Tissue expression
Cell line expression
Protein structure
COX4I1
Cytochrome c oxidase subunit 4I1COX4, COX4-1
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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Proteintech Group | 11242-1-AP | 399 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
GeneTex | GTX101499 | 3 references | Polyclonal |
WB
ICC
IP
IHC |
|
Invitrogen Antibodies | MA5-15078 | 7 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA |
|
St John's Laboratory | STJ99044 | Monoclonal |
WB
ICC
IP
IHC
FC
ChIP
OA
|
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Cell Signaling Technology, Inc | 4850 | 4 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
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