14424-1-AP

antibody from Proteintech Group

Targeting: TAX1BP1 CALCOCO3, TXBP151

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

14424-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14424-1-AP, RRID:AB_2198921

Product name

TAX1BP1 antibody

Antibody type

Polyclonal

Description

TAX1BP1 antibody (Cat. #14424-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis.

Xu L, Bottermann M, Villavicencio PM, Warner J, Weldon SR, Xie Z, Filby A, Liu X, Ganley IG, Ringel AE, Nair U, Batista FD
The Journal of experimental medicine 2026 Mar 2;223(3)

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Targeting VCP with V8 suppresses glioblastoma development via formation of aggregates and disruption of mitophagy flux.

Cao X, Li Y, Guo B, Liu Y, Wang B, Wang H, Lu J, Wei L, Gao Y, Guo Y, Wu T
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 8;49(1):21

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TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and-independent mitophagy.

Levi-D'Ancona E, Walker EM, Zhu J, Deng Y, Sidarala V, Stendahl AM, Reck EC, Henry-Kanarek BA, Lietzke AC, Pasmooij MB, Hubers DL, Basrur V, Ghosh S, Stiles L, Nesvizhskii AI, Shirihai OS, Soleimanpour SA
bioRxiv : the preprint server for biology 2025 Sep 5;

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Pseudorabies virus induces ferroptosis by disrupting iron homeostasis through activation of TfR1 and ferritinophagy.

Ma Z, Guo L, Ji R, Sun Z, Wang J, Yan Y, Liu K, Zhang H, Wang X, Wu C, Lian L, Cao W, Bai J, Jiang P, Liu X
Journal of virology 2025 Sep 23;99(9):e0097425

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The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency.

Yang K, Torres-Ramirez G, Dobbs N, Han J, Asahina M, Fujinawa R, Song K, Liu Y, Lin W, Oviedo A, Chen C, Zhu L, Mueller WF, Lee K, Suzuki T, Yan N
The Journal of experimental medicine 2025 Oct 6;222(10)

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TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy.

Levi-D'Ancona E, Walker EM, Zhu J, Deng Y, Sidarala V, Stendahl AM, Reck EC, Henry-Kanarek BA, Lietzke AC, Chai B, Pasmooij MB, Hubers DL, Basrur V, Ghosh S, Stiles L, Nesvizhskii AI, Shirihai OS, Soleimanpour SA
Science advances 2025 Oct 10;11(41):eadw4153

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Spinal Cord Phosphoproteome of SCA2 Mouse Model Reveals Alteration of ATXN2-N-Term PRM-SH3-Actin Interactome and of Autophagy.

Almaguer-Mederos LE, Kandi AR, Sen NE, Canet-Pons J, Berger LM, Stokes MP, Abell K, Key J, Gispert S, Auburger G
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101072

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EPIC-1042 alleviates cerebral ischemic/reperfusion injury through TAX1BP1-induced mitophagy.

Ju J, Cheng C, Cui L, Hong B, Zhan Q, Wang Q, Cui X, Su D, Huang Y, Kang C
Free radical biology & medicine 2025 May;232:367-381

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The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease.

Shen H, Xie Y, Wang Y, Xie Y, Wang Y, Su Z, Zhao L, Yao S, Cao X, Liang J, Long J, Zhong R, Tang J, Wang S, Zhang L, Wang X, Stork B, Cui L, Wu W
Autophagy 2025 May;21(5):1096-1115

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IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.

Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105

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Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates.

White J, Choi YB, Zhang J, Vo MT, He C, Shaikh K, Harhaj EW
Autophagy 2025 Jan;21(1):160-177

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Activation of lysophagy by a TBK1-SCF(FBXO3)-TMEM192-TAX1BP1 axis in response to lysosomal damage.

Park NY, Jo DS, Yang JY, Bae JE, Kim JB, Kim YH, Kim SH, Kim P, Lee DS, Yoshimori T, Jo EK, Yeom E, Cho DH
Nature communications 2025 Jan 28;16(1):1109

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Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.

Chen H, Zhu M, Zhao Z, Jiang Y, Wang H, Liu Y, Chen Y, Li H, Xun C, Hui H
Pharmacological research 2025 Dec;222:108050

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Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study.

Lee MS, Son SJ, Kim J, Go S, Hong CH, Roh HW, Chang J
Biomedicines 2025 Dec 23;14(1)

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Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.

Sun HJ, Lu QB, Liu SJ, Fu X, Yu CL, Su JB, Meng XY, Guo X, Shao X, Li JH, Sun QY, Zhu XX, Shan JJ, Zhou W
Cell reports. Medicine 2025 Aug 19;6(8):102241

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PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.

Hou S, Zhang J, Jiang X, Yang Y, Shan B, Zhang M, Liu C, Yuan J, Xu D
Molecular cell 2024 Mar 7;84(5):938-954.e8

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TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance.

Zhu YF, Yu RH, Zhou S, Tang PP, Zhang R, Wu YX, Xu R, Wei JM, Wang YY, Zhang JL, Li MK, Shi XJ, Zhang YW, Liu GZ, Thorne RF, Zhang XD, Wu M, Chen S
Zoological research 2024 Jul 18;45(4):937-950

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Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway.

Tao J, Xue C, Cao M, Ye J, Sun Y, Chen H, Guan Y, Zhang W, Zhang W, Yao Y
Breast cancer research : BCR 2024 Jan 2;26(1):1

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Alleviation of monocyte exhaustion by BCG derivative mycolic acid.

Wu Y, Caldwell B, Wang J, Zhang Y, Li L
iScience 2024 Feb 16;27(2):108978

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TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity.

Wang J, Wu Y, Lin R, Zhang Y, Li L
Frontiers in immunology 2023;14:1297329

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Copper-dependent autophagic degradation of GPX4 drives ferroptosis.

Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky DJ, Kroemer G, Chen X, Tang D, Liu J
Autophagy 2023 Jul;19(7):1982-1996

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Profiling of purified autophagic vesicle degradome in the maturing and aging brain.

Kallergi E, Siva Sankar D, Matera A, Kolaxi A, Paolicelli RC, Dengjel J, Nikoletopoulou V
Neuron 2023 Aug 2;111(15):2329-2347.e7

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PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.

Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, Weng P, Zheng L, Dong X, Hu S, Wang B, Qin X, Jiang X, Chen C, Zhang J, Zou Z
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The long noncoding RNA LTCONS5539 up-regulates the TRAF6-mediated immune responses in miiuy croaker (Miichthys miiuy).

Pan J, Zheng W, Sun Y, Xu T
Fish & shellfish immunology 2022 Jul;126:263-270

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A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.

Deng Q, Yang S, Sun L, Huang K, Dong K, Zhu Y, Cao Y, Li Y, Wu S, Huang R
Redox biology 2022 Feb;49:102217

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Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation.

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International immunopharmacology 2022 Dec;113(Pt A):109330

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Autophagy 2022 Apr;18(4):841-859

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FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

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TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.

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Zhong Z, Qian Z, Zhang X, Chen F, Ni S, Kang Z, Zhang F, Li D, Yu B
Frontiers in pharmacology 2019;10:1530

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Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.

Zachari M, Gudmundsson SR, Li Z, Manifava M, Cugliandolo F, Shah R, Smith M, Stronge J, Karanasios E, Piunti C, Kishi-Itakura C, Vihinen H, Jokitalo E, Guan JL, Buss F, Smith AM, Walker SA, Eskelinen EL, Ktistakis NT
Developmental cell 2019 Sep 9;50(5):627-643.e5

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A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy.

Yang C, Zang W, Tang Z, Ji Y, Xu R, Yang Y, Luo A, Hu B, Zhang Z, Liu Z, Zheng X
Cancer research 2018 Feb 15;78(4):1069-1082

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M
Cell 2016 Feb 25;164(5):896-910

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The TAX1BP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TAX1BP1. This antibody recognizes human, mouse antigen. The TAX1BP1 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

14424-1-AP.pdf

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