11225-1-AP

antibody from Proteintech Group

Targeting: MCM7 CDC47, MCM2, PPP1R104

Provider product page for 11225-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11225-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11225-1-AP, RRID:AB_2297584
Product name: MCM7 antibody
Antibody type: Polyclonal
Description: MCM7 antibody (Cat. #11225-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MCM7 protein structure - 11225-1-AP shown in red.

Submitted references Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways.

Liu B, Wang X, Wang Y, Zhang T, Guo R, Chen X, Zhang Z
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130947

Regulation of hemocyte proliferation by MCM7 in blood clam Anadara granosa against Vibrio parahaemolyticus infection.

Xu S, Wu B, Liu H, Bao Y
Fish & shellfish immunology 2026 Feb;169:111062

Claudin18.2 promote gastric cancer proliferation by activating MCM2/5.

Zheng B, Fu M, Lou F, He Y, Zhao L, Huang X, Xie X, Tan W, Chen Q, Zhang W, Hong Y, Rong K, Lu Y, Zhan P, Tu J, Shi H, Hu T, Xiao L
Scientific reports 2026 Feb 23;16(1)

Multi-omics integration reveals that pyrimidine metabolism in lung adenocarcinoma drives an immunosuppressive microenvironment.

Liu M, Li H, Xu S, Zhou Y, Yao M, Shi J, Zhong L
iScience 2026 Apr 17;29(4):115326

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.

Zhang J, Wang Y, Cao S, Xie SM, Liu B, Li Y, Hou Y, Meng X, Ruan M, Bu D, Kang J, Li R, Lou L, Wang J, Xing L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307

Host Cell Protein MCM7 Interacts with NP1 of Minute Virus of Canines and Facilitates Viral DNA Replication.

Hei Z, Ren X, Ji K, Zhang Z, Chen B, Sun Y
Microorganisms 2025 Sep 16;13(9)

CRL4(DCAF12) regulation of MCMBP ensures optimal licensing of DNA replication.

Yadav AK, Abdirov A, Ondruskova K, Negi S, Jamrichova K, Kolarova K, Dibus N, Krejci J, Polasek-Sedlackova H, Cermak L
Nature communications 2025 Oct 27;16(1):9391

DNA replication fork speed acts as a pacer in cortical neurogenesis.

Wang J, Kong Y, Li X, Chen D, Xiang K, Tan Y, Shi L
Nature communications 2025 Nov 18;16(1):10121

SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM.

Duan H, Wang S, Shu WJ, Tong Y, Long HZ, Li G, Du HN, Zhao MJ
Science China. Life sciences 2025 Mar;68(3):793-808

TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells.

Iwasa Y, Miyata S, Tomita T, Yokota N, Miyauchi M, Mori R, Matsushita S, Suzuki R, Saeki Y, Kawahara H
The Journal of cell biology 2025 Mar 3;224(3)

Histone lactylation facilitates MCM7 expression to maintain stemness and radio-resistance in hepatocellular carcinoma.

Liu Z, Han J, Su S, Zeng Q, Wu Z, Yuan J, Yang J
Biochemical pharmacology 2025 Jun;236:116887

Discovery and Mechanism of 16-19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells.

Shen Z, Yang X, Seabra G, Xu X, Dong J, Brant JO, Zhou W, Guan J, Jiang W, Li C
ACS chemical biology 2025 Jun 20;20(6):1333-1346

The EZH2/MCM Complex/hTERT axis facilitates hepatocellular carcinoma progression by inhibiting cellular senescence.

Shen Z, Wang Y, Gao J, Gu W, Ren Z, Xu L, Qian R, Miao Q, Hu X, Wu Y, Liu W, Cai Y, Wan CC, Zhu Y, Sun L, Yan T
Mechanisms of ageing and development 2025 Apr;224:112040

Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.

Nie Z, Liu Y, Xu L, Wang Y, Wang M, Zhou W, Zhu H, Zhao M, Wang S, Zhang H, Geng M, Peng M, Zeng H, Zhang Y, Zhu P, Shen W
Nanomedicine (London, England) 2025 Apr;20(8):803-816

BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer.

Liu N, Wang S, Li M, Zhao N, Wang D, Zhang R, Yu M, Zhao L, Zhang S, Han F, Zhao Y, Liu Q
Pharmacological research 2024 Oct;208:107377

Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes.

Wada T, Takeda Y, Okekawa A, Komatsu G, Iwasa Y, Onogi Y, Takasaki I, Hamashima T, Sasahara M, Tsuneki H, Sasaoka T
Scientific reports 2024 Oct 11;14(1):23829

miR-148a-3p regulates proliferation and apoptosis of idiopathic gingival fibroma by targeting NPTX1.

Sun Y, Xie L, Ren X, Ran L, He H, Kong F, Yang S, Zhang M
Oral diseases 2024 May;30(4):2136-2149

RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.

Feng X, Song D, Liu X, Liang Y, Jiang P, Wu S, Liu F
Oncology letters 2024 Mar;27(3):105

Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2.

Qin CM, Wei XW, Wu JY, Liu XQ, Lin Y
Reproduction (Cambridge, England) 2024 Mar 1;167(3)

Static Magnetic Field Promotes Proliferation, Migration, Differentiation, and AKT Activation of Periodontal Ligament Stem Cells.

Zhang K, Ge W, Luo S, Zhou Z, Liu Y
Cells, tissues, organs 2023;212(4):317-326

The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP.

Körner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A
eLife 2023 Sep 15;12

LncRNA BCAN-AS1 stabilizes c-Myc via N(6)-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer.

Wu G, Su J, Zeng L, Deng S, Huang X, Ye Y, Li R, Bai R, Zhuang L, Li M, Zhou Q, Zheng Y, Deng J, Zhang S, Chen R, Lin D, Zhang J, Zheng J
Cell death and differentiation 2023 Oct;30(10):2213-2230

Targeting CBX3 with a Dual BET/PLK1 Inhibitor Enhances the Antitumor Efficacy of CDK4/6 Inhibitors in Prostate Cancer.

Liang H, Yang C, Zeng R, Song Y, Wang J, Xiong W, Yan B, Jin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2302368

Systematic analysis of MCM3 in pediatric medulloblastoma via multi-omics analysis.

Liang Z, Yang J, Wang J, Tian S, Wang Q, Wang B, Zhao H, Jiang F, Ma J
Frontiers in molecular biosciences 2022;9:815260

Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5.

Qiu P, Jie Y, Ma C, Chen H, Qin Y, Tu K, Wang L, Zhang Z
Cell death discovery 2022 Jun 7;8(1):276

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling.

Zhao N, Gui X, Fang Q, Zhang R, Zhu W, Zhang H, Li Q, Zhou Y, Zhao J, Cui X, Gao G, Tang H, Shen N, Chen T, Song H, Shen W
Journal of nanobiotechnology 2022 Apr 2;20(1):174

MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.

Saito Y, Santosa V, Ishiguro KI, Kanemaki MT
eLife 2022 Apr 19;11

Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture.

Xu L, Su B, Mo L, Zhao C, Zhao Z, Li H, Hu Z, Li J
International journal of molecular sciences 2022 Apr 1;23(7)

DOCK7 protects against replication stress by promoting RPA stability on chromatin.

Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M, Billadeau DD, Lou Z
Nucleic acids research 2021 Apr 6;49(6):3322-3337

Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues Using PCT-SWATH.

Zhu Y, Zhu J, Lu C, Zhang Q, Xie W, Sun P, Dong X, Yue L, Sun Y, Yi X, Zhu T, Ruan G, Aebersold R, Huang S, Guo T
Proteomics. Clinical applications 2019 Jan;13(1):e1700179

Phenotypic transition of tumor cells between epithelial- and mesenchymal-like state during adaptation to acidosis.

Zhang Y, Xu L, Wang P, Jian H, Shi X, Jia M, Mo L, Hu Z, Li H, Li J
Cell cycle (Georgetown, Tex.) 2019 Aug;18(16):1938-1947

Expression and prognostic significance of MCM-3 and MCM-7 in salivary adenoid cystic carcinoma.

Wen QL, Zhu SM, Jiang LH, Xiang FY, Yin WJ, Qian YY, Huang YQ, Yin KX, Zhu X, Ge MH
International journal of clinical and experimental pathology 2018;11(11):5359-5369

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.

Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268

Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis.

Ma Y, Fei L, Zhang M, Zhang W, Liu X, Wang C, Luo Y, Zhang H, Han Y
Oncotarget 2017 Dec 1;8(62):104813-104830

Subcellular quantitative proteomics reveals multiple pathway cross-talk that coordinates specific signaling and transcriptional regulation for the early host response to LPS.

Du R, Long J, Yao J, Dong Y, Yang X, Tang S, Zuo S, He Y, Chen X
Journal of proteome research 2010 Apr 5;9(4):1805-21

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 11225-1-AP( MCM7 Antibody) at dilution of 1:3000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MCM7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MCM7. This antibody recognizes human,mouse,rat antigen. The MCM7 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 11225-1-AP.pdf

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