359507

antibody from BioLegend
Targeting: IL21R CD360
Provider product page for 359507

Antibody data

Product number
359507 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#359507, RRID:AB_2563187
Product name
APC anti-human CD360 (IL-21R)
Antibody type
Monoclonal
Antigen
Human IL-21R expressing mouse M1-T22 cell line.
Description
Human interleukin 21 receptor (IL-21R) is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits greatest extracellular homology to the IL-2R beta subunit (i.e., it contains one copy of the WSXWS-containing cytokine-binding domain). Intracellular domains of IL-21R include the Box 1 and Box 2 elements, which are similar to the IL-9R intracellular region. Upon binding IL-21, IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells, and can be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Reactivity
Human
Host
Mouse
Conjugate
Red dye
Antibody clone number
17A12
Vial size
25 tests
Storage
2°C-8°C
Handling
Ambient RT
IL21R protein structure - 359507 shown in red.