11603-1-AP

antibody from Proteintech Group

Targeting: CCT5 KIAA0098

Provider product page for 11603-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11603-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11603-1-AP, RRID:AB_2073774
Product name: CCT5 antibody
Antibody type: Polyclonal
Description: KD/KO validated CCT5 antibody (Cat. #11603-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CCT5 protein structure - 11603-1-AP shown in red.

Submitted references CCT5 as a candidate biomarker in bladder cancer: functional validation and mechanistic clues.

Zhang X, Fu Y, Du Y, Xiong W, Wang J, Zhang H, Luo Y, Zhao Y, Shang P
American journal of cancer research 2026;16(1):51-69

The oncogenic role of NSUN2 in lung adenocarcinoma by stabilizing CCT5 mRNA via a YBX1-dependent m5C modification.

Li M, Du N, Tang P
Molecular and cellular biochemistry 2026 Jan;481(1):231-243

Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunction.

Chen R, Stockwell I, Pierce JC, Peak-Chew SY, Huang M, Newell K, Ghetti B, Cousin MA, Greger IH, Ryskeldi-Falcon B
bioRxiv : the preprint server for biology 2026 Jan 27;

Candidate Interaction Partners of Calpain-5 Suggest Clues to Its Involvement in Neovascular Inflammatory Vitreoretinopathy.

Gal J, Bondada V, Crasta R, Croall DE, Vary CP, Geddes JW
Cells 2026 Jan 13;15(2)

Unveiling the role of hexon-associated host proteins in fowl adenovirus serotype 4 replication.

Zhang X, Wang X, Zhao Y, Li S, Xu X
Frontiers in veterinary science 2025;12:1562872

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures.

Ding Y, Zuo Y, Zhang B, Fan Y, Xu G, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, Xiong M, Li J, Han Z, Sun S, Wang S, He F, Yang J, Qu J, Zhang W, Liu GH
Cell 2025 Oct 2;188(20):5763-5784.e26

Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine learning, and experimental validation.

Li J, Xu N, Hu L, Xu J, Huang Y, Wang D, Chen F, Wang Y, Jiang J, Hong Y, Ye H
Cancer immunology, immunotherapy : CII 2025 May 27;74(7):224

In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor.

Xing H, Rosenkranz RRE, Rodriguez-Aliaga P, Lee TT, Majtner T, Böhm S, Turoňová B, Frydman J, Beck M
Nature 2025 Jan;637(8047):983-990

Increased CCT5 expression is a potential unfavourable factor promoting the growth of nasopharyngeal carcinoma.

Wu S, Peng L
The Journal of international medical research 2024 Sep;52(9):3000605241271754

TRiC/CCT chaperonin is required for the folding and inhibitory effect of WDTC1 on adipogenesis.

Tang WS, Cen X, Yao SS, Yin ST, Weng L, Zhao TJ, Wang X
Frontiers in cell and developmental biology 2023;11:1225628

Novel biomarkers to predict treatment response and prognosis in locally advanced rectal cancer undergoing neoadjuvant chemoradiotherapy.

Guan B, Xu M, Zheng R, Guan G, Xu B
BMC cancer 2023 Nov 12;23(1):1099

Chaperonin-Containing TCP1 Subunit 5 Protects Against the Effect of Mer Receptor Tyrosine Kinase Knockdown in Retinal Pigment Epithelial Cells by Interacting With Filamentous Actin and Activating the LIM-Kinase 1/Cofilin Pathway.

Feng L, Li H, Du Y, Zhang T, Zhu Y, Li Z, Zhao L, Wang X, Wang G, Zhou L, Jiang Z, Liu Z, Ou Z, Wen Y, Zhuo Y
Frontiers in medicine 2022;9:861371

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.

Ma X, Lu C, Chen Y, Li S, Ma N, Tao X, Li Y, Wang J, Zhou M, Yan YB, Li P, Heydari K, Deng H, Zhang M, Yi C, Ge L
Cell 2022 Apr 14;185(8):1325-1345.e22

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.

Zhang YC, Bai YF, Yuan JF, Shen XL, Xu YL, Jian XX, Li S, Song ZQ, Hu HB, Li PY, Tu HQ, Han QY, Wang N, Li AL, Zhang XM, Wu M, Zhou T, Li HY
The Journal of cell biology 2021 Feb 1;220(2)

CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion.

Meng Y, Yang L, Wei X, Luo H, Hu Y, Tao X, He J, Zheng X, Xu Q, Luo K, Yu G, Luo Q
Biochemical and biophysical research communications 2021 Aug 27;567:222-229

Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.

Zhang X, Lin X, Qin C, Huang K, Sun X, Zhao L, Jin M
Frontiers in microbiology 2020;11:538355

DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, Köhler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K, UK10K, Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H
Nature genetics 2013 Sep;45(9):995-1003

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

Seo S, Baye LM, Schulz NP, Beck JS, Zhang Q, Slusarski DC, Sheffield VC
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1488-93

Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT.

Yamabe K, Maeda H, Kokeguchi S, Soga Y, Meguro M, Naruishi K, Asakawa S, Takashiba S
Molecular oral microbiology 2010 Apr;25(2):112-22

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11603-1-AP(CCT5 antibody) at dilution of 1:400
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using CCT5 antibody 11603-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 11603-1-AP(CCT5 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue