21544-1-AP

antibody from Proteintech Group

Targeting: ZEB1 AREB6, BZP, FECD6, NIL-2-A, PPCD3, TCF8, ZEB, Zfhep, Zfhx1a

Provider product page for 21544-1-AP

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Antibody data

Antibody Data
Antigen structure
References [217]
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Product number: 21544-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21544-1-AP, RRID:AB_10734325
Product name: ZEB1 antibody
Antibody type: Polyclonal
Description: ZEB1 antibody (Cat. #21544-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ZEB1 protein structure - 21544-1-AP shown in red.

Submitted references Toosendanin Restrains Idiopathic Pulmonary Fibrosis by Inhibiting ZEB1/CTBP1 Interaction.

Li X, Bai Z, Li Z, Wang J, Yan X
Current molecular medicine 2024;24(1):123-133

PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids.

Jia R, Shao S, Zhang P, Yuan Y, Rong W, An Z, Lv S, Feng Y, Liu N, Feng Q, Wang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155795

Regulation mechanism of EBV-encoded EBER1 and LMP2A on YAP1 and the impact of YAP1 on the EBV infection status in EBV-associated gastric carcinoma.

Sun Y, Shi D, Sun J, Zhang Y, Liu W, Luo B
Virus research 2024 May;343:199352

Integrating single-cell and spatial analysis reveals MUC1-mediated cellular crosstalk in mucinous colorectal adenocarcinoma.

Zhou H, Shen Y, Zheng G, Zhang B, Wang A, Zhang J, Hu H, Lin J, Liu S, Luan X, Zhang W
Clinical and translational medicine 2024 May;14(5):e1701

Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model.

Sun Z, Xu Y, Shao B, Dang P, Hu S, Sun H, Chen C, Wang C, Liu J, Liu Y, Hu J
Journal for immunotherapy of cancer 2024 May 23;12(5)

IL-6 regulates epithelial ovarian cancer EMT, invasion, and metastasis by modulating Let-7c and miR-200c through the STAT3/HIF-1α pathway.

Guo QY, Song JN, Chen YM, Yuan HN, Xue WS, Sun Y, Niu XL, Wang Y, Chen X
Medical oncology (Northwood, London, England) 2024 May 14;41(6):155

Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.

Feng S, Ding B, Dai Z, Yin H, Ding Y, Liu S, Zhang K, Lin H, Xiao Z, Shen Y
Journal of translational medicine 2024 Mar 15;22(1):280

Astragaloside IV inhibits epithelial-mesenchymal transition and pulmonary fibrosis via lncRNA-ATB/miR-200c/ZEB1 signaling pathway.

Guan Y, Zhang J, Cai X, Cai Y, Song Z, Huang Y, Qian W, Pan Z, Zhang X
Gene 2024 Mar 1;897:148040

PPP2R1B abolishes colorectal cancer liver metastasis and sensitizes Oxaliplatin by inhibiting MAPK/ERK signaling pathway.

Liu W, Tang J, Gao W, Sun J, Liu G, Zhou J
Cancer cell international 2024 Mar 1;24(1):90

Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.

Li T, Wei L, Zhang X, Fu B, Zhou Y, Yang M, Cao M, Chen Y, Tan Y, Shi Y, Wu L, Xuan C, Du Q, Hu R
Molecular cancer research : MCR 2024 Jun 4;22(6):538-554

Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.

Zhu S, Meng L, Wei P, Gu G, Duan K
Translational cancer research 2024 Jan 31;13(1):348-362

PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma.

Li Q, Li J, Wang J, Wang J, Lu T, Jia Y, Sun H, Ma X
Molecular carcinogenesis 2024 Feb;63(2):253-265

NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.

Hu H, Li B, Chen H, Fan G, Ye Z, Ji S, Yu X, Xu X, Qin Y
Molecular carcinogenesis 2024 Feb;63(2):195-208

A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation.

Chen L, Xu G, Song X, Zhang L, Chen C, Xiang G, Wang S, Zhang Z, Wu F, Yang X, Zhang L, Ma X, Yu J
Cancer letters 2024 Feb 28;583:216635

Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma.

Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ
Nature communications 2024 Feb 20;15(1):1532

Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines.

Stachowicz-Suhs M, Łabędź N, Anisiewicz A, Banach J, Kłopotowska D, Milczarek M, Piotrowska A, Dzięgiel P, Maciejczyk A, Matkowski R, Wietrzyk J
Scientific reports 2024 Feb 15;14(1):3778

RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.

Dong W, Li X, Cheng L, Yang J, Zhao Z, Qiang X, Li P, Wu J, Guo L
Archives of biochemistry and biophysics 2024 Apr;754:109896

Lithium chloride promotes mesenchymal-epithelial transition in murine cutaneous wound healing via inhibiting CXCL9 and IGF2.

Zhang C, Luo X, Wei M, Jing B, Wang J, Lin L, Shi B, Zheng Q, Li C
Experimental dermatology 2024 Apr;33(4):e15078

GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway.

Ding Y, Wang Z, Zhang Z, You R, Wu Y, Bian T
Respiratory research 2024 Apr 9;25(1):158

C6orf15 promotes liver metastasis via WNT/β-catenin signalling in colorectal cancer.

Yu J, Sun J, Tang J, Xu J, Qian G, Zhou J
Cancer cell international 2024 Apr 23;24(1):146

SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation.

Yuan J, Zhu Z, Zhang P, Ashrafizadeh M, Abd El-Aty AM, Hacımüftüoğlu A, Linnebacher CS, Linnebacher M, Sethi G, Gong P, Zhang X
Cancer letters 2024 Apr 10;587:216733

Combined therapy of dabrafenib and an anti-HER2 antibody-drug conjugate for advanced BRAF-mutant melanoma.

Li W, Zheng C, Xu X, Xia Y, Zhang K, Huang A, Zhang X, Zheng Y, Chen G, Zhang S
Cellular & molecular biology letters 2024 Apr 10;29(1):50

NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner.

Zhou Y, Qian W, Li X, Wei W
Oxidative medicine and cellular longevity 2023;2023:7098313

LncRNA SNHG5 Suppresses Cell Migration and Invasion of Human Lung Adenocarcinoma via Regulation of Epithelial-Mesenchymal Transition.

Li Z, Wu Y, Zhang C, Dai S, Wei S, Zhao R, Gao F, Zhao L, Shan B
Journal of oncology 2023;2023:3335959

Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis.

Zhai D, Zhou Y, Kuang X, Shao F, Zhen T, Lin Y, Wang Q, Shao N
International journal of medical sciences 2023;20(9):1152-1162

Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells.

Wang X, Chen D, Han G, Wang X, Liu X, Xu B, Liu W, Li H, Zhang M, Ma S, Han Y
Open medicine (Warsaw, Poland) 2023;18(1):20230669

HDAC5-mediated PRAME regulates the proliferation, migration, invasion, and EMT of laryngeal squamous cell carcinoma via the PI3K/AKT/mTOR signaling pathway.

Yu L, Cao H, Yang JW, Meng WX, Yang C, Wang JT, Yu MM, Wang BS
Open medicine (Warsaw, Poland) 2023;18(1):20230665

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.

Wang H, Lin F, Xu Z, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B, Li Q
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556

LOXL1 and LOXL4 are novel target genes of the Zn(2+)-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells.

Hirabayashi D, Yamamoto KI, Maruyama A, Tomonobu N, Kinoshita R, Chen Y, Komalasari NLGY, Murata H, Gohara Y, Jiang F, Zhou J, Ruma IMW, Sumardika IW, Yamauchi A, Kuribayashi F, Toyooka S, Inoue Y, Sakaguchi M
Frontiers in oncology 2023;13:1142886

Exploration and validation of the influence of angiogenesis-related factors in aortic valve calcification.

Kong X, Meng L, Wei K, Lv X, Liu C, Lin F, Gu X
Frontiers in cardiovascular medicine 2023;10:1061077

LINC00426, a novel m(6)A-regulated long non-coding RNA, induces EMT in cervical cancer by binding to ZEB1.

Shen S, Jin H, Zhang X, Zhang Y, Li X, Yan W, Xie S, Yu B, Hu J, Liu H, Chen X, Nie Y, Liu F, Tang M, Gu Y, Wang S
Cellular signalling 2023 Sep;109:110788

A circular RNA activated by TGFβ promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability.

Li K, Guo J, Ming Y, Chen S, Zhang T, Ma H, Fu X, Wang J, Liu W, Peng Y
Nature communications 2023 Oct 28;14(1):6876

The CPT1A/Snail axis promotes pancreatic adenocarcinoma progression and metastasis by activating the glycolytic pathway.

Yang S, Liu Y, Tang C, Han A, Lin Z, Quan J, Yang Y
iScience 2023 Oct 20;26(10):107869

The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells.

Wang Y, Zhang Q, He T, Wang Y, Lu T, Wang Z, Wang Y, Lin S, Yang K, Wang X, Xie J, Zhou Y, Hong Y, Liu WH, Mao K, Cheng SC, Chen X, Li Q, Xiao N
Nature communications 2023 Oct 20;14(1):6639

LKB1 loss promotes colorectal cancer cell metastasis through regulating TNIK expression and actin cytoskeleton remodeling.

Hu G, Huang N, Zhang J, Zhang D, Wang S, Zhang Y, Wang L, Du Y, Kuang S, Ma K, Zhu H, Xu N, Liu M
Molecular carcinogenesis 2023 Nov;62(11):1659-1672

Macrophage microvesicle-derived circ_YTHDF2 in methamphetamine-induced chronic lung injury.

Chen L, Gu YJ, Zhang XG, Cheng L, Zhou MY, Yang Y, Wang Y
The Journal of physiology 2023 Nov;601(22):5107-5128

The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.

Ninfali C, Cortés M, Martínez-Campanario MC, Domínguez V, Han L, Tobías E, Esteve-Codina A, Enrich C, Pintado B, Garrabou G, Postigo A
Proceedings of the National Academy of Sciences of the United States of America 2023 Nov 14;120(46):e2301120120

TJP3 promotes T cell immunity escape and chemoresistance in breast cancer: a comprehensive analysis of anoikis-based prognosis prediction and drug sensitivity stratification.

Chaojun L, Pengping L, Yanjun L, Fangyuan Z, Yaning H, Yingbo S, Qi C, Hui L
Aging 2023 Nov 10;15(22):12890-12906

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

Li Y, Huang X, Jin J, Zhang H, Yang K, Han J, Lv Y, Sun Y, Yao C, Lin T, Zhu C, Liu H
Cell & bioscience 2023 May 6;13(1):80

N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.

Yu XM, Li SJ, Yao ZT, Xu JJ, Zheng CC, Liu ZC, Ding PB, Jiang ZL, Wei X, Zhao LP, Shi XY, Li ZG, Xu WW, Li B
Oncogene 2023 Mar;42(14):1101-1116

USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.

Zeng K, Xie W, Wang C, Wang S, Liu W, Su Y, Lin L, Zou R, Sun G, Zhou B, Wang M, Luan R, Bai Y, Huo Y, Kato S, Zhong X, Zhao Y
Cell death & disease 2023 Mar 11;14(3):194

HnRNPAB is an independent prognostic factor in non‑small cell lung cancer and is involved in cell proliferation and metastasis.

Wang Q, Gou X, Liu L, Zhang T, Yuan H, Zhao Y, Xie Y, Zhou J, Song K
Oncology letters 2023 Jun;25(6):215

The role of TOP2A in immunotherapy and vasculogenic mimicry in non-small cell lung cancer and its potential mechanism.

Wu J, Zhang L, Li W, Wang L, Jia Q, Shi F, Li K, Liao L, Shi Y, Wu S
Scientific reports 2023 Jul 5;13(1):10906

SPARC expression in tumor microenvironment induces partial epithelial-to-mesenchymal transition of esophageal adenocarcinoma cells via cooperating with TGF-β signaling.

Ma W, Yan Y, Bai S, Zhou Y, Wang X, Feng Z, Li G, Zhou S, Zhang J, Ren J
Cell biology international 2023 Jan;47(1):250-259

Formin protein DIAPH1 positively regulates PD-L1 expression and predicts the therapeutic response to anti-PD-1/PD-L1 immunotherapy.

Mei J, Cai Y, Wang H, Xu R, Zhou J, Lu J, Yang X, Pan J, Liu C, Xu J, Zhu Y
Clinical immunology (Orlando, Fla.) 2023 Jan;246:109204

LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.

Chen QW, Cai QQ, Yang Y, Dong S, Liu YY, Chen ZY, Kang CL, Qi B, Dong YW, Wu W, Zhuang LP, Shen YH, Meng ZQ, Wu XZ
Clinical and translational medicine 2023 Jan;13(1):e1129

HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.

Zhang Y, Ding P, Wang Y, Shao C, Guo K, Yang H, Feng Y, Ning J, Pan M, Wang P, Yan X, Ma Z, Han J
Cell death & disease 2023 Jan 18;14(1):38

LINC01608 activated by YY1 facilitate hepatocellular carcinoma progression by modulating the EGFR/ERK axis.

Han M, Liu F, Li X, Zhang H, Pan Y, Liu Y, Zhu H, Liang H, Chen X, Liao Z, Zhang Z, Zhang B
Liver international : official journal of the International Association for the Study of the Liver 2023 Feb;43(2):471-489

ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.

Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335

α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape.

Kang G, Jiao Y, Pan P, Fan H, Li Q, Li X, Li J, Wang Y, Jia Y, Wang J, Sun H, Ma X
Carcinogenesis 2023 Dec 15;44(10-11):773-784

The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA.

Hou YR, Diao LT, Hu YX, Zhang QQ, Lv G, Tao S, Xu WY, Xie SJ, Zhang Q, Xiao ZD
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(23):e2301983

A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis.

Kasamatsu H, Chino T, Hasegawa T, Utsunomiya N, Utsunomiya A, Yamada M, Oyama N, Hasegawa M
Arthritis research & therapy 2023 Aug 25;25(1):156

Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma.

Wu Y, Duan Y, Han W, Cao J, Ye B, Chen P, Li H, Wang Y, Liu J, Fang Y, Yue K, Wu Y, Wang X, Jing C
Cell death & disease 2023 Aug 12;14(8):517

Downregulation of MUS81 expression inhibits cell migration and maintains EBV latent infection through miR-BART9-5p in EBV-associated gastric cancer.

Zhang Y, Shi D, Zhang X, Wu S, Liu W, Luo B
Journal of medical virology 2023 Apr;95(4):e28725

Nuclear respiratory factor 1 promotes the progression of EBV-associated gastric cancer and maintains EBV latent infection.

Liang Y, Liu W, Zhao M, Shi D, Zhang Y, Luo B
Virus genes 2023 Apr;59(2):204-214

Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1.

Fang T, Jiao Z, You Y, Cao J, Wang C, Liu J, Zhao W
Biochemical pharmacology 2023 Apr;210:115489

Micro ribonucleic acid-448 regulates zinc finger e-box binding homeobox 1 to inhibit the growth of breast cancer cells and increase their sensitivity to chemotherapy.

Zhou Y, Sun L, Zhang Y, Chen K
Clinics (Sao Paulo, Brazil) 2022;77:100089

JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells.

Liu LH, Fang CK, Ge FC, Wang JN, Zhang XB, Luo R, Zhang Y, Feng KL, Qiu ZW, Zhong C
Journal of oncology 2022;2022:7823433

Biochanin A Suppresses Tumor Progression and PD-L1 Expression via Inhibiting ZEB1 Expression in Colorectal Cancer.

Xu J, Yang X, Pan J, Fan H, Mei J, Hua D
Journal of oncology 2022;2022:3224373

NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling.

Huang Q, Xu J, Ge Y, Shi Y, Wang F, Zhu M
Open life sciences 2022;17(1):447-454

Protein-protein interactions between RUNX3 and ZEB1 in chronic lung injury induced by methamphetamine abuse.

Bao N, Cheng L, Wang Y, Peng Z, Wang Z, Chen S
Frontiers in pharmacology 2022;13:1025922

ATP11A promotes EMT by regulating Numb PRR(L) in pancreatic cancer cells.

Chen L, Tang J, Sheng W, Sun J, Ma Y, Dong M
PeerJ 2022;10:e13172

Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathway.

Liang Z, Liu L, Gao R, Che C, Yang G
Cellular & molecular biology letters 2022 Oct 9;27(1):88

CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.

Si M, Song Y, Wang X, Wang D, Liu X, Qu X, Song Z, Yu X
Cell & bioscience 2022 Oct 9;12(1):171

IGF2BP2 Promotes Epithelial to Mesenchymal Transition and Metastasis through Stabilizing HMGA1 mRNA in Gastric Cancer.

Ouyang J, Li J, Li D, Jiang J, Hao T, Xia Y, Lu X, Zhang C, He Y
Cancers 2022 Oct 31;14(21)

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Sun M, Zhang X, Bi F, Wang D, Zhou X, Li X, Yang Q
Cancers 2022 Oct 25;14(21)

KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.

Li T, Zhai D, Zhang M, Ye R, Kuang X, Shao N, Bi J, Lin Y
Cancer letters 2022 Nov 1;548:215904

Use of High-Plex Data Reveals Novel Insights into the Tumour Microenvironment of Clear Cell Renal Cell Carcinoma.

De Filippis R, Wölflein G, Um IH, Caie PD, Warren S, White A, Suen E, To E, Arandjelović O, Harrison DJ
Cancers 2022 Nov 1;14(21)

Single-Cell RNA-seq Reveals a Developmental Hierarchy Super-Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer.

Ge G, Han Y, Zhang J, Li X, Liu X, Gong Y, Lei Z, Wang J, Zhu W, Xu Y, Peng Y, Deng J, Zhang B, Li X, Zhou L, He H, Ci W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(15):e2105530

Exosomal MMP-1 transfers metastasis potential in triple-negative breast cancer through PAR1-mediated EMT.

Zhu Y, Tao Z, Chen Y, Lin S, Zhu M, Ji W, Liu X, Li T, Hu X
Breast cancer research and treatment 2022 May;193(1):65-81

α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer.

Zhang Q, Jia Y, Pan P, Zhang X, Jia Y, Zhu P, Chen X, Jiao Y, Kang G, Zhang L, Ma X
Carcinogenesis 2022 May 19;43(4):393-404

Mechanism of LncRNA XIST/ miR-101-3p/ZEB1 axis in EMT associated with silicosis.

Li C, Xia J, Yao W, Yang G, Tian Y, Qi Y, Hao C
Toxicology letters 2022 May 1;360:11-19

Identification of the hub genes and transcription factor-miRNA axes involved in Helicobacter pylori-associated gastric cancer.

Zhao P, Ma X, Cheng J, Chen H, Li L
Oncology letters 2022 Mar;23(3):89

The cancer/testis antigen HORMAD1 mediates epithelial-mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer.

Liu K, Cheng L, Zhu K, Wang J, Shu Q
Cell death discovery 2022 Mar 28;8(1):136

Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.

Zhu M, Niu J, Jiang J, Dong T, Chen Y, Yang X, Liu P
Life sciences 2022 Mar 15;293:120358

HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.

Guo K, Ma Z, Zhang Y, Han L, Shao C, Feng Y, Gao F, Di S, Zhang Z, Zhang J, Tabbò F, Ekman S, Suda K, Cappuzzo F, Han J, Li X, Yan X
Journal of experimental & clinical cancer research : CR 2022 Mar 11;41(1):91

The ETS1-LINC00278 negative feedback loop plays a role in COL4A1/COL4A2 regulation in laryngeal squamous cell carcinoma.

Yang C, Cao H, Yang JW, Wang JT, Yu MM, Wang BS
Neoplasma 2022 Jul;69(4):841-858

The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion.

Zhu P, Kang G, Jiao Y, Gui C, Fan H, Li X, Jia Y, Zhang L, Ma X
Human cell 2022 Jul;35(4):1207-1218

Autophagy deficiency promotes lung metastasis of prostate cancer via stabilization of TWIST1.

Shi YX, Sun ZW, Jia DL, Wang HB
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Jul;24(7):1403-1412

YTHDF3 facilitates triple-negative breast cancer progression and metastasis by stabilizing ZEB1 mRNA in an m(6)A-dependent manner.

Lin Y, Jin X, Nie Q, Chen M, Guo W, Chen L, Li Y, Chen X, Zhang W, Chen H, Jiang M, Xiao H, Zhang J, Fu F, Wang C
Annals of translational medicine 2022 Jan;10(2):83

ZC3H15 promotes glioblastoma progression through regulating EGFR stability.

Hou J, Xu M, Gu H, Pei D, Liu Y, Huang P, Chang H, Cui H
Cell death & disease 2022 Jan 13;13(1):55

CTCF Expression and Dynamic Motif Accessibility Modulates Epithelial-Mesenchymal Gene Expression.

Johnson KS, Hussein S, Chakraborty P, Muruganantham A, Mikhail S, Gonzalez G, Song S, Jolly MK, Toneff MJ, Benton ML, Lin YC, Taube JH
Cancers 2022 Jan 1;14(1)

SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.

Cui X, Wang Y, Lan W, Wang S, Cui Y, Zhang X, Lin Z, Piao J
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84

FGD3 binds with HSF4 to suppress p65 expression and inhibit pancreatic cancer progression.

Guo F, Cheng X, Jing B, Wu H, Jin X
Oncogene 2022 Feb;41(6):838-851

The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.

Li M, Rao X, Cui Y, Zhang L, Li X, Wang B, Zheng Y, Teng L, Zhou T, Zhuo W
Oncogene 2022 Feb;41(6):770-781

Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer.

Sheng W, Tang J, Cao R, Shi X, Ma Y, Dong M
Cell death & disease 2022 Feb 23;13(2):173

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.

Chen H, Yu Y, Yang M, Huang H, Ma S, Hu J, Xi Z, Guo H, Yao G, Yang L, Huang X, Zhang F, Tan G, Wu H, Zheng W, Li L
Cell & bioscience 2022 Feb 23;12(1):19

FERMT1 contributes to the migration and invasion of nasopharyngeal carcinoma through epithelial-mesenchymal transition and cell cycle arrest.

Li L, Li P, Zhang W, Zhou H, Guo E, Hu G, Zhang L
Cancer cell international 2022 Feb 10;22(1):70

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.

Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138

Molecular mechanism of aquaporin 3 (AQP3) regulating by LMP2A and its crosstalk with 4E-BP1 via ERK signaling pathway in EBV-associated gastric cancer.

Yu C, Zhang X, Wang J, Song H, Liu W, Luo B
Virus research 2022 Dec;322:198947

CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway.

Li H, Xue S, Zhang X, Li F, Bei S, Feng L
Regenerative therapy 2022 Dec;21:25-33

Jianpi Huayu decoction inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing exosomal miR-23a-3p/Smad signaling.

Xie CF, Feng KL, Wang JN, Luo R, Fang CK, Zhang Y, Shen CP, Zhong C
Journal of ethnopharmacology 2022 Aug 10;294:115360

EML4-ALK G1202R mutation induces EMT and confers resistance to ceritinib in NSCLC cells via activation of STAT3/Slug signaling.

Shen J, Meng Y, Wang K, Gao M, Du J, Wang J, Li Z, Zuo D, Wu Y
Cellular signalling 2022 Apr;92:110264

Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis.

Mohammadi Ghahhari N, Sznurkowska MK, Hulo N, Bernasconi L, Aceto N, Picard D
Nature communications 2022 Apr 19;13(1):2104

LncRNA UCA1 regulates silicosis-related lung epithelial cell-to-mesenchymal transition through competitive adsorption of miR-204-5p.

Yang G, Tian Y, Li C, Xia J, Qi Y, Yao W, Hao C
Toxicology and applied pharmacology 2022 Apr 15;441:115977

Epithelial-Mesenchymal Transition Induces GSDME Transcriptional Activation for Inflammatory Pyroptosis.

Jia C, Zhang Z, Tang J, Cai MC, Zang J, Shi K, Sun Y, Wu J, Shi H, Shi W, Ma P, Zhao X, Yu Z, Fu Y, Zhuang G
Frontiers in cell and developmental biology 2021;9:781365

ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/β-Catenin Signaling.

Xu C, Shi H, Jiang X, Fan Y, Huang D, Qi X, Cheng Q
Frontiers in molecular biosciences 2021;8:682728

ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.

Li Y, Sun C, Tan Y, Zhang H, Li Y, Zou H
International journal of biological sciences 2021;17(2):635-650

miR-944 Suppresses EGF-Induced EMT in Colorectal Cancer Cells by Directly Targeting GATA6.

Tang J, Gao W, Liu G, Sheng W, Zhou J, Dong Q, Dong M
OncoTargets and therapy 2021;14:2311-2325

Normal Basal Epithelial Cells Stimulate the Migration and Invasion of Prostate Cancer Cell RM-1 by TGF-β1/STAT3 Axis in vitro.

Li CY, Chen CY, An JH, Wu JB, Shen H
Cancer management and research 2021;13:3685-3697

Dihydromyricetin Inhibits Tumor Growth and Epithelial-Mesenchymal Transition through regulating miR-455-3p in Cholangiocarcinoma.

Li X, Yang ZS, Cai WW, Deng Y, Chen L, Tan SL
Journal of Cancer 2021;12(20):6058-6070

Inhibitory Effect of Dihydroartemisinin on the Proliferation and Migration of Melanoma Cells and Experimental Lung Metastasis From Melanoma in Mice.

Zhang Q, Jin L, Jin Q, Wei Q, Sun M, Yue Q, Liu H, Li F, Li H, Ren X, Jin G
Frontiers in pharmacology 2021;12:727275

TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer.

Yang M, Huang Q, Li C, Jiang Z, Sun J, Wang Z, Liang R, Li D, Li B, Zhao H
Frontiers in immunology 2021;12:647540

XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression.

Yang WQ, Zhao WJ, Zhu LL, Xu SJ, Zhang XL, Liang Y, Ding XF, Kiselyov A, Chen G
Frontiers in pharmacology 2021;12:603453

N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.

Chen C, Yuan W, Zhou Q, Shao B, Guo Y, Wang W, Yang S, Guo Y, Zhao L, Dang Q, Yang X, Wang G, Kang Q, Ji Z, Liu J, Sun Z
Theranostics 2021;11(9):4298-4315

Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription.

Chen Z, Xiang L, Hu Z, Ou H, Liu X, Yu L, Chen W, Jiang L, Yu Q, Fang Y, Xu Y, Liu Q, Huang Y, Li X, Yang D
American journal of cancer research 2021;11(1):277-296

A Novel Ferroptosis-Related 4-Gene Prognostic Signature for Cholangiocarcinoma and Photodynamic Therapy.

Zhang ZJ, Huang YP, Li XX, Liu ZT, Liu K, Deng XF, Xiong L, Zou H, Wen Y
Frontiers in oncology 2021;11:747445

TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.

Li R, Zhu L, Peng Y, Zhang X, Dai C, Liu D
Frontiers in oncology 2021;11:695740

Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63.

Liu Y, Zhang P, Wu Q, Fang H, Wang Y, Xiao Y, Cong M, Wang T, He Y, Ma C, Tian P, Liang Y, Qin LX, Yang Q, Yang Q, Liao L, Hu G
Nature communications 2021 Sep 2;12(1):5232

Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway.

Nong S, Wei Z, Wang Z, Ma L, Guan Y, Ni J
Stem cells and development 2021 Sep 15;30(18):934-945

TRIM16 overexpression inhibits the metastasis of colorectal cancer through mediating Snail degradation.

Ruan L, Liu W, Yang Y, Chu Z, Yang C, Yang T, Sun J
Experimental cell research 2021 Sep 1;406(1):112735

Transcription factor POU4F2 promotes colorectal cancer cell migration and invasion through hedgehog-mediated epithelial-mesenchymal transition.

Guo K, Wang P, Zhang L, Zhou Y, Dai X, Yan Y, Chen Y, Wasan HS, Yu J, Ruan S, Sun L
Cancer science 2021 Oct;112(10):4176-4186

ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β.

Meng L, Zheng Y, Liu S, Ju Y, Ren S, Sang Y, Zhu Y, Gu L, Liu F, Zhao Y, Zhang X, Sang M
Cancer letters 2021 Oct 28;519:117-129

Phenolic Compounds from Mori Cortex Ameliorate Sodium Oleate-Induced Epithelial-Mesenchymal Transition and Fibrosis in NRK-52e Cells through CD36.

Ruan Y, Yuan PP, Wei YX, Zhang Q, Gao LY, Li PY, Chen Y, Fu Y, Cao YG, Zheng XK, Feng WS
Molecules (Basel, Switzerland) 2021 Oct 11;26(20)

Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.

Liu S, Gu L, Wu N, Song J, Yan J, Yang S, Feng Y, Wang Z, Wang L, Zhang Y, Jin Y
Cell death & disease 2021 Oct 11;12(10):929

Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway.

Wang D, Cui L, Yang Q, Wang J
Cellular signalling 2021 Nov;87:110145

Silencing ACTG1 Expression Induces Prostate Cancer Epithelial Mesenchymal Transition Through MAPK/ERK Signaling Pathway.

Xiao L, Peng H, Yan M, Chen S
DNA and cell biology 2021 Nov;40(11):1445-1455

MiR-BART2-3p targets Unc-51-like kinase 1 and inhibits cell autophagy and migration in Epstein-Barr virus-associated gastric cancer.

Shi D, Zhang Y, Mao T, Liu D, Liu W, Luo B
Virus research 2021 Nov;305:198567

The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.

Chen YD, Cai FY, Mao YZ, Yang YS, Xu K, Liu XF, Fan WW, Chen W, Jiang FQ, Zhang H
Chinese journal of natural medicines 2021 Nov;19(11):815-824

Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing.

Qu H, Miao T, Wang Y, Tan L, Huang B, Zhang L, Liu X, Long M, Zhang R, Liao X, Gong X, Wang J, Xiong X, Liu J, Li X, Yu J, Yang G, Zhu Z, Zheng H, Zheng Y
Diabetes 2021 May;70(5):1170-1184

Methylation gene KCNC1 is associated with overall survival in patients with seminoma.

Chen S, Xiao L, Peng H, Wang Z, Xie J
Oncology reports 2021 May;45(5)

Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes.

Riechert E, Kmietczyk V, Stein F, Schwarzl T, Sekaran T, Jürgensen L, Kamuf-Schenk V, Varma E, Hofmann C, Rettel M, Gür K, Ölschläger J, Kühl F, Martin J, Ramirez-Pedraza M, Fernandez M, Doroudgar S, Méndez R, Katus HA, Hentze MW, Völkers M
Cell reports 2021 May 11;35(6):109100

Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.

Ling B, Wei P, Xiao J, Cen B, Wei H, Feng X, Ye G, Li S, Zhang Z, Liang W, Huang S, Huang W
Oncology reports 2021 Mar;45(3):1044-1058

Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis.

Yu Z, Zhu X, Li Y, Liang M, Liu M, Liu Z, Qin L, Wu X, Du K, Liu L, Wang Y, Zheng Y
Cell death & disease 2021 Mar 24;12(4):313

MicroRNA‑485‑5p suppresses the progression of esophageal squamous cell carcinoma by targeting flotillin‑1 and inhibits the epithelial‑mesenchymal transition.

Zhao R, Shan Y, Zhou X, Zhang C, Zhao R, Zhao L, Shan B
Oncology reports 2021 Jun;45(6)

Squamous cell carcinoma subverts adjacent histologically normal epithelium to promote lateral invasion.

Singh P, Banerjee R, Piao S, Costa de Medeiros M, Bellile E, Liu M, Damodaran Puthiya Veettil D, Schmitd LB, Russo N, Danella E, Inglehart RC, Pineault KM, Wellik DM, Wolf G, D'Silva NJ
The Journal of experimental medicine 2021 Jun 7;218(6)

Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea.

Billings SE, Myers NM, Quiruz L, Cheng AG
Development (Cambridge, England) 2021 Jun 1;148(11)

YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.

Liu X, Chen D, Chen H, Wang W, Liu Y, Wang Y, Duan C, Ning Z, Guo X, Otkur W, Liu J, Qi H, Liu X, Lin A, Xia T, Liu HX, Piao HL
Cancer communications (London, England) 2021 Jul;41(7):576-595

Krüppel-like factor 5-induced overexpression of long non-coding RNA DANCR promotes the progression of cervical cancer via repressing microRNA-145-3p to target ZEB1.

Hu C, Han Y, Zhu G, Li G, Wu X
Cell cycle (Georgetown, Tex.) 2021 Jul;20(14):1441-1454

Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.

Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D
Oncology reports 2021 Jan;45(1):139-150

Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.

Bin J, Nie S, Tang Z, Kang A, Fu Z, Hu Y, Liao Q, Xiong W, Zhou Y, Tang Y, Jiang J
Journal of cellular physiology 2021 Jan;236(1):523-535

Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease.

Xian S, Chen A, Wu X, Lu C, Wu Y, Huang F, Zeng Z
Molecular medicine reports 2021 Jan;23(1)

Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53.

Wang J, Liu D, Sun Z, Ye T, Li J, Zeng B, Zhao Q, Rosie Xing H
Cell death & disease 2021 Jan 19;12(1):98

The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.

Xiang T, Yuan C, Guo X, Wang H, Cai Q, Xiang Y, Luo W, Liu G
Cell death & disease 2021 Feb 4;12(2):150

Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression.

Yang F, Yuan WQ, Li J, Luo YQ
Oncology letters 2021 Dec;22(6):847

SETD8 induces stemness and epithelial-mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression.

Liu M, Shi Y, Hu Q, Qin Y, Ji S, Liu W, Zhuo Q, Fan G, Ye Z, Song C, Yu X, Xu X, Xu W
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1614-1624

Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway.

Zhao Z, Chu W, Zheng Y, Wang C, Yang Y, Xu T, Yang X, Zhang W, Ding X, Li G, Zhang H, Zhou J, Ye J, Wu H, Song X, Wu Y
Cell communication and signaling : CCS 2021 Dec 18;19(1):121

ZEB1 Induces Ddr1 Promoter Hypermethylation and Contributes to the Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment.

Chen YY, Jiang KS, Bai XH, Liu M, Lin SY, Xu T, Wei JY, Li D, Xiong YC, Xin WJ, Li ZY
Neurochemical research 2021 Aug;46(8):2181-2191

Chromium (VI) promotes EMT by regulating FLNA in BLCA.

Sheng F, Chen KX, Liu J, Li JX, Liang GH, Xu Y, Du E, Zhang ZH
Environmental toxicology 2021 Aug;36(8):1694-1701

Identification of a mesenchymal-related signature associated with clinical prognosis in glioma.

Zhang Z, Chen J, Huo X, Zong G, Huang K, Cheng M, Sun L, Yue X, Bian E, Zhao B
Aging 2021 Apr 19;13(9):12431-12455

Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer.

Gudi RR, Janakiraman H, Howe PH, Palanisamy V, Vasu C
Oncotarget 2021 Apr 13;12(8):807-822

GRHL2 Acts as an Anti-Oncogene in Bladder Cancer by Regulating ZEB1 in Epithelial-Mesenchymal Transition (EMT) Process.

Shen J, Lv X, Zhang L
OncoTargets and therapy 2020;13:2511-2522

GALC Triggers Tumorigenicity of Colorectal Cancer via Senescent Fibroblasts.

Yang M, Jiang Z, Yao G, Wang Z, Sun J, Qin H, Zhao H
Frontiers in oncology 2020;10:380

Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway.

Yang M, Wang A, Li C, Sun J, Yi G, Cheng H, Liu X, Wang Z, Zhou Y, Yao G, Wang S, Liang R, Li B, Li D, Zhao H
Frontiers in oncology 2020;10:1141

Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.

Zhou L, Sheng W, Jia C, Shi X, Cao R, Wang G, Lin Y, Zhu F, Dong Q, Dong M
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572

The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.

Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438

Calreticulin promotes EMT in pancreatic cancer via mediating Ca(2+) dependent acute and chronic endoplasmic reticulum stress.

Sheng W, Wang G, Tang J, Shi X, Cao R, Sun J, Lin YH, Jia C, Chen C, Zhou J, Dong M
Journal of experimental & clinical cancer research : CR 2020 Oct 7;39(1):209

Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.

Chen Y, Niu J, Li L, Li Z, Jiang J, Zhu M, Dong T, Zhang J, Shi C, Xu P, Lu Y, Jiang Y, Liu P, Chen W
Life sciences 2020 Oct 1;258:118158

Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1.

Xiang L, Huang X, Wang S, Ou H, Chen Z, Hu Z, Huang Y, Li X, Yuan Y, Yang D
Cancer science 2020 Nov;111(11):4102-4117

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.

Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)

Babao Dan inhibits the migration and invasion of gastric cancer cells by suppressing epithelial-mesenchymal transition through the TGF-β/Smad pathway.

Liu J, Chen Y, Cao Z, Guan B, Peng J, Chen Y, Zhan Z, Sferra TJ, Sankararaman S, Lin J
The Journal of international medical research 2020 Jun;48(6):300060520925598

Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.

Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D
International journal of oncology 2020 Jul;57(1):183-196

PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.

Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235

CircATRNL1 promotes epithelial-mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro.

Wang D, Luo Y, Wang G, Yang Q
Cell death & disease 2020 Jul 29;11(7):594

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.

Sheng W, Shi X, Lin Y, Tang J, Jia C, Cao R, Sun J, Wang G, Zhou L, Dong M
Journal of experimental & clinical cancer research : CR 2020 Jan 17;39(1):16

A super-enhancer controls TGF- β signaling in pancreatic cancer through downregulation of TGFBR2.

Zhu X, Zhang T, Zhang Y, Chen H, Shen J, Jin X, Wei J, Zhang E, Xiao M, Fan Y, Mao R, Zhou G
Cellular signalling 2020 Feb;66:109470

Effect of CUL4A on the metastatic potential of lung adenocarcinoma to the bone.

Cao PP, Chen WJ, Pang HL, Shen WW, Xue P, Duan L, Xu YX, Liu LL, Zhang HL
Oncology reports 2020 Feb;43(2):662-670

PLAGL2 promotes epithelial-mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1.

Wu L, Zhou Z, Han S, Chen J, Liu Z, Zhang X, Yuan W, Ji J, Shu X
British journal of cancer 2020 Feb;122(4):578-589

SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.

Xu M, Zhang X, Zhang S, Piao J, Yang Y, Wang X, Lin Z
Aging 2020 Dec 3;13(1):1032-1050

Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail.

Yuan F, Miao Z, Chen W, Wu F, Wei C, Yong J, Xiao C
Journal of biochemistry 2020 Dec 26;168(6):651-657

Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1.

Zhou F, Du C, Xu D, Lu J, Zhou L, Wu C, Wu B, Huang J
Molecular medicine reports 2020 Aug;22(2):1382-1390

Fangjihuangqi Decoction inhibits MDA-MB-231 cell invasion in vitro and decreases tumor growth and metastasis in triple-negative breast cancer xenografts tumor zebrafish model.

Guo Y, Fan Y, Pei X
Cancer medicine 2020 Apr;9(7):2564-2578

LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.

Ma T, Liang Y, Li Y, Song X, Zhang N, Li X, Chen B, Zhao W, Wang L, Yang Q
Cellular signalling 2020 Apr;68:109536

RIOK2 is negatively regulated by miR-4744 and promotes glioma cell migration/invasion through epithelial-mesenchymal transition.

Song Y, Li C, Jin L, Xing J, Sha Z, Zhang T, Ji D, Yu R, Gao S
Journal of cellular and molecular medicine 2020 Apr;24(8):4494-4509

Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.

Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473

MTF2 Induces Epithelial-Mesenchymal Transition and Progression of Hepatocellular Carcinoma by Transcriptionally Activating Snail.

Wu TT, Cai J, Tian YH, Chen JF, Cheng ZL, Pu CS, Shi WZ, Suo XP, Wu XJ, Dou XW, Zhang KM
OncoTargets and therapy 2019;12:11207-11220

KIAA0101 is a novel transcriptional target of FoxM1 and is involved in the regulation of hepatocellular carcinoma microvascular invasion by regulating epithelial-mesenchymal transition.

Zhang T, Guo J, Gu J, Chen K, Wang Z, Li H, Wang G, Wang J
Journal of Cancer 2019;10(15):3501-3516

Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma.

Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, Gu Y, Sun H, Liang P
Cell death & disease 2019 Sep 26;10(10):717

Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex.

Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W, Gao WQ
Cell death and differentiation 2019 Nov;26(11):2479-2492

α-Aminoisobutyric Acid-Containing Amphipathic Helical Peptide-Cyclic RGD Conjugation as a Potential Drug Delivery System for MicroRNA Replacement Therapy in Vitro.

Taniguchi K, Wada SI, Ito Y, Hayashi J, Inomata Y, Lee SW, Tanaka T, Komura K, Akao Y, Urata H, Uchiyama K
Molecular pharmaceutics 2019 Nov 4;16(11):4542-4550

MiR-200a ameliorates peritoneal fibrosis and functional deterioration in a rat model of peritoneal dialysis.

Wei X, Bao Y, Zhan X, Zhang L, Hao G, Zhou J, Chen Q
International urology and nephrology 2019 May;51(5):889-896

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.

Wu W, He K, Guo Q, Chen J, Zhang M, Huang K, Yang D, Wu L, Deng Y, Luo X, Yu H, Ding Q, Xiang G
Journal of cellular and molecular medicine 2019 May;23(5):3118-3129

Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.

Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139

circ-CSPP1 promotes proliferation, invasion and migration of ovarian cancer cells by acting as a miR-1236-3p sponge.

Li QH, Liu Y, Chen S, Zong ZH, Du YP, Sheng XJ, Zhao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jun;114:108832

Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.

Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M
Neoplasia (New York, N.Y.) 2019 Jul;21(7):627-640

Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer.

Yuan W, Ji J, Shu Y, Chen J, Liu S, Wu L, Zhou Z, Liu Z, Tang Q, Zhang X, Shu X
Journal of molecular medicine (Berlin, Germany) 2019 Jan;97(1):89-102

Long non‑coding RNA ENST00000547547 inhibits cell proliferation, invasion and migration in colorectal cancer cells.

Ai X, Lei Q, Shen X, Li J, Cen C, Xie G, Luo B, Zhu W, Hu G, Wu H, Chen M, Li X, Lin C
Oncology reports 2019 Jan;41(1):483-491

LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition.

Li J, Hao Y, Mao W, Xue X, Xu P, Liu L, Yuan J, Zhang D, Li N, Chen H, Zhao L, Sun Z, Luo J, Chen R, Zhao RC
Journal of hematology & oncology 2019 Feb 22;12(1):19

Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma.

Peng L, Jiang B, Yuan X, Qiu Y, Peng J, Huang Y, Zhang C, Zhang Y, Lin Z, Li J, Yao W, Deng W, Zhang Y, Meng M, Pan X, Li C, Yin D, Bi X, Li G, Lin DC
Cancer research 2019 Feb 1;79(3):572-584

miR-194 suppresses epithelial-mesenchymal transition of retinal pigment epithelial cells by directly targeting ZEB1.

Cui L, Lyu Y, Jin X, Wang Y, Li X, Wang J, Zhang J, Deng Z, Yang N, Zheng Z, Guo Y, Wang C, Mao R, Xu J, Gao F, Jin C, Zhang J, Tian H, Xu GT, Lu L
Annals of translational medicine 2019 Dec;7(23):751

Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.

Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation.

Senigl F, Maman Y, Dinesh RK, Alinikula J, Seth RB, Pecnova L, Omer AD, Rao SSP, Weisz D, Buerstedde JM, Aiden EL, Casellas R, Hejnar J, Schatz DG
Cell reports 2019 Dec 17;29(12):3902-3915.e8

CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer.

Yu S, Zhang Y, Li Q, Zhang Z, Zhao G, Xu J
Cell death & disease 2019 Dec 11;10(12):949

Silencing TTK expression inhibits the proliferation and progression of prostate cancer.

Chen S, Wang J, Wang L, Peng H, Xiao L, Li C, Lin D, Yang K
Experimental cell research 2019 Dec 1;385(1):111669

miR-194 regulates the proliferation and migration via targeting Hnf1β in mouse metanephric mesenchyme cells.

Liu Y, Hu Y, Ni D, Liu J, Xia H, Xu L, Zhou Q, Xie Y
In vitro cellular & developmental biology. Animal 2019 Aug;55(7):512-521

MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis.

Cheng X, Xu S, Pan J, Zheng J, Wang X, Yu H, Bao J, Xu Y, Guan H, Zhang L
Journal of cell science 2019 Aug 22;132(16)

Inhibition of formin like 2 promotes the transition of ectopic endometrial stromal cells to epithelial cells in adenomyosis through a MET-like process.

Li Y, Zhang Q, Liu F, Zhang Z, Zou Y, Yang B, Luo Y, Wang L, Huang O
Gene 2019 Aug 20;710:186-192

miR-26a/HOXC9 Dysregulation Promotes Metastasis and Stem Cell-Like Phenotype of Gastric Cancer.

Peng X, Kang Q, Wan R, Wang Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(4):1659-1676

LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1.

Liang C, Yang Y, Guan J, Lv T, Qu S, Fu Q, Zhao H
Pathology, research and practice 2018 Sep;214(9):1474-1481

SNORA42 enhances prostate cancer cell viability, migration and EMT and is correlated with prostate cancer poor prognosis.

Yi C, Wan X, Zhang Y, Fu F, Zhao C, Qin R, Wu H, Li Y, Huang Y
The international journal of biochemistry & cell biology 2018 Sep;102:138-150

YAP drives cutaneous squamous cell carcinoma formation and progression.

Vincent-Mistiaen Z, Elbediwy A, Vanyai H, Cotton J, Stamp G, Nye E, Spencer-Dene B, Thomas GJ, Mao J, Thompson B
eLife 2018 Sep 20;7

The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo.

Huang C, Huang S, Li H, Li X, Li B, Zhong L, Wang J, Zou M, He X, Zheng H, Si X, Liao W, Liao Y, Yang L, Bin J
Journal of experimental & clinical cancer research : CR 2018 Sep 19;37(1):232

Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.

Xu WY, Hu QS, Qin Y, Zhang B, Liu WS, Ni QX, Xu J, Yu XJ
World journal of gastroenterology 2018 Nov 21;24(43):4893-4905

MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

Li J, Zou K, Yu L, Zhao W, Lu Y, Mao J, Wang B, Wang L, Fan S, Song B, Li L
Molecular therapy. Nucleic acids 2018 Mar 2;10:426-437

ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.

Wang J, Zhang Z, Li R, Mao F, Sun W, Chen J, Zhang H, Bartsch JW, Shu K, Lei T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1066-1077

ZEB1 stimulates breast cancer growth by up-regulating hTERT expression.

Yu P, Shen X, Yang W, Zhang Y, Liu C, Huang T
Biochemical and biophysical research communications 2018 Jan 22;495(4):2505-2511

PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.

Zhao B, Liu L, Mao J, Zhang Z, Wang Q, Li Q
Cell death & disease 2018 Feb 22;9(3):307

Myostatin promotes the epithelial-to-mesenchymal transition of the dermomyotome during somitogenesis.

Zhou Y, Zhang Y, Zhu D
Developmental dynamics : an official publication of the American Association of Anatomists 2018 Dec;247(12):1241-1252

A cell culture condition that induces the mesenchymal-epithelial transition of dedifferentiated porcine retinal pigment epithelial cells.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ZEB1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ZEB1. This antibody recognizes human,mouse,rat antigen. The ZEB1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 21544-1-AP.pdf

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