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Protein structure
CCT5
Chaperonin containing TCP1 subunit 5KIAA0098
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Top validated antibodies |
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| Novus Biologicals |  H00022948-M01 |
5 references | Monoclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN394351 |
5 references | Monoclonal |
WB
EL
ICC
IHC
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| Abnova Corporation | H00022948-M01 |
3 references | Monoclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX110167 |
Polyclonal |
WB
ICC
IP
IHC
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| Invitrogen Antibodies | 11603-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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