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TFE3
Transcription factor binding to IGHM enhancer 3bHLHe33, TFEA
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-54909 |
3 references | Polyclonal |
WB
ICC
IHC
OA
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| Proteintech Group | 14480-1-AP |
17 references | Polyclonal |
WB
EL
IP
IHC
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| Novus Biologicals | NBP1-89976 |
5 references | Polyclonal |
WB
ICC
IHC
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| LSBio | LS-C800480 |
Polyclonal |
WB
EL
ICC
IHC
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| Affinity Biosciences | AF0363 |
Polyclonal |
WB
EL
ICC
IHC
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