MA1-35383

antibody from Invitrogen Antibodies

Targeting: GNRHR GRHR, LHRHR

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

MA1-35383

Provider

Invitrogen Antibodies

Product name

GnRHR Monoclonal Antibody (A9E4)

Antibody type

Monoclonal

Antigen

Synthetic peptide

Description

A9E4 reacts with GnRH receptors in the anterior pituitary. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinising hormone (LH) as well as follicle-stimulating hormone (FSH). The receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular, and intracellular loops, characteristic of G-protein coupled receptors. Some cancers like ovarian and breast cancers sometimes carry GnRH receptors

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

A9E4

Vial size

100 µg

Concentration

0.1 mg/mL

Storage

4° C

References

Submitted references

Gonadotropin-releasing hormone analogues reduce the proliferation of endometrial stromal cells but not endometriotic cells.

Taniguchi F, Higaki H, Azuma Y, Deura I, Iwabe T, Harada T, Terakawa N
Gynecologic and obstetric investigation 2013;75(1):9-15

---

Gonadotrophin-releasing hormone antagonist induces apoptosis in human decidual stromal cells: effect on GADD45α and MAPK signaling.

Wu HM, Wang HS, Soong YK, Huang HY, Chen CK, Lee CL, Leung PC
Human reproduction (Oxford, England) 2012 Mar;27(3):795-804

---

Type I gonadotropin-releasing hormone receptor mediates the antiproliferative effects of GnRH-II on prostate cancer cells.

Montagnani Marelli M, Moretti RM, Mai S, Januszkiewicz-Caulier J, Motta M, Limonta P
The Journal of clinical endocrinology and metabolism 2009 May;94(5):1761-7

---

Gonadotropin-releasing hormone type II induces apoptosis of human endometrial cancer cells by activating GADD45alpha.

Wu HM, Cheng JC, Wang HS, Huang HY, MacCalman CD, Leung PC
Cancer research 2009 May 15;69(10):4202-8