RA0002

antibody from Oursmab

Targeting: ACVR2B ActR-IIB

Immunocytochemistry

Flow cytometry

Functional assay

Antibody data

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Validation data

Product number: RA0002 - Provider product page
Provider: Oursmab
Product name: Bimagrumab (Biosimilar Reference Antibody) (ACVR2B)
Antibody type: Monoclonal
Description: Bimagrumab is a fully human monoclonal antibody (IgG1/¦Ë) designed to block the activin type II receptors (ActRII). It functions as a potent and selective antagonist that binds to ActRIIA and ActRIIB with high affinity, thereby inhibiting the binding of several negative regulators of muscle growth, including myostatin (GDF-8), activin A, and GDF-11. By blocking this signaling pathway, bimagrumab aims to promote skeletal muscle hypertrophy and increase muscle mass and strength. It has been investigated in clinical trials for conditions involving muscle wasting and weakness, such as sporadic inclusion body myositis (sIBM), sarcopenia, and obesity with mobility limitation. While it demonstrated significant increases in lean body mass, its development for sIBM was discontinued after Phase II/III trials did not meet the primary functional endpoint.
Reactivity: Human
Isotype: IgG
Vial size: 100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg
Concentration: Bottled at the concentration indicated on the vial.
Storage: Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

ACVR2B protein structure - RA0002 shown in red.