TAX1BP1

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Description

Tax1 binding protein 1

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Peptideatlas)

Chromosome

7:p15.2 (27739331 - 27844564)

Ensembl ID

ENSG00000106052  (ver. 99.38)

Orthologs

Mouse Tax1bp1: ENSMUSG00000004535

UniProt

Q86VP1

neXtProt

NX_Q86VP1

Human splice variants
Mouse splice variants