SLC12A1

gene product
NKCC2
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven. [provided by RefSeq, May 2010]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
233 antibodies from 32 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
NovoPro Bioscience Inc.
3 antibodies
antibodies-online
72 antibodies
Novus Biologicals
5 antibodies
Atlas Antibodies
2 antibodies
GeneTex
2 antibodies
Boster Biological Technology
2 antibodies
LifeSpan BioSciences, Inc.
57 antibodies
OriGene
4 antibodies
NSJ Bioreagents
2 antibodies
Biorbyt
12 antibodies
Aviva Systems Biology
1 antibody
FabGennix
3 antibodies
Invitrogen Antibodies
3 antibodies
Proteintech Group
1 antibody
Cell Signaling Technology, Inc
2 antibodies
Bioworld Technology, Inc
1 antibody
ProSci
1 antibody
Everest Biotech
1 antibody
Creative Biolabs
10 antibodies
Acris Antibodies GmbH
3 antibodies
Abnova Corporation
2 antibodies
Abgent
3 antibodies
Creative Diagnostics
2 antibodies
Affinity Biosciences
1 antibody
St John's Laboratory
1 antibody
United States Biological
27 antibodies
Sigma-Aldrich
3 antibodies
MyBioSource
2 antibodies
EMD Millipore
2 antibodies
RabMAbs
1 antibody
GenWay
1 antibody
RayBiotech, Inc.
1 antibody