Tissue expression
Cell line expression
Protein structure
COX4I1
Cytochrome c oxidase subunit 4I1COX4, COX4-1
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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Proteintech Group | ![]() |
399 references | Polyclonal |
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GeneTex | ![]() |
3 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
7 references | Monoclonal |
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St John's Laboratory | ![]() |
Monoclonal |
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Cell Signaling Technology, Inc | ![]() |
4 references | Monoclonal |
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