova O, Gukovskaya A, De Lisle R, Ballabio A, Pacher P, Ding W
Autophagy 2019;15(11):1954-1969

Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis

Mahanty S, Dakappa S, Shariff R, Patel S, Swamy M, Majumdar A, Setty S
Cell Death & Disease 2019;10(4)

Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole

Larson C, Sandoz K, Cockrell D, Heinzen R, Ballard J, Rikihisa Y, Carlyon J
mBio 2019;10(1)

Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency

Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille A, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins R, Moon R, Ware C, Paddison P, Ruohola-Baker H
Nature Communications 2019;10(1)

MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, Mosca R, Campos Y, Tillman H, Roussel M, Andrew Weesner J, Ellen Fremuth L, Qiu X, Han M, Grosveld G, d’Azzo A
Nature Communications 2019;10(1)

Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis

Li J, Wada S, Weaver L, Biswas C, Behrens E, Arany Z
JCI Insight 2019

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

Jeong E, Brady O, Martina J, Pirooznia M, Tunc I, Puertollano R
eLife 2018;7

Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation

Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, Suda T
Journal of Bone and Mineral Research 2018;33(10):1785-1798

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

Martina J, Puertollano R
Journal of Biological Chemistry 2018;293(32):12525-12534

Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice

Chao X, Wang S, Zhao K, Li Y, Williams J, Li T, Chavan H, Krishnamurthy P, He X, Li L, Ballabio A, Ni H, Ding W
Gastroenterology 2018;155(3):865-879.e12

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells

Pi H, Li M, Zou L, Yang M, Deng P, Fan T, Liu M, Tian L, Tu M, Xie J, Chen M, Li H, Xi Y, Zhang L, He M, Lu Y, Chen C, Zhang T, Wang Z, Yu Z, Gao F, Zhou Z
Autophagy 2018;15(4):565-582

Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia

Liu Y, Xue X, Zhang H, Che X, Luo J, Wang P, Xu J, Xing Z, Yuan L, Liu Y, Fu X, Su D, Sun S, Zhang H, Wu C, Yang J
Autophagy 2018;15(3):493-509

AAVvector-mediated in vivo reprogramming into pluripotency.

Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D
Nature communications 2018 Jul 9;9(1):2651

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Sergin I, Evans T, Zhang X, Bhattacharya S, Stokes C, Song E, Ali S, Dehestani B, Holloway K, Micevych P, Javaheri A, Crowley J, Ballabio A, Schilling J, Epelman S, Weihl C, Diwan A, Fan D, Zayed M, Razani B
Nature Communications 2017;8(1)

mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy

Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano A, Monfregola J, De Gennaro E, Nusco E, Azario I, Lanzara C, Serafini M, Levine B, Ballabio A, Settembre C
Journal of Clinical Investigation 2017;127(10):3717-3729

Lysosomal adaptation: How cells respond to lysosomotropic compounds

Komatsu M, Lu S, Sung T, Lin N, Abraham R, Jessen B
PLOS ONE 2017;12(3):e0173771

Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice

Yang D, Stavrides P, Kumar A, Jiang Y, Mohan P, Ohno M, Dobrenis K, Davidson C, Saito M, Pawlik M, Huo C, Walkley S, Nixon R
Human Molecular Genetics 2017

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H
Nature Communications 2016;7(1)

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

Wada S, Neinast M, Jang C, Ibrahim Y, Lee G, Babu A, Li J, Hoshino A, Rowe G, Rhee J, Martina J, Puertollano R, Blenis J, Morley M, Baur J, Seale P, Arany Z
Genes & Development 2016;30(22):2551-2564

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, Lim J, Zare H, Raben N, Ballabio A, Puertollano R
Autophagy 2016;12(8):1240-1258

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Bordi M, Berg M, Mohan P, Peterhoff C, Alldred M, Che S, Ginsberg S, Nixon R
Autophagy 2016;12(12):2467-2483

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

Martina J, Diab H, Lishu L, Jeong-A L, Patange S, Raben N, Puertollano R
Science Signaling 2014;7(309)

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P, Smith A
Cell 2014;158(6):1254-1269

Derivation of novel human ground state naive pluripotent stem cells

Gafni O, Weinberger L, Mansour A, Manor Y, Chomsky E, Ben-Yosef D, Kalma Y, Viukov S, Maza I, Zviran A, Rais Y, Shipony Z, Mukamel Z, Krupalnik V, Zerbib M, Geula S, Caspi I, Schneir D, Shwartz T, Gilad S, Amann-Zalcenstein D, Benjamin S, Amit I, Tanay A, Massarwa R, Novershtern N, Hanna J
Nature 2013;504(7479):282-286

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

Betschinger J, Nichols J, Dietmann S, Corrin P, Paddison P, Smith A
Cell 2013;153(2):335-347

Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization

Bryk M, Hong S, Oh H, Valera V, Baba M, Schmidt L, Linehan W
PLoS ONE 2010;5(12):e15793

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