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- Antibody Data
- Antigen structure
- References [27]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14955-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14955-1-AP, RRID:AB_2158292
- Product name
- OAS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OAS1 antibody (Cat. #14955-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas.
Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression.
A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.
Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family.
Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections.
Resurrection of 2'-5'-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication.
Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family.
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.
Interaction network of African swine fever virus structural protein p30 with host proteins.
Identification and validation of key biomarkers for the early diagnosis of diabetic kidney disease.
OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity.
Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.
A prenylated dsRNA sensor protects against severe COVID-19.
Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis.
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection.
Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
The CRISPR-Cas13a Gene-Editing System Induces Collateral Cleavage of RNA in Glioma Cells.
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.
Nakashoji A, Haratake N, Bhattacharya A, Mao W, Xu K, Wang K, Daimon T, Ozawa H, Shigeta K, Fushimi A, Yamashita N, Morimoto Y, Shimokawa M, Saito S, Egloff AM, Uppaluri R, Long MD, Kufe D
Cancer research communications 2024 May 14;4(5):1268-1281
Cancer research communications 2024 May 14;4(5):1268-1281
Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
Nature cell biology 2024 Mar;26(3):421-437
Nature cell biology 2024 Mar;26(3):421-437
Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression.
Zhou Y, Xiao Y, Liu H, Chen Q, Zhu L, Zeng L, Liu X, Pan Y, Zhang J, Fu J, Shao C
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C60-C73
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C60-C73
A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.
Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Metzger B, Bolus V, Kopper T, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW
bioRxiv : the preprint server for biology 2024 Apr 12;
bioRxiv : the preprint server for biology 2024 Apr 12;
Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family.
Torices S, Teglas T, Naranjo O, Fattakhov N, Frydlova K, Cabrera R, Osborne OM, Sun E, Kluttz A, Toborek M
Molecular neurobiology 2023 Sep;60(9):4966-4982
Molecular neurobiology 2023 Sep;60(9):4966-4982
Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections.
Salazar S, Luong KTY, Nua T, Koyuncu OO
Pathogens (Basel, Switzerland) 2023 Sep 7;12(9)
Pathogens (Basel, Switzerland) 2023 Sep 7;12(9)
Resurrection of 2'-5'-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication.
Lytras S, Wickenhagen A, Sugrue E, Stewart DG, Swingler S, Sims A, Jackson Ireland H, Davies EL, Ludlam EM, Li Z, Hughes J, Wilson SJ
PLoS biology 2023 Nov;21(11):e3002398
PLoS biology 2023 Nov;21(11):e3002398
Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family.
Torices S, Teglas T, Naranjo O, Fattakhov N, Frydlova K, Cabrera R, Osborne OM, Sun E, Kluttz A, Toborek M
Research square 2023 Jan 30;
Research square 2023 Jan 30;
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
Zeng Y, Chen HQ, Zhang Z, Fan J, Li JZ, Zhou SM, Wang N, Yan SP, Cao J, Liu JY, Zhou ZY, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.
Ke M
Oxidative medicine and cellular longevity 2022;2022:3124122
Oxidative medicine and cellular longevity 2022;2022:3124122
Interaction network of African swine fever virus structural protein p30 with host proteins.
Chen X, Chen X, Liang Y, Xu S, Weng Z, Gao Q, Huang Z, Zhang G, Gong L
Frontiers in microbiology 2022;13:971888
Frontiers in microbiology 2022;13:971888
Identification and validation of key biomarkers for the early diagnosis of diabetic kidney disease.
Yu W, Wang T, Wu F, Zhang Y, Shang J, Zhao Z
Frontiers in pharmacology 2022;13:931282
Frontiers in pharmacology 2022;13:931282
OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
Huang YZ, Zheng YX, Zhou Y, Xu F, Cui YZ, Chen XY, Wang ZY, Yan BX, Zheng M, Man XY
The Journal of investigative dermatology 2022 Oct;142(10):2635-2645.e9
The Journal of investigative dermatology 2022 Oct;142(10):2635-2645.e9
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
Shahraki AH, Tian R, Zhang C, Fregien NL, Bejarano P, Mirsaeidi M
Lung 2022 Aug;200(4):463-472
Lung 2022 Aug;200(4):463-472
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Zhao X, Di Q, Yu J, Quan J, Xiao Y, Zhu H, Li H, Ling J, Chen W
Autophagy 2022 Apr;18(4):891-908
Autophagy 2022 Apr;18(4):891-908
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity.
Cai R, Zhang X, Wang H, Cui T, Halmos G, Sha W, He J, Popovics P, Vidaurre I, Zhang C, Mirsaeidi M, Schally AV
Peptides 2022 Apr;150:170716
Peptides 2022 Apr;150:170716
Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.
Mariottoni P, Jiang SW, Prestwood CA, Jain V, Suwanpradid J, Whitley MJ, Coates M, Brown DA, Erdmann D, Corcoran DL, Gregory SG, Jaleel T, Zhang JY, Harris-Tryon TA, MacLeod AS
Frontiers in medicine 2021;8:665873
Frontiers in medicine 2021;8:665873
A prenylated dsRNA sensor protects against severe COVID-19.
Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhão Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G, ISARIC4C Investigators, Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ
Science (New York, N.Y.) 2021 Oct 29;374(6567):eabj3624
Science (New York, N.Y.) 2021 Oct 29;374(6567):eabj3624
Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis.
Che L, Yang H, Wang D, Liu S
Acta biochimica Polonica 2021 Nov 3;68(4):757-764
Acta biochimica Polonica 2021 Nov 3;68(4):757-764
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Li J, Qin X, Shi J, Wang X, Li T, Xu M, Chen X, Zhao Y, Han J, Piao Y, Zhang W, Qu P, Wang L, Xiang R, Shi Y
eLife 2021 Jun 11;10
eLife 2021 Jun 11;10
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Meng X, Chen Y, Macip S, Leppard K
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection.
Wang X, Chen QZ, Zan YX, Wang MR, Yan J, Guo WW, Li KJ, Liu YY, Luo F, Feng Y, Hou W, Xiong HR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13809-13825
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13809-13825
Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.
Fu Y, Fang Y, Lin Z, Yang L, Zheng L, Hu H, Yu T, Huang B, Chen S, Wang H, Xu S, Bao W, Chen Q, Sun L
iScience 2020 Apr 24;23(4):101026
iScience 2020 Apr 24;23(4):101026
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
Wang H, Yuan M, Wang S, Zhang L, Zhang R, Zou X, Wang X, Chen D, Wu Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
The CRISPR-Cas13a Gene-Editing System Induces Collateral Cleavage of RNA in Glioma Cells.
Wang Q, Liu X, Zhou J, Yang C, Wang G, Tan Y, Wu Y, Zhang S, Yi K, Kang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2019 Oct 16;6(20):1901299
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2019 Oct 16;6(20):1901299
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
Wang H, Xin X, Wang M, Han L, Li J, Hao Y, Zheng C, Shen C
Archives of virology 2018 Jun;163(6):1429-1438
Archives of virology 2018 Jun;163(6):1429-1438
STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.
Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA
Molecular cancer research : MCR 2016 May;14(5):482-92
Molecular cancer research : MCR 2016 May;14(5):482-92
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14955-1-AP(OAS1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 14955-1-AP(OAS1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OAS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OAS1. This antibody recognizes human,mouse,rat antigen. The OAS1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
