14330-1-AP

antibody from Proteintech Group

Targeting: ADAR ADAR1, G1P1, IFI4

Provider product page for 14330-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 14330-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14330-1-AP, RRID:AB_2273600
Product name: ADAR1 antibody
Antibody type: Polyclonal
Description: ADAR1 antibody (Cat. #14330-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ADAR protein structure - 14330-1-AP shown in red.

Submitted references Inhibiting ADAR1-Mediated Excessive Epigenetic A-to-I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma.

Wang S, Zheng S, Liu C, Zhang C, Wang X, Wang Z, Wang Y, Feng X, Xue Q, Sun N, He J
MedComm 2026 Mar;7(3):e70574

Identification of A-to-I RNA editing profiles and their clinical relevance in pancreatic neuroendocrine neoplasms.

Xu Y, He N, Dai G, Zhou T, Ye M, Tang Q
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2025 Nov;25(7):1117-1125

Targeting ADAR1 with a small molecule for the treatment of prostate cancer.

Wang X, Li J, Zhu Y, Shen H, Ding J, Zeng T, Min W, Liang SQ, Huang L, Shi Z, Shen H, Huang F, Yuan K, Kuang W, Ji M, Sun C, Hou Y, Wang L, Chen W, Jiang Y, Hao H, Xiao Y, Yang P
Nature cancer 2025 Mar;6(3):474-492

Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.

Patel D, Tiusanen V, Karttunen K, Pihlajamaa P, Sahu B
Communications biology 2025 Jul 3;8(1):992

Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption.

Wang X, Lin S, Zou Z, Zhu D, Zhou J, Zhang X, Lv J, Zhou W, Liu Y, Si Z
Communications biology 2025 Dec 22;8(1):1832

ADAR1 enhances tumor proliferation and radioresistance in non-small cell lung cancer by interacting with Rad18.

Tian C, Li C, Wang J, Liu Y, Gao J, Hong X, Gu F, Zhang K, Hu Y, Fan H, Liu L, Zeng Y
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):471-485

Characterization of dsRNA binding proteins through solubility analysis identifies ZNF385A as a dsRNA homeostasis regulator.

Jiang N, Yang H, Lei Y, Qin W, Xiong H, Chen K, Mei K, Li G, Mu X, Chen R
Nature communications 2025 Apr 11;16(1):3433

ADAR promotes USP38 auto-deubiquitylation and stabilization in an RNA editing-independent manner in esophageal squamous cell carcinoma.

Hu Q, Chen Y, Zhou Q, Deng S, Hou W, Yi Y, Li C, Tang J
The Journal of biological chemistry 2024 Oct;300(10):107789

All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer.

Li CF, Bai LY, Wei Y, Lee HH, Yang R, Yao J, Wang H, Wang YN, Chang WC, Shen YC, Wang SC, Chou CW, Fu J, Ling J, Chu YY, Chiu CF, Wang M, Yu D, Chiao PJ, Liang H, Maitra A, Ying H, Hung MC
bioRxiv : the preprint server for biology 2024 Oct 23;

Targeting exosomal double-stranded RNA-TLR3 signaling pathway attenuates morphine tolerance and hyperalgesia.

Wang B, Le DS, Liu L, Zhang XX, Yang F, Lai GR, Zhang C, Zhao ML, Shen YP, Liao PS, Liu T, Liang YP
Cell reports. Medicine 2024 Oct 15;5(10):101782

Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.

Fan B, Li Y, Wang Y, Yang S, Peng Q, Qian J, Wang C, Zhang X, Xu H, Liu S, He W, Zhang G, Zhu X, Li Y, Zhao Y, Hu M, Wang W, Zhou J, Guo R, He K, Li B
Nucleic acids research 2024 Nov 27;52(21):13174-13191

The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.

Li J, Tang M, Ke RX, Li PL, Sheng ZG, Zhu BZ
Toxicology and applied pharmacology 2024 Jan;482:116765

Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis.

Li Z, Luo L, Ju X, Huang S, Lei L, Yu Y, Liu J, Zhang P, Chi T, Ma P, Huang C, Huang X, Ding Q, Zhang Y
The EMBO journal 2024 Dec;43(24):6444-6468

Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.

Ou N, Wang Y, Xu S, Luo J, Zhang C, Zhang Y, Shi X, Xiong M, Zhao L, Ji Z, Zhang Y, Zhao J, Bai H, Tian R, Li P, Zhi E, Huang Y, Chen W, Wang R, Jin Y, Wang D, Li Z, Chen H, Yao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692

The involvement of ADAR1 in chronic unpredictable stress-induced cognitive impairment by targeting DARPP-32 with miR-874-3p in BALB/c mice.

Wang Y, Liu Y, Zhao Z, Wu X, Lin J, Li Y, Yan W, Wu Y, Shi Y, Wu X, Xue Y, He J, Liu S, Zhang X, Xu H, Tang Y, Yin S
Frontiers in cell and developmental biology 2023;11:919297

ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis.

Cai D, Fraunfelder M, Fujise K, Chen SY
Redox biology 2023 Nov;67:102903

Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.

Lu DQ, Yao XY, Ren YT, Zhang KY, Zhu XC, Hong T, Yu X, Xie ZM, Chen LY, Wang XC
International journal of rheumatic diseases 2023 Nov;26(11):2223-2232

Depleting DDX1 sensitizes non-small cell lung cancer cells to chemotherapy by attenuating cancer stem cell traits.

Yang Q, Xu P, Liu Q, Hu F, Xie X, Jiang L, Bi R, Wang L, Ding F, Xiao H
Life sciences 2023 Jun 15;323:121592

Atractylodes lancea volatile oils target ADAR2-miR-181a-5p signaling to mesenchymal stem cell chondrogenic differentiation.

Ye S, Si W, Qin W, Yang L, Luo Z, Li Z, Xie Y, Pan H, Li X, Huang Z, Zhu M, Chen D
Anatomical record (Hoboken, N.J. : 2007) 2023 Dec;306(12):3006-3020

Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis.

Chen W, Li Y, Ruan GX, Huang H, Zhang R, Wang J, Ouyang Y, Li Y, Xu S, Ou X
Cell reports 2022 Nov 22;41(8):111687

The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.

Hua H, Zeng J, Xing H, He Y, Han L, Zhang N, Yang M
Life sciences 2022 May 1;296:120408

Roles of miR-432 and circ_0000418 in mediating the anti-depressant action of ADAR1.

Zhang X, Yan W, Xue Y, Xu H, Li J, Zhao Z, Sun Y, Wang Y, He J, Huang Y, Yu D, Xiao Z, Yin S
Neurobiology of stress 2021 Nov;15:100396

The involvement of ADAR1 in antidepressant action by regulating BDNF via miR-432.

Zhang X, Xue Y, Li J, Xu H, Yan W, Zhao Z, Yu W, Zhai X, Sun Y, Wu Y, Li Y, Gui L, Yu D, Xiao Z, Yin S
Behavioural brain research 2021 Mar 26;402:113087

Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.

Ma Y, Liu S, Gao J, Chen C, Zhang X, Yuan H, Chen Z, Yin X, Sun C, Mao Y, Zhou F, Shao Y, Liu Q, Xu J, Cheng L, Yu D, Li P, Yi P, He J, Geng G, Guo Q, Si Y, Zhao H, Li H, Banes GL, Liu H, Nakamura Y, Kurita R, Huang Y, Wang X, Wang F, Fang G, Engel JD, Shi L, Zhang YE, Yu J
Developmental cell 2021 Feb 22;56(4):478-493.e11

The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.

Sun Y, Fan J, Wang B, Meng Z, Ren D, Zhao J, Liu Z, Li D, Jin X, Wu H
American journal of cancer research 2020;10(1):148-163

Decrease in ADAR1 expression by exposure to cigarette smoke enhances susceptibility to oxidative stress.

Takizawa M, Nakano M, Fukami T, Nakajima M
Toxicology letters 2020 Oct 1;331:22-32

Increased AT(2)R expression is induced by AT(1)R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration.

Sun Y, Li Y, Wang M, Yue M, Bai L, Bian J, Hao W, Sun J, Zhang S, Liu H
Cell death & disease 2020 Jun 8;11(6):432

LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer.

Wang W, Xie Y, Chen F, Liu X, Zhong LL, Wang HQ, Li QC
World journal of gastroenterology 2019 Aug 7;25(29):3972-3984

5-HT(2C)R antagonist/5-HT(2C)R inverse agonist recovered the increased isolation-induced aggressive behavior of BALB/c mice mediated by ADAR1 (p110) expression and Htr2c RNA editing.

Yu W, Xu H, Xue Y, An D, Li H, Chen W, Yu D, Sun Y, Ma J, Tang Y, Xiao Z, Yin S
Brain and behavior 2018 Mar;8(3):e00929

Effects of social isolation and re-socialization on cognition and ADAR1 (p110) expression in mice.

Chen W, An D, Xu H, Cheng X, Wang S, Yu W, Yu D, Zhao D, Sun Y, Deng W, Tang Y, Yin S
PeerJ 2016;4:e2306

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 14330-1-AP( ADAR1 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using ADAR antibody 14330-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-ADAR1 (IP:14330-1-AP, 4ug; Detection:14330-1-AP 1:500) with Y79 cells lysate 3000ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human gliomas using 14330-1-AP(ADAR1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human gliomas using 14330-1-AP(ADAR1 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue