Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 66110-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- COXIV antibody
- Antibody type
- Monoclonal
- Description
- COXIV antibody (Cat. #66110-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2A7B2
- Vial size
- 150ul
Submitted references AI-driven identification of a selective dual function inhibitor blocking HK2 activity and HK2-VDAC1 interaction displaying enhanced anticancer efficacy under hypoxia.
CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistance.
FLVCR1 Deficiency Impairs Mitochondrial Homeostasis in Retinal Degeneration: Choline as a Potential Therapy.
GRP75 blocks hepatitis E virus infection by targeting HEV-ORF2 for degradation through chaperone-mediated autophagy and promoting IRF3 activation.
Integrated Profiling of DEHP-Induced Hippocampal Neurotoxicity in Adult Female Rats Based on Transcriptomic and Neurobiological Analyses.
Fiber type-specific expression of LACTB leverages a function in oxidative metabolism.
Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.
Carnosic acid attenuates diabetic retinopathy via the SIRT1 signaling pathway: neuroprotection and endothelial cell preservation.
Chaihushugan powder regulates the gut microbiota to alleviate mitochondrial oxidative stress in the gastric tissues of rats with functional dyspepsia.
Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer.
Mitochondrial transport of glutathione in diabetic retinopathy.
NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis.
Integrated multiomics reveals host-virus coadaptation in persistent foot-and-mouth disease virus infection.
Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway.
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
Compositionally unique mitochondria in filopodia support cellular migration.
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells.
Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis.
USP7 promotes PINK1/Parkin-dependent mitophagy to ameliorate cerebral ischemia-reperfusion injury by deubiquitinating and stabilizing SIRT1.
Twist2 knockdown alleviates renal ischemia-reperfusion injury by maintaining mitochondrial function and enhancing mitophagy through Bnip3.
Mitochondrial iron transporter ClMrs3/4 regulates iron homeostasis to modulate nitric oxide balance facilitating appressorial development in Curvularia lunata.
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration.
Heat shock protein 60 manipulates Foot-and-Mouth disease virus replication by regulating mitophagy.
The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes.
Apolipoprotein A-1 Accelerated Liver Regeneration Through Regulating Autophagy Via AMPK-ULK1 Pathway.
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis.
Ubiquitin-specific protease 1 facilitates hepatocellular carcinoma progression by modulating mitochondrial fission and metabolic reprogramming via cyclin-dependent kinase 5 stabilization.
Stearic acid alleviates aortic medial degeneration through maintaining mitochondrial dynamics homeostasis via inhibiting JNK/MAPK signaling.
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells.
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression.
Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway.
Compositionally unique mitochondria in filopodia support cellular migration.
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra.
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
The extracellular matrix integrates mitochondrial homeostasis.
Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus.
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Naringenin Alleviates Radiation-Induced Intestinal Injury by Inhibiting TRPV6 in Mice.
Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.
Chaihu Shugan Powder inhibits interstitial cells of cajal mitophagy through USP30 in the treatment of functional dyspepsia.
Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy.
Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue.
Mitophagy disorder mediates cardiac deterioration induced by severe hypoglycemia in diabetic mice.
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1.
Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis.
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.
Mitochondrial uncouplers impair human sperm motility without altering ATP content†.
Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.
Insulin induces insulin receptor degradation in the liver through EphB4.
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy.
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Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis.
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Twist2 knockdown alleviates renal ischemia-reperfusion injury by maintaining mitochondrial function and enhancing mitophagy through Bnip3.
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Mitochondrial iron transporter ClMrs3/4 regulates iron homeostasis to modulate nitric oxide balance facilitating appressorial development in Curvularia lunata.
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Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
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Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration.
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Heat shock protein 60 manipulates Foot-and-Mouth disease virus replication by regulating mitophagy.
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Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
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Frontiers in pharmacology 2024;15:1509482
Frontiers in pharmacology 2024;15:1509482
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis.
Li N, Zhao L, Geng X, Liu J, Zhang X, Hu Y, Qi J, Chen H, Qiu J, Zhang X, Jin S
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Theranostics 2024;14(11):4278-4296
Ubiquitin-specific protease 1 facilitates hepatocellular carcinoma progression by modulating mitochondrial fission and metabolic reprogramming via cyclin-dependent kinase 5 stabilization.
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Cell death and differentiation 2024 Sep;31(9):1202-1218
Stearic acid alleviates aortic medial degeneration through maintaining mitochondrial dynamics homeostasis via inhibiting JNK/MAPK signaling.
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iScience 2024 Sep 20;27(9):110594
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells.
Zhang Z, Yang D, Yan X, Qiu Q, Guo J, Qiu L
Cellular & molecular biology letters 2024 Nov 27;29(1):145
Cellular & molecular biology letters 2024 Nov 27;29(1):145
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
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Biochimica et biophysica acta. Bioenergetics 2024 Nov 1;1865(4):149492
O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression.
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ACS central science 2024 May 22;10(5):1065-1083
Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway.
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Free radical biology & medicine 2024 Jun;218:132-148
Free radical biology & medicine 2024 Jun;218:132-148
Compositionally unique mitochondria in filopodia support cellular migration.
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bioRxiv : the preprint server for biology 2024 Jun 21;
bioRxiv : the preprint server for biology 2024 Jun 21;
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
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Nature communications 2024 Jan 2;15(1):168
Nature communications 2024 Jan 2;15(1):168
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra.
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Neurobiology of aging 2024 Feb;134:43-56
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
Zhou Z, Xu L, Lv Y, Li L, Yuan H, Hu F
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
The extracellular matrix integrates mitochondrial homeostasis.
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Cell 2024 Aug 8;187(16):4289-4304.e26
Cell 2024 Aug 8;187(16):4289-4304.e26
Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus.
Wu Q, Yu S, Zang S, Peng K, Wang Z
Heliyon 2024 Aug 30;10(16):e36131
Heliyon 2024 Aug 30;10(16):e36131
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
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Redox biology 2024 Apr;70:103062
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Molecular nutrition & food research 2024 Apr;68(8):e2300745
Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.
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Inflammation 2024 Apr;47(2):718-732
Chaihu Shugan Powder inhibits interstitial cells of cajal mitophagy through USP30 in the treatment of functional dyspepsia.
Wang X, Liu X, Wang Y, Yang K, Yeertai Y, Jia Q, Li L, Jiang K, Du G, Ling J
Journal of ethnopharmacology 2024 Apr 6;323:117695
Journal of ethnopharmacology 2024 Apr 6;323:117695
Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy.
Chu L, Zhuo J, Huang H, Chen W, Zhong W, Zhang J, Meng X, Zou F, Cai S, Zou M, Dong H
European journal of pharmacology 2024 Apr 15;969:176459
European journal of pharmacology 2024 Apr 15;969:176459
Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue.
Wu Y, Zhou S, Pi D, Dong Y, Wang W, Ye H, Yi Z, Chen Y, Lin L, Ouyang M
Journal of oncology 2023;2023:5486017
Journal of oncology 2023;2023:5486017
Mitophagy disorder mediates cardiac deterioration induced by severe hypoglycemia in diabetic mice.
Huang C, Huang L, Huang Q, Lin L, Wang L, Wu Y, Wu K, Gao R, Liu X, Liu X, Qi L, Liu L
Molecular and cellular endocrinology 2023 Sep 15;575:111994
Molecular and cellular endocrinology 2023 Sep 15;575:111994
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
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bioRxiv : the preprint server for biology 2023 May 22;
bioRxiv : the preprint server for biology 2023 May 22;
Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1.
Han L, Zhang C, Wang D, Zhang J, Tang Q, Li MJ, Sack MN, Wang L, Zhu L
Oncogene 2023 Mar;42(13):1024-1037
Oncogene 2023 Mar;42(13):1024-1037
Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis.
Yazicioglu YF, Marin E, Sandhu C, Galiani S, Raza IGA, Ali M, Kronsteiner B, Compeer EB, Attar M, Dunachie SJ, Dustin ML, Clarke AJ
Nature immunology 2023 Jun;24(6):991-1006
Nature immunology 2023 Jun;24(6):991-1006
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.
Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y
Journal of translational medicine 2023 Jan 13;21(1):24
Journal of translational medicine 2023 Jan 13;21(1):24
Mitochondrial uncouplers impair human sperm motility without altering ATP content†.
Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, Lishko PV
Biology of reproduction 2023 Aug 10;109(2):192-203
Biology of reproduction 2023 Aug 10;109(2):192-203
Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.
Wang X, Yu S, Jian Y, Pan H, Guo J, Wu J, Guo W
Frontiers in cardiovascular medicine 2022;9:1023982
Frontiers in cardiovascular medicine 2022;9:1023982
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.
Zhang H, Yan M, Liu T, Wei P, Chai N, Li L, Wang J, Yu X, Lin Y, Qiu B, Zhao Y
Frontiers in cell and developmental biology 2022;10:840389
Frontiers in cell and developmental biology 2022;10:840389
Insulin induces insulin receptor degradation in the liver through EphB4.
Liu X, Wang K, Hou S, Jiang Q, Ma C, Zhao Q, Kong L, Chen J, Wang Z, Zhang H, Yuan T, Li Y, Huan Y, Shen Z, Hu Z, Huang Z, Cui B, Li P
Nature metabolism 2022 Sep;4(9):1202-1213
Nature metabolism 2022 Sep;4(9):1202-1213
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Nucleic acids research 2022 Sep 9;50(16):9368-9381
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
Wang ZC, Niu KM, Wu YJ, Du KR, Qi LW, Zhou YB, Sun HJ
Cell death & disease 2022 Sep 26;13(9):824
Cell death & disease 2022 Sep 26;13(9):824
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Li Q, Chu Y, Li S, Yu L, Deng H, Liao C, Liao X, Yang C, Qi M, Cheng J, Chen G, Huang L
Cell death & disease 2022 Oct 26;13(10):899
Cell death & disease 2022 Oct 26;13(10):899
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Zhong Y, Sun D, Yao Y, Liu Q, Guo T, Wang X, Peng X
Chemico-biological interactions 2022 Mar 1;355:109850
Chemico-biological interactions 2022 Mar 1;355:109850
Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy.
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Oncotarget 2017 Sep 29;8(44):76340-76356
Oncotarget 2017 Sep 29;8(44):76340-76356
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 66110-1-Ig(COXIV antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The COXIV antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human COXIV. This antibody recognizes human antigen. The COXIV antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 66110-1-Ig(COXIV antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 66110-1-Ig(COXIV antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue