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ACVR2B
Activin A receptor type 2BActR-IIB
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| R&D Systems |  AF339 |
7 references | Polyclonal |
WB
IHC
BN
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| Novus Biologicals | AF339 |
7 references | Polyclonal |
WB
IHC
BN
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| antibodies-online | ABIN2841269 |
5 references | Polyclonal |
WB
IHC
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| Abnova Corporation | PAB2022 |
4 references | Polyclonal |
WB
IHC
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| LSBio | LS-C807674 |
Polyclonal |
WB
EL
IHC
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