HPA027524

antibody from Atlas Antibodies

Targeting: ZEB1 AREB6, BZP, FECD6, NIL-2-A, PPCD3, TCF8, ZEB, Zfhep, Zfhx1a

Provider product page for HPA027524

Immunocytochemistry

Immunohistochemistry

Chromatin Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [109]
Comments [0]
Validations
Immunohistochemistry [1]
Chromatin Immunoprecipitation [1]

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Product number: HPA027524 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA027524, RRID:AB_1844977
Product name: Anti-ZEB1
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human ZEB1, Gene description: zinc finger E-box binding homeobox 1, Alternative Gene Names: AREB6, BZP, FECD6, NIL-2-A, PPCD3, TCF8, ZEB, Zfhep, Zfhx1a, Validated applications: IHC, ICC, ChIP, Uniprot ID: P37275, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.2 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

ZEB1 protein structure - HPA027524 shown in red.

Submitted references Proteogenomic characterization of pancreatic neuroendocrine tumors uncovers hypoxia and immune signatures in clinically aggressive subtypes

Tanaka A, Ogawa M, Zhou Y, Otani Y, Hendrickson R, Miele M, Li Z, Klimstra D, Wang J, Roehrl M
iScience 2024;27(8):110544

Cancer Cell Biomechanical Properties Accompany Tspan8-Dependent Cutaneous Melanoma Invasion

Runel G, Lopez-Ramirez N, Barbollat-Boutrand L, Cario M, Durand S, Grimont M, Schartl M, Dalle S, Caramel J, Chlasta J, Masse I
Cancers 2024;16(4):694

Cooperative pro-tumorigenic adaptation to oncogenic RAS through epithelial-to-mesenchymal plasticity

De Blander H, Tonon L, Fauvet F, Pommier R, Lamblot C, Benhassoun R, Angileri F, Gibert B, Rodriguez R, Ouzounova M, Morel A, Puisieux A
Science Advances 2024;10(7)

A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling

Zhu L, Tang Y, Li X, Kerk S, Lyssiotis C, Feng W, Sun X, Hespe G, Wang Z, Stemmler M, Brabletz S, Brabletz T, Keller E, Ma J, Cho J, Yang J, Weiss S
The EMBO Journal 2023;42(7)

A Novel Gemcitabine-Resistant Gallbladder Cancer Model Provides Insights into Molecular Changes Occurring during Acquired Resistance

Vergara-Gómez L, Bizama C, Zhong J, Buchegger K, Suárez F, Rosa L, Ili C, Weber H, Obreque J, Espinoza K, Repetto G, Roa J, Leal P, García P
International Journal of Molecular Sciences 2023;24(8):7238

Mesenchymal–epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression

Horny K, Sproll C, Peiffer L, Furtmann F, Gerhardt P, Gravemeyer J, Stoecklein N, Spassova I, Becker J
Journal of Translational Medicine 2023;21(1)

Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1

Trsova I, Hrustincova A, Krejcik Z, Kundrat D, Holoubek A, Staflova K, Janstova L, Vanikova S, Szikszai K, Klema J, Rysavy P, Belickova M, Kaisrlikova M, Vesela J, Cermak J, Jonasova A, Dostal J, Fric J, Musil J, Dostalova Merkerova M
Molecular Oncology 2023;17(12):2565-2583

An in vivo avian model of human melanoma to perform rapid and robust preclinical studies

Jarrosson L, Dalle S, Costechareyre C, Tang Y, Grimont M, Plaschka M, Lacourrège M, Teinturier R, Le Bouar M, Maucort‐Boulch D, Eberhardt A, Castellani V, Caramel J, Delloye‐Bourgeois C
EMBO Molecular Medicine 2023;15(3)

Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma

Ramesh V, Gollavilli P, Pinna L, Siddiqui M, Turtos A, Napoli F, Antonelli Y, Leal‐Egaña A, Havelund J, Jakobsen S, Boiteux E, Volante M, Færgeman N, Jensen O, Siersbæk R, Somyajit K, Ceppi P
EMBO Molecular Medicine 2023;15(12)

The study of miRNA-200c expression and epithelial-to-mesenchymal transition-related transcription factors in the primary bladder urothelial carcinoma

Narwal A, Kumari K, Kaushal S, Seth A, Nayak B, Rustagi Y, Dinda A
Urology Annals 2023;15(1):35-42

Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation

Martinez-Campanario M, Cortés M, Moreno-Lanceta A, Han L, Ninfali C, Domínguez V, Andrés-Manzano M, Farràs M, Esteve-Codina A, Enrich C, Díaz-Crespo F, Pintado B, Escolà-Gil J, García de Frutos P, Andrés V, Melgar-Lesmes P, Postigo A
Nature Communications 2023;14(1)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4

Bertrand-Chapel A, Caligaris C, Fenouil T, Savary C, Aires S, Martel S, Huchedé P, Chassot C, Chauvet V, Cardot-Ruffino V, Morel A, Subtil F, Mohkam K, Mabrut J, Tonon L, Viari A, Cassier P, Hervieu V, Castets M, Mauviel A, Sentis S, Bartholin L
Communications Biology 2022;5(1)

Micro-RNA-215 and -375 regulate thymidylate synthase protein expression in pleural mesothelioma and mediate epithelial to mesenchymal transition

Napoli F, Rapa I, Izzo S, Rigutto A, Libener R, Riganti C, Bironzo P, Taulli R, Papotti M, Volante M, Scagliotti G, Righi L
Virchows Archiv 2022;481(2):233-244

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation

Tang Y, Rockstroh A, Sokolowski K, Lynam L, Lehman M, Thompson E, Gregory P, Nelson C, Volpert M, Hollier B
Breast Cancer Research 2022;24(1)

HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells

Kim J, Han S, Yoo J, Kim G, Jeon Y, Lee S, Park J, Kwon S
International Journal of Molecular Sciences 2022;23(15):8645

Molecular and clinicopathological differences between depressed and protruded T2 colorectal cancer

Cheah P, Mochizuki K, Kudo S, Kato K, Kudo K, Ogawa Y, Kouyama Y, Takashina Y, Ichimasa K, Tobo T, Toshima T, Hisamatsu Y, Yonemura Y, Masuda T, Miyachi H, Ishida F, Nemoto T, Mimori K
PLOS ONE 2022;17(10):e0273566

SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis

Place E, Manning E, Kim D, Kinjo A, Nakamura G, Ohyama K
Frontiers in Neuroscience 2022;16

Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging

Freckmann E, Sandilands E, Cumming E, Neilson M, Román-Fernández A, Nikolatou K, Nacke M, Lannagan T, Hedley A, Strachan D, Salji M, Morton J, McGarry L, Leung H, Sansom O, Miller C, Bryant D
Nature Communications 2022;13(1)

A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes

Pedrosa L, Foguet C, Oliveres H, Archilla I, de Herreros M, Rodríguez A, Postigo A, Benítez-Ribas D, Camps J, Cuatrecasas M, Castells A, Prat A, Thomson T, Maurel J, Cascante M
Frontiers in Immunology 2022;13

Fibroblast activation protein identifies Consensus Molecular Subtype 4 in colorectal cancer and allows its detection by 68Ga-FAPI-PET imaging

Strating E, Wassenaar E, Verhagen M, Rauwerdink P, van Schelven S, de Hingh I, Rinkes I, Boerma D, Witkamp A, Lacle M, Fodde R, Volckmann R, Koster J, Stedingk K, Giesel F, de Roos R, Poot A, Bol G, Lam M, Elias S, Kranenburg O
British Journal of Cancer 2022;127(1):145-155

Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits.

Rodriguez E, Boelaars K, Brown K, Madunić K, van Ee T, Dijk F, Verheij J, Li RJE, Schetters STT, Meijer LL, Le Large TYS, Driehuis E, Clevers H, Bruijns SCM, O'Toole T, van Vliet SJ, Bijlsma MF, Wuhrer M, Kazemier G, Giovannetti E, Garcia-Vallejo JJ, van Kooyk Y
Communications biology 2022 Jan 11;5(1):41

ELK3 Mediated by ZEB1 Facilitates the Growth and Metastasis of Pancreatic Carcinoma by Activating the Wnt/β-Catenin Pathway

Zhao Q, Ren Y, Xie H, Yu L, Lu J, Jiang W, Xiao W, Zhu Z, Wan R, Li B
Frontiers in Cell and Developmental Biology 2021;9

MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer

Williams M, Christenson J, O’Neill K, Hafeez S, Ihle C, Spoelstra N, Slansky J, Richer J
npj Breast Cancer 2021;7(1)

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Casanova-Acebes M, Dalla E, Leader A, LeBerichel J, Nikolic J, Morales B, Brown M, Chang C, Troncoso L, Chen S, Sastre-Perona A, Park M, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai C, Agulló-Pascual E, Schober M, Brown B, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso J, Merad M
Nature 2021;595(7868):578-584

Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population

Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares J, Reina-Campos M, Kudo Y, L’Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello D, Batlle E, Diaz-Meco M, Moscat J
Developmental Cell 2021;56(1):95-110.e10

The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus

Gupta B, Errington A, Jimenez-Pascual A, Eftychidis V, Brabletz S, Stemmler M, Brabletz T, Petrik D, Siebzehnrubl F
Cell Reports 2021;36(8):109588

A Multi-Omics Network of a Seven-Gene Prognostic Signature for Non-Small Cell Lung Cancer

Ye Q, Falatovich B, Singh S, Ivanov A, Eubank T, Guo N
International Journal of Molecular Sciences 2021;23(1):219

Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer

Ye Q, Mohamed R, Dakhlallah D, Gencheva M, Hu G, Pearce M, Kolluri S, Marsh C, Eubank T, Ivanov A, Guo N
International Journal of Molecular Sciences 2021;22(7):3752

Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis

Addison J, Voronkova M, Fugett J, Lin C, Linville N, Trinh B, Livengood R, Smolkin M, Schaller M, Ruppert J, Pugacheva E, Creighton C, Ivanov A
Molecular Cancer Research 2021;19(5):784-798

PD-L1 as a Prognostic Factor in Early-Stage Colon Carcinoma within the Immunohistochemical Molecular Subtype Classification

Azcue P, Encío I, Guerrero Setas D, Suarez Alecha J, Galbete A, Mercado M, Vera R, Gomez-Dorronsoro M
Cancers 2021;13(8):1943

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs)

Koch K, Hartmann R, Suwala A, Rios D, Kamp M, Sabel M, Steiger H, Willbold D, Sharma A, Kahlert U, Maciaczyk J
Cancers 2021;13(23):6001

Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells

Kumar-Singh A, Parniewska M, Giotopoulou N, Javadi J, Sun W, Szatmári T, Dobra K, Hjerpe A, Fuxe J
Biology 2021;10(6):521

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

Verhagen M, Teeuwssen M, Sacchetti A, Joosten R, Xu T, Stabile R, van der Steen B, Watson M, Gusinac A, Kim W, Ubink I, Van de Werken H, Fumagalli A, Paauwe M, Van Rheenen J, Sansom O, Kranenburg O, Fodde R
eLife 2021;10

Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

Tian C, Öhlund D, Rickelt S, Lidström T, Huang Y, Hao L, Zhao R, Franklin O, Bhatia S, Tuveson D, Hynes R
Cancer Research 2020;80(7):1461-1474

Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma

Liu D, Steins A, Klaassen R, van der Zalm A, Bennink R, van Tienhoven G, Besselink M, Bijlsma M, van Laarhoven H
Biomedicines 2020;8(11):444

A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

Koch K, Hartmann R, Tsiampali J, Uhlmann C, Nickel A, He X, Kamp M, Sabel M, Barker R, Steiger H, Hänggi D, Willbold D, Maciaczyk J, Kahlert U
Cell Death Discovery 2020;6(1)

Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

Feldker N, Ferrazzi F, Schuhwerk H, Widholz S, Guenther K, Frisch I, Jakob K, Kleemann J, Riegel D, Bönisch U, Lukassen S, Eccles R, Schmidl C, Stemmler M, Brabletz T, Brabletz S
The EMBO Journal 2020;39(17)

Immunohistochemistry-Based Consensus Molecular Subtypes as a Prognostic and Predictive Biomarker for Adjuvant Chemotherapy in Patients with Stage II Colorectal Cancer

Li Y, Yao Q, Zhang L, Mo S, Cai S, Huang D, Peng J
The Oncologist 2020;25(12):e1968-e1979

RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells

Fritz A, Hong D, Boyd J, Kost J, Finstaad K, Fitzgerald M, Hanna S, Abuarqoub A, Malik M, Bushweller J, Tye C, Ghule P, Gordon J, Frietze S, Zaidi S, Lian J, Stein J, Stein G
Journal of Cellular Physiology 2020;235(10):7261-7272

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

Recouvreux M, Moldenhauer M, Galenkamp K, Jung M, James B, Zhang Y, Lowy A, Bagchi A, Commisso C
Journal of Experimental Medicine 2020;217(9)

High‐grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF‐1

Steins A, van Mackelenbergh M, van der Zalm A, Klaassen R, Serrels B, Goris S, Kocher H, Waasdorp C, de Jong J, Tekin C, Besselink M, Busch O, van de Vijver M, Verheij J, Dijk F, van Tienhoven G, Wilmink J, Medema J, van Laarhoven H, Bijlsma M
EMBO reports 2020;21(5)

Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression

Kojima M, Kajino K, Momose S, Wali N, Hlaing M, Han B, Yue L, Abe M, Fujii T, Ikeda K, Hino O
Respiratory Research 2020;21(1)

Expression of Selected Epithelial‐Mesenchymal Transition Transcription Factors in Endometrial Cancer

Sadłecki P, Jóźwicki J, Antosik P, Walentowicz-Sadłecka M, Todorov P
BioMed Research International 2020;2020(1)

Enzymatic Activity of CD73 Modulates Invasion of Gliomas via Epithelial–Mesenchymal Transition-Like Reprogramming

Tsiampali J, Neumann S, Giesen B, Koch K, Maciaczyk D, Janiak C, Hänggi D, Maciaczyk J
Pharmaceuticals 2020;13(11):378

New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer

D’Alterio C, Zannetti A, Trotta A, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
Cancers 2020;12(7):1952

Tumor-Suppressive miR-192-5p Has Prognostic Value in Pancreatic Ductal Adenocarcinoma

Flammang I, Reese M, Ströse A, Yang Z, Eble J, Dhayat S
Cancers 2020;12(6):1693

OVOL2-Mediated ZEB1 Downregulation May Prevent Promotion of Actinic Keratosis to Cutaneous Squamous Cell Carcinoma.

Murata M, Ito T, Tanaka Y, Yamamura K, Furue K, Furue M
Journal of clinical medicine 2020 Feb 25;9(3)

MEK1 Inhibitor Combined with Irradiation Reduces Migration of Breast Cancer Cells Including miR-221 and ZEB1 EMT Marker Expression.

Anastasov N, Hirmer E, Klenner M, Ott J, Falkenberg N, Bao X, Mutschelknaus L, Moertl S, Combs S, Atkinson MJ, Schmid T
Cancers 2020 Dec 14;12(12)

HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer

Yang H, Liang S, Xu D, Yang Z, Marti T, Gao Y, Kocher G, Zhao H, Schmid R, Peng R
Oncogenesis 2019;8(9)

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

Yoshimoto S, Tanaka F, Morita H, Hiraki A, Hashimoto S
Cancer Medicine 2019;8(18):7822-7832

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

Franke F, Müller J, Abal M, Medina E, Nitsche U, Weidmann H, Chardonnet S, Ninio E, Janssen K
Cellular and Molecular Gastroenterology and Hepatology 2019;7(1):33-53

Downregulation of Nodal inhibits metastatic progression in retinoblastoma

Asnaghi L, White D, Yoon L, Price A, Lee G, Sahoo A, Mumm J, Eberhart C
Acta Neuropathologica Communications 2019;7(1)

Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity

Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A
Life Science Alliance 2019;2(4):e201900425

Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression

Rogers T, Christenson J, Greene L, O'Neill K, Williams M, Gordon M, Nemkov T, D'Alessandro A, Degala G, Shin J, Tan A, Cittelly D, Lambert J, Richer J
Molecular Cancer Research 2019;17(1):30-41

Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling

de la Cuesta F, Passalacqua I, Rodor J, Bhushan R, Denby L, Baker A
Cell Communication and Signaling 2019;17(1)

Cancer-associated stroma significantly contributes to the mesenchymal subtype signature of serous ovarian cancer

Zhang Q, Wang C, Cliby W
Gynecologic Oncology 2019;152(2):368-374

Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes

Katoh M, Hirano D, Urabe Y, Tanaka S, Nakamura K, Ninomiya Y, Yuge R, Hayashi R, Oka S, Kitadai Y, Shimamoto F, Arihiro K, Chayama K
PLOS ONE 2019;14(2):e0211477

PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

Filipović J, Bosić M, Ćirović S, Životić M, Dunđerović D, Đorđević D, Živković-Perišić S, Lipkovski A, Marković-Lipkovski J
Diagnostic Pathology 2019;14(1)

Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling

Kim Y, Lee S, Shim S, Kim A, Park J, Jang W, Lee S, Myung J, Park S, Lee S, Kim M
Cancer Science 2019;110(7):2226-2236

ZEB1 protects skeletal muscle from damage and is required for its regeneration

Siles L, Ninfali C, Cortés M, Darling D, Postigo A
Nature Communications 2019;10(1)

Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E-box-binding homeobox 1 expression.

Harada H, Hosoda K, Moriya H, Mieno H, Ema A, Washio M, Kikuchi M, Kosaka Y, Watanabe M, Yamashita K
Oncology letters 2019 Jan;17(1):578-586

Quantitative Analysis of Micrornas in Tissue Microarrays by in Situ Hybridization

Hanna J, Wimberly H, Kumar S, Slack F, Agarwal S, Rimm D
BioTechniques 2018;52(4):235-245

ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma

Asnaghi L, White D, Key N, Choi J, Mahale A, Alkatan H, Edward D, Elkhamary S, Al-Mesfer S, Maktabi A, Hurtado C, Lee G, Carcaboso A, Mumm J, Safieh L, Eberhart C
Oncogene 2018;38(12):2056-2075

Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma

Hoang‐Minh L, Siebzehnrubl F, Yang C, Suzuki‐Hatano S, Dajac K, Loche T, Andrews N, Schmoll Massari M, Patel J, Amin K, Vuong A, Jimenez‐Pascual A, Kubilis P, Garrett T, Moneypenny C, Pacak C, Huang J, Sayour E, Mitchell D, Sarkisian M, Reynolds B, Deleyrolle L
The EMBO Journal 2018;37(23)

Zeb1 potentiates genome‐wide gene transcription with Lef1 to promote glioblastoma cell invasion

Rosmaninho P, Mükusch S, Piscopo V, Teixeira V, Raposo A, Warta R, Bennewitz R, Tang Y, Herold‐Mende C, Stifani S, Momma S, Castro D
The EMBO Journal 2018;37(15)

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

Jolly M, Preca B, Tripathi S, Jia D, George J, Hanash S, Brabletz T, Stemmler M, Maurer J, Levine H
APL Bioengineering 2018;2(3)

Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells

Roumane A, Berthenet K, El Fassi C, Ichim G
BMC Cell Biology 2018;19(1)

Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor

Hong D, Fritz A, Finstad K, Fitzgerald M, Weinheimer A, Viens A, Ramsey J, Stein J, Lian J, Stein G
Molecular Cancer Research 2018;16(12):1952-1964

Clinical Impact of Epithelial-to-Mesenchymal Transition Regulating MicroRNAs in Pancreatic Ductal Adenocarcinoma

Dhayat S, Traeger M, Rehkaemper J, Stroese A, Steinestel K, Wardelmann E, Kabar I, Senninger N
Cancers 2018;10(9):328

PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer.

Tekin C, Shi K, Daalhuisen JB, Ten Brink MS, Bijlsma MF, Spek CA
Oncotarget 2018 Aug 10;9(62):32010-32023

Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3

Ninfali C, Siles L, Darling D, Postigo A
Nucleic Acids Research 2018

EMT induced by loss of LKB1 promotes migration and invasion of liver cancer cells through ZEB1‑induced YAP signaling

Qiu B, Wei W, Zhu J, Fu G, Lu D
Oncology Letters 2018

Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts

Ball C, Oppel F, Ehrenberg K, Dubash T, Dieter S, Hoffmann C, Abel U, Herbst F, Koch M, Werner J, Bergmann F, Ishaque N, Schmidt M, von Kalle C, Scholl C, Fröhling S, Brors B, Weichert W, Weitz J, Glimm H
EMBO Molecular Medicine 2017;9(7):918-932

A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer

Preca B, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, Matzge-Ogi A, Orian-Rousseau V, Brabletz S, Brabletz T, Maurer J, Stemmler M
Oncotarget 2017;8(7):11530-11543

Phytosphingosine exhibits an anti-epithelial–mesenchymal transition function by the inhibition of EGFR signaling in human breast cancer cells

Kang H, Son H, Cui Y, Youn B, Son B, Kaushik N, Uddin N, Lee J, Song J, Kaushik N, Lee S
Oncotarget 2017;8(44):77794-77808

Tumor‐associated macrophages (TAMs) depend on ZEB1 for their cancer‐promoting roles

Cortés M, Sanchez‐Moral L, de Barrios O, Fernández‐Aceñero M, Martínez‐Campanario M, Esteve‐Codina A, Darling D, Győrffy B, Lawrence T, Dean D, Postigo A
The EMBO Journal 2017;36(22):3336-3355

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

Krebs A, Mitschke J, Lasierra Losada M, Schmalhofer O, Boerries M, Busch H, Boettcher M, Mougiakakos D, Reichardt W, Bronsert P, Brunton V, Pilarsky C, Winkler T, Brabletz S, Stemmler M, Brabletz T
Nature Cell Biology 2017;19(5):518-529

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming

Mishra P, Tang W, Putluri V, Dorsey T, Jin F, Wang F, Zhu D, Amable L, Deng T, Zhang S, Killian J, Wang Y, Minas T, Yfantis H, Lee D, Sreekumar A, Bustin M, Liu W, Putluri N, Ambs S
Journal of Clinical Investigation 2017;128(1):323-340

Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma

Ulasov I, Euskirchen P, Radke J, Schmidt M, Schulze Heuling E, Kadikowski E, Maricos M, Knab F, Grittner U, Zerbe N, Czabanka M, Dieterich C, Miletic H, Mørk S, Koch A, Endres M, Harms C
PLOS ONE 2017;12(9):e0185376

Distinguishing mechanisms underlying EMT tristability

Jia D, Jolly M, Tripathi S, Den Hollander P, Huang B, Lu M, Celiktas M, Ramirez-Peña E, Ben-Jacob E, Onuchic J, Hanash S, Mani S, Levine H
Cancer Convergence 2017;1(1)

Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition.

Larsson C, Ali MA, Pandzic T, Lindroth AM, He L, Sjöblom T
BMC cancer 2017 Jul 17;17(1):487

Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial–mesenchymal transition phenotype

Sakuma Y, Nishikiori H, Hirai S, Yamaguchi M, Yamada G, Watanabe A, Hasegawa T, Kojima T, Niki T, Takahashi H
Laboratory Investigation 2016;96(4):391-398

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Fessler E, Drost J, van Hooff S, Linnekamp J, Wang X, Jansen M, De Sousa E Melo F, Prasetyanti P, IJspeert J, Franitza M, Nürnberg P, van Noesel C, Dekker E, Vermeulen L, Clevers H, Medema J
EMBO Molecular Medicine 2016;8(7):745-760

Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells

Koch K, Hartmann R, Schröter F, Suwala A, Maciaczyk D, Krüger A, Willbold D, Kahlert U, Maciaczyk J
Oncotarget 2016;7(45):73414-73431

Loss of zfp36 expression in colorectal cancer correlates to wnt/ β-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1

Montorsi L, Guizzetti F, Alecci C, Caporali A, Martello A, Atene C, Parenti S, Pizzini S, Zanovello P, Bortoluzzi S, Ferrari S, Grande A, Zanocco-Marani T
Oncotarget 2016;7(37):59144-59157

Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer

Kim R, Kaushik N, Suh Y, Yoo K, Cui Y, Kim M, Lee H, Kim I, Lee S
Oncotarget 2016;7(33):53430-53442

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, Herr R, Brabletz S, Stemmler M, Brabletz T
Nature Communications 2016;7(1)

Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition

Singh S, Howell D, Trivedi N, Kessler K, Ong T, Rosmaninho P, Raposo A, Robinson G, Roussel M, Castro D, Solecki D
eLife 2016;5

Expression of zinc finger E-box-binding homeobox factor 1 in epithelial ovarian cancer: A clinicopathological analysis of 238 patients

LI X, HUANG R, LI R, TROPE C, NESLAND J, SUO Z
Molecular and Clinical Oncology 2016;4(1):18-22

Resetting cancer stem cell regulatory nodes upon MYC inhibition

Galardi S, Savino M, Scagnoli F, Pellegatta S, Pisati F, Zambelli F, Illi B, Annibali D, Beji S, Orecchini E, Alberelli M, Apicella C, Fontanella R, Michienzi A, Finocchiaro G, Farace M, Pavesi G, Ciafrè S, Nasi S
EMBO reports 2016;17(12):1872-1889

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach.

Flanagan L, Meyer M, Fay J, Curry S, Bacon O, Duessmann H, John K, Boland KC, McNamara DA, Kay EW, Bantel H, Schulze-Bergkamen H, Prehn JH
Cell death & disease 2016 Feb 4;7(2):e2087

ZEB 1‐associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

Meidhof S, Brabletz S, Lehmann W, Preca B, Mock K, Ruh M, Schüler J, Berthold M, Weber A, Burk U, Lübbert M, Puhr M, Culig Z, Wellner U, Keck T, Bronsert P, Küsters S, Hopt U, Stemmler M, Brabletz T
EMBO Molecular Medicine 2015;7(6):831-847

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

Sundararajan V, Gengenbacher N, Stemmler M, Kleemann J, Brabletz T, Brabletz S
Oncotarget 2015;6(29):27083-27096

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

Mock K, Preca B, Brummer T, Brabletz S, Stemmler M, Brabletz T
Oncotarget 2015;6(16):14399-14412

Stromal contribution to the colorectal cancer transcriptome

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SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150

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EMT-associated factors promote invasive properties of uveal melanoma cells.

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Epithelial-Mesenchymal Transition Induces Endoplasmic-Reticulum-Stress Response in Human Colorectal Tumor Cells

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CD95 and CD95L promote and protect cancer stem cells

Ceppi P, Hadji A, Kohlhapp F, Pattanayak A, Hau A, Liu X, Liu H, Murmann A, Peter M
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Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation

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Cell Cycle 2014;12(14):2309-2320

Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

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Epithelial to Mesenchymal Transition in Murine Tracheal Allotransplantation: An Immunohistochemical Observation

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The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells

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Dual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer

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Journal of Biological Chemistry 2013;288(32):22993-23008

Zeb1 Regulates E-cadherin and Epcam (Epithelial Cell Adhesion Molecule) Expression to Control Cell Behavior in Early Zebrafish Development

Vannier C, Mock K, Brabletz T, Driever W
Journal of Biological Chemistry 2013;288(26):18643-18659

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

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Nature Medicine 2013;19(5):614-618

Overexpression of ZEB1 associated with metastasis and invasion in patients with gastric carcinoma

Jia B, Liu H, Kong Q, Li B
Molecular and Cellular Biochemistry 2012;366(1-2):223-229

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human cerebral cortex and liver tissues using HPA027524 antibody. Corresponding ZEB1 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: ChIP-Exo-Seq composite graph for Anti-ZEB1 (HPA027524, Lot 000041609) tested in K562 cells. Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site. Data generated by Prof. B. F. Pugh´s Lab at Cornell University.