GNRHR

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

Gonadotropin releasing hormone receptor

Tissue specificity

Group enriched (brain, pituitary gland)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

4 (67737118 - 67754388)

Ensembl ID

ENSG00000109163  (ver. 103.38)

Orthologs

Mouse Gnrhr: ENSMUSG00000029255

UniProt

P30968

neXtProt

NX_P30968

Human splice variants
Mouse splice variants

Protein structure