Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- AF1754 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse Integrin alpha 5/CD49e Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse Integrin alpha 5/CD49e in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) Integrin alpha 5 is observed, 15% cross-reactivity with rhIntegrin alpha 2 and rhIntegrin alpha M is observed, and 5% cross-reactivity with rhIntegrin alpha E is observed.
- Reactivity
- Mouse
- Host
- Sheep
- Conjugate
- Unconjugated
- Antigen sequence
P11688
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation.
Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.
Batra N, Riquelme MA, Burra S, Kar R, Gu S, Jiang JX
The Journal of biological chemistry 2014 Apr 11;289(15):10582-91
The Journal of biological chemistry 2014 Apr 11;289(15):10582-91
Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.
Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3359-64
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3359-64
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