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- Antigen structure
- References [29]
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- Product number
- 18970-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- NKCC2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NKCC2 antibody (Cat. #18970-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infection.
Functional and metabolomic analysis of urinary extracellular vesicles from juvenile mice with renal compensatory hypertrophy.
Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease.
Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair after Ischemia and Reperfusion Injury.
WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.
Generation and characterization of an inducible renal proximal tubule-specific CreERT2 mouse.
Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells.
Mechanism of interdigitation formation at apical boundary of MDCK cell.
Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors.
Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids.
Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids.
Gene expression profile and injury sites in mice treated with Shiga toxin 2 and lipopolysaccharide as a Shiga toxin-associated hemolytic uremic syndrome model.
Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice.
Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na(+)-K(+)-ATPase in Mouse Kidney Thick Ascending Limb Tubules.
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk.
Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells.
Hnf4a Is Required for the Development of Cdh6-Expressing Progenitors into Proximal Tubules in the Mouse Kidney.
Identification and characterization of two morphologically distinct stem cell subpopulations from human urine samples.
Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors.
Na(+)-K(+)-2Cl(-) cotransporter 2 located in the human and murine gastric mucosa is involved in secretagogue-induced gastric acid secretion and is downregulated in lipopolysaccharide-treated mice.
A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids.
β-catenin regulates the formation of multiple nephron segments in the mouse kidney.
Reduced Abd-B Hox function during kidney development results in lineage infidelity.
Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.
A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation.
Notch signaling promotes nephrogenesis by downregulating Six2.
Vanslambrouck JM, Neil JA, Rudraraju R, Mah S, Tan KS, Groenewegen E, Forbes TA, Karavendzas K, Elliott DA, Porrello ER, Subbarao K, Little MH
Journal of virology 2024 Mar 19;98(3):e0180223
Journal of virology 2024 Mar 19;98(3):e0180223
Functional and metabolomic analysis of urinary extracellular vesicles from juvenile mice with renal compensatory hypertrophy.
Aly R, Darwish S, Bala N, Ebrahim A, Shoemaker LR, McCray J, Garrett TJ, Alli AA
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167096
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167096
Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease.
Vishy CE, Thomas C, Vincent T, Crawford DK, Goddeeris MM, Freedman BS
Cell stem cell 2024 Apr 4;31(4):537-553.e5
Cell stem cell 2024 Apr 4;31(4):537-553.e5
Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair after Ischemia and Reperfusion Injury.
Moon D, Padanilam BJ, Park KM, Kim J
International journal of molecular sciences 2024 Apr 23;25(9)
International journal of molecular sciences 2024 Apr 23;25(9)
WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.
Hong X, Nie H, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W, Hou F, Zhang F
Theranostics 2023;13(4):1311-1324
Theranostics 2023;13(4):1311-1324
Generation and characterization of an inducible renal proximal tubule-specific CreERT2 mouse.
Liang S, Wang Y, Kang M, Deng J, Chen L, Hong X, Hou FF, Zhang F
Frontiers in cell and developmental biology 2023;11:1171637
Frontiers in cell and developmental biology 2023;11:1171637
Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells.
Vanslambrouck JM, Tan KS, Mah S, Little MH
Nature protocols 2023 Nov;18(11):3229-3252
Nature protocols 2023 Nov;18(11):3229-3252
Mechanism of interdigitation formation at apical boundary of MDCK cell.
Miyazaki S, Otani T, Sugihara K, Fujimori T, Furuse M, Miura T
iScience 2023 May 19;26(5):106594
iScience 2023 May 19;26(5):106594
Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors.
Nie H, Zhao Z, Zhou D, Li D, Wang Y, Ma Y, Liu X, Zuo W
Cell proliferation 2023 Apr;56(4):e13394
Cell proliferation 2023 Apr;56(4):e13394
Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids.
Vanslambrouck JM, Wilson SB, Tan KS, Groenewegen E, Rudraraju R, Neil J, Lawlor KT, Mah S, Scurr M, Howden SE, Subbarao K, Little MH
Nature communications 2022 Oct 8;13(1):5943
Nature communications 2022 Oct 8;13(1):5943
Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
Wang B, Wang Y, Wen Y, Zhang YL, Ni WJ, Tang TT, Cao JY, Yin Q, Jiang W, Yin D, Li ZL, Lv LL, Liu BC
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3300-3312
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3300-3312
Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids.
Vanslambrouck JM, Wilson SB, Tan KS, Groenewegen E, Rudraraju R, Neil J, Lawlor KT, Mah S, Scurr M, Howden SE, Subbarao K, Little MH
bioRxiv : the preprint server for biology 2022 May 27;
bioRxiv : the preprint server for biology 2022 May 27;
Gene expression profile and injury sites in mice treated with Shiga toxin 2 and lipopolysaccharide as a Shiga toxin-associated hemolytic uremic syndrome model.
Kume Y, Go H, Maeda R, Suyama K, Mori T, Kawasaki Y, Hashimoto K, Hosoya M
Physiological genomics 2022 May 1;54(5):153-165
Physiological genomics 2022 May 1;54(5):153-165
Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
Shao S, Li XD, Lu YY, Li SJ, Chen XH, Zhou HD, He S, Guo YT, Lu X, Gao PJ, Wang JG
Hypertension (Dallas, Tex. : 1979) 2021 Mar 3;77(3):868-881
Hypertension (Dallas, Tex. : 1979) 2021 Mar 3;77(3):868-881
Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice.
Luan Z, Wei Y, Huo X, Sun X, Zhang C, Ming W, Luo Z, Du C, Li Y, Xu H, Lu H, Zheng F, Guan Y, Zhang X
Biochimica et biophysica acta. Molecular basis of disease 2021 Mar 1;1867(3):165996
Biochimica et biophysica acta. Molecular basis of disease 2021 Mar 1;1867(3):165996
Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na(+)-K(+)-ATPase in Mouse Kidney Thick Ascending Limb Tubules.
Ritter JK, Ahmad A, Mummalaneni S, Daneva Z, Dempsey SK, Li N, Li PL, Lyall V
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):1-11
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):1-11
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk.
Howden SE, Wilson SB, Groenewegen E, Starks L, Forbes TA, Tan KS, Vanslambrouck JM, Holloway EM, Chen YH, Jain S, Spence JR, Little MH
Cell stem cell 2021 Apr 1;28(4):671-684.e6
Cell stem cell 2021 Apr 1;28(4):671-684.e6
Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells.
Love H, Evans R, Humes HD, Roy S, Zent R, Harris R, Wilson M, Fissell WH
Tissue engineering. Part A 2020 Oct;26(19-20):1091-1098
Tissue engineering. Part A 2020 Oct;26(19-20):1091-1098
Hnf4a Is Required for the Development of Cdh6-Expressing Progenitors into Proximal Tubules in the Mouse Kidney.
Marable SS, Chung E, Park JS
Journal of the American Society of Nephrology : JASN 2020 Nov;31(11):2543-2558
Journal of the American Society of Nephrology : JASN 2020 Nov;31(11):2543-2558
Identification and characterization of two morphologically distinct stem cell subpopulations from human urine samples.
Chen AJ, Pi JK, Hu JG, Huang YZ, Gao HW, Li SF, Li-Ling J, Xie HQ
Science China. Life sciences 2020 May;63(5):712-723
Science China. Life sciences 2020 May;63(5):712-723
Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors.
Fu Y, Yuan PP, Cao YG, Ke YY, Zhang Q, Hou Y, Zhang YL, Feng WS, Zheng XK
The Journal of pharmacy and pharmacology 2020 Dec;72(12):1956-1969
The Journal of pharmacy and pharmacology 2020 Dec;72(12):1956-1969
Na(+)-K(+)-2Cl(-) cotransporter 2 located in the human and murine gastric mucosa is involved in secretagogue-induced gastric acid secretion and is downregulated in lipopolysaccharide-treated mice.
Zheng LF, Ji T, Guo ZH, Wang T, Xiu XL, Liu XY, Li SC, Sun L, Xue H, Zhang Y, Zhu JX
European journal of pharmacology 2020 Aug 5;880:173162
European journal of pharmacology 2020 Aug 5;880:173162
A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids.
Vanslambrouck JM, Wilson SB, Tan KS, Soo JY, Scurr M, Spijker HS, Starks LT, Neilson A, Cui X, Jain S, Little MH, Howden SE
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1811-1823
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1811-1823
β-catenin regulates the formation of multiple nephron segments in the mouse kidney.
Deacon P, Concodora CW, Chung E, Park JS
Scientific reports 2019 Nov 4;9(1):15915
Scientific reports 2019 Nov 4;9(1):15915
Reduced Abd-B Hox function during kidney development results in lineage infidelity.
Magella B, Mahoney R, Adam M, Potter SS
Developmental biology 2018 Jun 15;438(2):84-93
Developmental biology 2018 Jun 15;438(2):84-93
Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
Marable SS, Chung E, Adam M, Potter SS, Park JS
JCI insight 2018 Jul 26;3(14)
JCI insight 2018 Jul 26;3(14)
EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.
Zhang L, Ettou S, Khalid M, Taglienti M, Jain D, Jung YL, Seager C, Liu Y, Ng KH, Park PJ, Kreidberg JA
Development (Cambridge, England) 2018 Jul 18;145(14)
Development (Cambridge, England) 2018 Jul 18;145(14)
A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation.
Basta JM, Robbins L, Denner DR, Kolar GR, Rauchman M
Development (Cambridge, England) 2017 Sep 1;144(17):3080-3094
Development (Cambridge, England) 2017 Sep 1;144(17):3080-3094
Notch signaling promotes nephrogenesis by downregulating Six2.
Chung E, Deacon P, Marable S, Shin J, Park JS
Development (Cambridge, England) 2016 Nov 1;143(21):3907-3913
Development (Cambridge, England) 2016 Nov 1;143(21):3907-3913
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