C10orf2

gene product
FLJ21832, IOSCA, PEO, PEO1, TWINKLE, TWINL
This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
153 antibodies from 22 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Proteintech Group
2 antibodies
GeneTex
2 antibodies
Bioworld Technology, Inc
1 antibody
NovoPro Bioscience Inc.
3 antibodies
antibodies-online
30 antibodies
Affinity Biosciences
1 antibody
LifeSpan BioSciences, Inc.
37 antibodies
OriGene
4 antibodies
Aviva Systems Biology
4 antibodies
Acris Antibodies GmbH
1 antibody
Novus Biologicals
4 antibodies
St John's Laboratory
2 antibodies
Biorbyt
5 antibodies
Invitrogen Antibodies
3 antibodies
ProSci
3 antibodies
Atlas Antibodies
1 antibody
United States Biological
38 antibodies
Creative Diagnostics
5 antibodies
Boster Biological Technology
1 antibody
MyBioSource
1 antibody
Sigma-Aldrich
3 antibodies
Abnova Corporation
2 antibodies