Antibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Other assay [1]
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- Product number
- PA5-33597 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- GnRHR Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Percent identity with other species by BLAST analysis: Human, Gibbon (100%) Gorilla, Monkey, Dog, Elephant, Panda (95%) Marmoset, Bovine, Horse, Pig (90%).
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 50 µg
- Concentration
- 1 mg/mL
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Submitted references Natural autoantibodies to the gonadotropin-releasing hormone receptor in polycystic ovarian syndrome.
Sattler LM, Schniewind HA, Minich WB, Haudum CW, Niklowitz P, Münzker J, Kovács GL, Reinehr T, Obermayer-Pietsch B, Schomburg L
PloS one 2021;16(4):e0249639
PloS one 2021;16(4):e0249639
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Fig 2 Prevalence of GnRH-R-aAb in serum samples of controls and PCOS patients. A) The full set of samples (n = 1051) was analyzed for GnRH-R-aAb concentrations by measuring GnRH-R-Luc activity in the immunoprecipitates. Binding indices (BI) were calculated based on the lower half of all samples. The mean value plus three standard deviations (mean+3SD) was used as criterion for outliers, indicating positive presence of GnRH-R-aAb. Three samples were strongly positive, and 12 samples were slightly above the threshold (dashed line). B) The signals for GnRH-R-aAb were not normally distributed in the cohorts of samples analyzed. The prevalence of highly positive samples is similar in the cohorts of PCOS patients and control subjects (2 out of 651, i.e., 0.31%, vs. 1 out of 400, i.e., 0.25%).