66110-1-Ig

antibody from Proteintech Group

Targeting: COX4I1 COX4, COX4-1

Provider product page for 66110-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [34]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

Submit

Product number: 66110-1-Ig - Provider product page
Provider: Proteintech Group
Product name: COXIV antibody
Antibody type: Monoclonal
Description: COXIV antibody (Cat. #66110-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2A7B2
Vial size: 150ul

COX4I1 protein structure - 66110-1-Ig shown in red.

Submitted references Apolipoprotein A-1 Accelerated Liver Regeneration Through Regulating Autophagy Via AMPK-ULK1 Pathway.

Wang ZY, Chen RX, Wang JF, Liu SC, Xu X, Zhou T, Chen YAL, Zhang YD, Li XC, Li CX
Cellular and molecular gastroenterology and hepatology 2024;17(4):539-551

Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway.

Long Y, Ang Y, Chen W, Wang Y, Shi M, Hu F, Zhou Q, Shi Y, Ge B, Peng Y, Yu W, Bao H, Li Q, Duan M, Gao J
Free radical biology & medicine 2024 Jun;218:132-148

Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra.

Woulfe J, Munoz DG, Gray DA, Jinnah HA, Ivanova A
Neurobiology of aging 2024 Feb;134:43-56

VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.

Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062

Naringenin Alleviates Radiation-Induced Intestinal Injury by Inhibiting TRPV6 in Mice.

Ling Z, Wang Z, Chen L, Mao J, Ma D, Han X, Tian L, Zhu Q, Lu G, Yan X, Ding Y, Xiao W, Chen Y, Peng A, Yin X
Molecular nutrition & food research 2024 Apr;68(8):e2300745

Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.

Ji H, Zhao Y, Ma X, Wu L, Guo F, Huang F, Song Y, Wang J, Qin G
Inflammation 2024 Apr;47(2):718-732

Chaihu Shugan Powder inhibits interstitial cells of cajal mitophagy through USP30 in the treatment of functional dyspepsia.

Wang X, Liu X, Wang Y, Yang K, Yeertai Y, Jia Q, Li L, Jiang K, Du G, Ling J
Journal of ethnopharmacology 2024 Apr 6;323:117695

Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy.

Chu L, Zhuo J, Huang H, Chen W, Zhong W, Zhang J, Meng X, Zou F, Cai S, Zou M, Dong H
European journal of pharmacology 2024 Apr 15;969:176459

Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue.

Wu Y, Zhou S, Pi D, Dong Y, Wang W, Ye H, Yi Z, Chen Y, Lin L, Ouyang M
Journal of oncology 2023;2023:5486017

Mitophagy disorder mediates cardiac deterioration induced by severe hypoglycemia in diabetic mice.

Huang C, Huang L, Huang Q, Lin L, Wang L, Wu Y, Wu K, Gao R, Liu X, Liu X, Qi L, Liu L
Molecular and cellular endocrinology 2023 Sep 15;575:111994

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.

Wu J, Subbaiah KCV, Hedaya O, Chen S, Munger J, Tang WHW, Yan C, Yao P
bioRxiv : the preprint server for biology 2023 May 22;

Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1.

Han L, Zhang C, Wang D, Zhang J, Tang Q, Li MJ, Sack MN, Wang L, Zhu L
Oncogene 2023 Mar;42(13):1024-1037

Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.

Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y
Journal of translational medicine 2023 Jan 13;21(1):24

Mitochondrial uncouplers impair human sperm motility without altering ATP content†.

Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, Lishko PV
Biology of reproduction 2023 Aug 10;109(2):192-203

Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.

Wang X, Yu S, Jian Y, Pan H, Guo J, Wu J, Guo W
Frontiers in cardiovascular medicine 2022;9:1023982

Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.

Zhang H, Yan M, Liu T, Wei P, Chai N, Li L, Wang J, Yu X, Lin Y, Qiu B, Zhao Y
Frontiers in cell and developmental biology 2022;10:840389

Insulin induces insulin receptor degradation in the liver through EphB4.

Liu X, Wang K, Hou S, Jiang Q, Ma C, Zhao Q, Kong L, Chen J, Wang Z, Zhang H, Yuan T, Li Y, Huan Y, Shen Z, Hu Z, Huang Z, Cui B, Li P
Nature metabolism 2022 Sep;4(9):1202-1213

Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.

Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381

A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.

Wang ZC, Niu KM, Wu YJ, Du KR, Qi LW, Zhou YB, Sun HJ
Cell death & disease 2022 Sep 26;13(9):824

The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.

Li Q, Chu Y, Li S, Yu L, Deng H, Liao C, Liao X, Yang C, Qi M, Cheng J, Chen G, Huang L
Cell death & disease 2022 Oct 26;13(10):899

Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.

Zhong Y, Sun D, Yao Y, Liu Q, Guo T, Wang X, Peng X
Chemico-biological interactions 2022 Mar 1;355:109850

Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy.

Jin J, Yuan P, Yu W, Lin J, Xu A, Xu X, Lou J, Yu T, Qian C, Liu B, Song J, Li L, Piao Y, Xie T, Shen Y, Tao H, Tang J
ACS nano 2022 Jul 26;16(7):10327-10340

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery.

Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C
Molecular cell 2022 Jan 20;82(2):435-446.e7

Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner.

Tanaka E, Mitani T, Nakashima M, Yonemoto E, Fujii H, Ashida H
The Journal of nutritional biochemistry 2022 Feb;100:108898

The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.

Xiao W, Su J, Gao X, Yang H, Weng R, Ni W, Gu Y
Microbiome 2022 Apr 17;10(1):62

Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.

Xu L, Xu C, Liu X, Li X, Li T, Yu X, Xue M, Yang J, Kosmas CE, Moris D, Sanchis-Gomar F, Yoshida N, Berger NA, Aronow WS, Sun B, Chen L
Frontiers in physiology 2021;12:745058

Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.

Wang Q, Guan Z, Qi L, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P
Science (New York, N.Y.) 2021 Sep 17;373(6561):1377-1381

Jianpi Qushi Heluo Formula alleviates renal damages in Passive Hemann nephritis in rats by upregulating Parkin-mediated mitochondrial autophagy.

Wang XH, Lang R, Zeng Q, Liang Y, Chen N, Ma ZZ, Yu RH
Scientific reports 2021 Sep 15;11(1):18338

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.

Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
eLife 2021 May 26;10

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.

Wang X, Gong Q, Song C, Fang J, Yang Y, Liang X, Huang X, Liu J
Toxicology and applied pharmacology 2021 May 1;418:115484

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.

Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C
Nature communications 2020 Oct 1;11(1):4913

Hypoxia induces tumor cell growth and angiogenesis in non-small cell lung carcinoma via the Akt-PDK1-HIF1α-YKL-40 pathway.

Miao Y, Wang W, Dong Y, Hu J, Wei K, Yang S, Lai X, Tang H
Translational cancer research 2020 Apr;9(4):2904-2918

Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.

Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A
Nature cell biology 2019 Nov;21(11):1346-1356

Prohibitin, relocated to the front ends, can control the migration directionality of colorectal cancer cells.

Ma LL, Shen L, Tong GH, Tang N, Luo Y, Guo LL, Hu CT, Huang YX, Huang G, Jing FY, Liu C, Li ZY, Zhou N, Yan QW, Lei Y, Zhu SJ, Cheng ZQ, Cao GW, Deng YJ, Ding YQ
Oncotarget 2017 Sep 29;8(44):76340-76356

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 66110-1-Ig(COXIV antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The COXIV antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human COXIV. This antibody recognizes human antigen. The COXIV antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 66110-1-Ig.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 66110-1-Ig(COXIV antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 66110-1-Ig(COXIV antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue