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- References [17]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 14330-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14330-1-AP, RRID:AB_2273600
- Product name
- ADAR1 antibody
- Antibody type
- Polyclonal
- Description
- ADAR1 antibody (Cat. #14330-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.
The involvement of ADAR1 in chronic unpredictable stress-induced cognitive impairment by targeting DARPP-32 with miR-874-3p in BALB/c mice.
ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis.
Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.
Depleting DDX1 sensitizes non-small cell lung cancer cells to chemotherapy by attenuating cancer stem cell traits.
Atractylodes lancea volatile oils target ADAR2-miR-181a-5p signaling to mesenchymal stem cell chondrogenic differentiation.
Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis.
The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.
Roles of miR-432 and circ_0000418 in mediating the anti-depressant action of ADAR1.
The involvement of ADAR1 in antidepressant action by regulating BDNF via miR-432.
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.
Decrease in ADAR1 expression by exposure to cigarette smoke enhances susceptibility to oxidative stress.
Increased AT(2)R expression is induced by AT(1)R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration.
LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer.
5-HT(2C)R antagonist/5-HT(2C)R inverse agonist recovered the increased isolation-induced aggressive behavior of BALB/c mice mediated by ADAR1 (p110) expression and Htr2c RNA editing.
Effects of social isolation and re-socialization on cognition and ADAR1 (p110) expression in mice.
Li J, Tang M, Ke RX, Li PL, Sheng ZG, Zhu BZ
Toxicology and applied pharmacology 2024 Jan;482:116765
Toxicology and applied pharmacology 2024 Jan;482:116765
The involvement of ADAR1 in chronic unpredictable stress-induced cognitive impairment by targeting DARPP-32 with miR-874-3p in BALB/c mice.
Wang Y, Liu Y, Zhao Z, Wu X, Lin J, Li Y, Yan W, Wu Y, Shi Y, Wu X, Xue Y, He J, Liu S, Zhang X, Xu H, Tang Y, Yin S
Frontiers in cell and developmental biology 2023;11:919297
Frontiers in cell and developmental biology 2023;11:919297
ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis.
Cai D, Fraunfelder M, Fujise K, Chen SY
Redox biology 2023 Nov;67:102903
Redox biology 2023 Nov;67:102903
Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.
Lu DQ, Yao XY, Ren YT, Zhang KY, Zhu XC, Hong T, Yu X, Xie ZM, Chen LY, Wang XC
International journal of rheumatic diseases 2023 Nov;26(11):2223-2232
International journal of rheumatic diseases 2023 Nov;26(11):2223-2232
Depleting DDX1 sensitizes non-small cell lung cancer cells to chemotherapy by attenuating cancer stem cell traits.
Yang Q, Xu P, Liu Q, Hu F, Xie X, Jiang L, Bi R, Wang L, Ding F, Xiao H
Life sciences 2023 Jun 15;323:121592
Life sciences 2023 Jun 15;323:121592
Atractylodes lancea volatile oils target ADAR2-miR-181a-5p signaling to mesenchymal stem cell chondrogenic differentiation.
Ye S, Si W, Qin W, Yang L, Luo Z, Li Z, Xie Y, Pan H, Li X, Huang Z, Zhu M, Chen D
Anatomical record (Hoboken, N.J. : 2007) 2023 Dec;306(12):3006-3020
Anatomical record (Hoboken, N.J. : 2007) 2023 Dec;306(12):3006-3020
Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis.
Chen W, Li Y, Ruan GX, Huang H, Zhang R, Wang J, Ouyang Y, Li Y, Xu S, Ou X
Cell reports 2022 Nov 22;41(8):111687
Cell reports 2022 Nov 22;41(8):111687
The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.
Hua H, Zeng J, Xing H, He Y, Han L, Zhang N, Yang M
Life sciences 2022 May 1;296:120408
Life sciences 2022 May 1;296:120408
Roles of miR-432 and circ_0000418 in mediating the anti-depressant action of ADAR1.
Zhang X, Yan W, Xue Y, Xu H, Li J, Zhao Z, Sun Y, Wang Y, He J, Huang Y, Yu D, Xiao Z, Yin S
Neurobiology of stress 2021 Nov;15:100396
Neurobiology of stress 2021 Nov;15:100396
The involvement of ADAR1 in antidepressant action by regulating BDNF via miR-432.
Zhang X, Xue Y, Li J, Xu H, Yan W, Zhao Z, Yu W, Zhai X, Sun Y, Wu Y, Li Y, Gui L, Yu D, Xiao Z, Yin S
Behavioural brain research 2021 Mar 26;402:113087
Behavioural brain research 2021 Mar 26;402:113087
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
Ma Y, Liu S, Gao J, Chen C, Zhang X, Yuan H, Chen Z, Yin X, Sun C, Mao Y, Zhou F, Shao Y, Liu Q, Xu J, Cheng L, Yu D, Li P, Yi P, He J, Geng G, Guo Q, Si Y, Zhao H, Li H, Banes GL, Liu H, Nakamura Y, Kurita R, Huang Y, Wang X, Wang F, Fang G, Engel JD, Shi L, Zhang YE, Yu J
Developmental cell 2021 Feb 22;56(4):478-493.e11
Developmental cell 2021 Feb 22;56(4):478-493.e11
The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.
Sun Y, Fan J, Wang B, Meng Z, Ren D, Zhao J, Liu Z, Li D, Jin X, Wu H
American journal of cancer research 2020;10(1):148-163
American journal of cancer research 2020;10(1):148-163
Decrease in ADAR1 expression by exposure to cigarette smoke enhances susceptibility to oxidative stress.
Takizawa M, Nakano M, Fukami T, Nakajima M
Toxicology letters 2020 Oct 1;331:22-32
Toxicology letters 2020 Oct 1;331:22-32
Increased AT(2)R expression is induced by AT(1)R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration.
Sun Y, Li Y, Wang M, Yue M, Bai L, Bian J, Hao W, Sun J, Zhang S, Liu H
Cell death & disease 2020 Jun 8;11(6):432
Cell death & disease 2020 Jun 8;11(6):432
LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer.
Wang W, Xie Y, Chen F, Liu X, Zhong LL, Wang HQ, Li QC
World journal of gastroenterology 2019 Aug 7;25(29):3972-3984
World journal of gastroenterology 2019 Aug 7;25(29):3972-3984
5-HT(2C)R antagonist/5-HT(2C)R inverse agonist recovered the increased isolation-induced aggressive behavior of BALB/c mice mediated by ADAR1 (p110) expression and Htr2c RNA editing.
Yu W, Xu H, Xue Y, An D, Li H, Chen W, Yu D, Sun Y, Ma J, Tang Y, Xiao Z, Yin S
Brain and behavior 2018 Mar;8(3):e00929
Brain and behavior 2018 Mar;8(3):e00929
Effects of social isolation and re-socialization on cognition and ADAR1 (p110) expression in mice.
Chen W, An D, Xu H, Cheng X, Wang S, Yu W, Yu D, Zhao D, Sun Y, Deng W, Tang Y, Yin S
PeerJ 2016;4:e2306
PeerJ 2016;4:e2306
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14330-1-AP( ADAR1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using ADAR antibody 14330-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-ADAR1 (IP:14330-1-AP, 4ug; Detection:14330-1-AP 1:500) with Y79 cells lysate 3000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 14330-1-AP(ADAR1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 14330-1-AP(ADAR1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
