ZEB1

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Description

zinc finger E-box binding homeobox 1

Protein family

Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

10:p11.22 (31318495 - 31529814)

Ensembl ID

ENSG00000148516  (ver. 99.38)

Orthologs

Mouse Zeb1: ENSMUSG00000024238

UniProt

P37275

neXtProt

NX_P37275

Human splice variants
Mouse splice variants