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- References [147]
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- Product number
- 11570-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11570-1-AP, RRID:AB_2247082
- Product name
- FUS/TLS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FUS/TLS antibody (Cat. #11570-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis.
Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2.
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15.
Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs.
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection.
Deletion of the Saccharomyces cerevisiae RACK1 homolog, ASC1, enhances autophagy which mitigates TDP-43 toxicity.
Rational Design of a Multivalent RNA Combining Structural Motifs Tailored to Multiple Domains of Fused in Sarcoma for Potent Inhibition of Aggregation.
Resolving the spatial and cellular architecture of intra-tumor heterogeneity by multi-region dissection of lung adenocarcinoma.
Deletion of the Saccharomyces cerevisiae RACK1 homolog, ASC1 , enhances autophagy which mitigates TDP-43 toxicity.
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules.
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors.
DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases.
The role of JPX in regulating FUS/SLC7A11 signaling pathway mediated ferroptosis in keloid fibroblasts and its potential in scar repair.
Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series.
Role of thrombus-derived exosomal lncRNA LOC101928697 in regulating endothelial function via FUS protein interaction in myocardial infarction.
M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development.
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
circLRCH3-FUS interaction stabilizes IFI35 mRNA, inhibiting autophagy and aggravating podocyte pyroptosis in lupus nephritis.
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.
CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.
Patterns of glucose hypometabolism can help differentiate FTLD-FET from other types of FTLD.
Reversal of cognitive deficits in FUS(R521G) amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation.
Localized synthesis of molecular chaperones sustains neuronal proteostasis.
Enhancing diabetic foot ulcer healing: Impact of the regulation of the FUS and ILF2 RNA‑binding proteins through negative pressure wound therapy.
Long non-coding RNA MALAT1 triggers ferroptosis via interaction with FUS to enhance ACSF2 mRNA stabilization in septic acute kidney injury.
Virus-modified paraspeckle-like condensates are hubs for viral RNA processing and their formation drives genomic instability.
The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD.
PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer.
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.
TAF15 amyloid filaments in frontotemporal lobar degeneration.
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress.
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Protein complexes from mouse and chick brain that interact with phospho-KXGS motif tau/microtubule associated protein antibody.
Neuropathologic findings in a patient with hemiparkinsonism and hemiatrophy syndrome.
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
The identification of high-performing antibodies for RNA-binding protein FUS for use in Western Blot, immunoprecipitation, and immunofluorescence.
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition.
Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis.
The lncRNA Neat1 is associated with astrocyte reactivity and memory deficits in a mouse model of Alzheimer's disease.
Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.
The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD.
Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies.
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation.
Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes.
HOTAIRM1 Maintained the Malignant Phenotype of tMSCs Transformed by GSCs via E2F7 by Binding to FUS.
Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.
FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy.
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease.
A toolkit for the identification of NEAT1_2/paraspeckle modulators.
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Proteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions.
Divergent transcriptional regulation of astrocyte reactivity across disorders.
LINC00313 facilitates osteosarcoma carcinogenesis and metastasis through enhancing EZH2 mRNA stability and EZH2-mediated silence of PTEN expression.
Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis.
Widespread Mislocalization of FUS Is Associated With Mitochondrial Abnormalities in Skeletal Muscle in Amyotrophic Lateral Sclerosis With FUS Mutations.
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.
LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.
A Deletion of the Nuclear Localization Signal Domain in the Fus Protein Induces Stable Post-stress Cytoplasmic Inclusions in SH-SY5Y Cells.
Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases.
Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization.
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.
An autopsy case report of neuronal intermediate filament inclusion disease presenting with predominantly upper motor neuron features.
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.
Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.
Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis.
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.
LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1.
Spinal Cord and Motor Neuron TDP-43 Pathology in a Sporadic Inclusion Body Myositis Patient.
Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models.
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection.
FUS contributes to mTOR-dependent inhibition of translation.
All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice.
Differential subcellular expression of (P525L)FUS as a putative biomarker for ALS phenoconversion.
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model.
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma.
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis.
LINC00473 mediates cyclin D1 expression through a balance between activation and repression signals in breast cancer cells.
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.
Two herpesviral noncoding PAN RNAs are functionally homologous but do not associate with common chromatin loci.
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.
Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases.
Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.
Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.
Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases.
Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer.
Functional domains of the FSHD-associated DUX4 protein.
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.
ALS-Related Mutant FUS Protein Is Mislocalized to Cytoplasm and Is Recruited into Stress Granules of Fibroblasts from Asymptomatic FUS P525L Mutation Carriers.
Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs.
Novel miR-b2122 regulates several ALS-related RNA-binding proteins.
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.
Molecular determinants of cytochrome C oxidase IV mRNA axonal trafficking.
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.
Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules.
Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis.
Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4.
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency.
Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.
ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation.
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.
Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells.
PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.
Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.
Atypical FTLD-FUS associated with ALS-TDP: a case report.
Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases.
Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.
Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain.
p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions.
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations.
Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.
Optineurin is colocalized with ubiquitin in Marinesco bodies.
Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase.
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.
Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
FUS pathology in basophilic inclusion body disease.
Zhou H, Ji Z, Sun H, Zhang W, Huang Y, Jin G, Cai H, Huang X, Dai J, Zhao J, Chen H, Fan S, Wu Y, Shen J
International journal of biological sciences 2026;22(1):346-364
International journal of biological sciences 2026;22(1):346-364
Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2.
Wang X, Li J, Jiang C, Zhang C, Yuan L, Zhang T, Liu Y, Ma S, Kang P, Li D, Guan X, Chen J, Jia W
Theranostics 2026;16(6):3032-3049
Theranostics 2026;16(6):3032-3049
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Guo L, Mann JR, Mauna JC, Copley KE, Wang H, Rubien JD, Bergmann CA, Carey JL, Merjane J, Ngo M, Xu J, Odeh HM, Lin J, Lee BL, Ganser L, Robinson E, Kim KM, Murthy AC, Paul T, Portz B, Gleixner AM, Diaz Z, Smirnov A, Padilla G, Lavorando E, Espy C, Shang Y, Huang EJ, Chesi A, Fawzi NL, Myong S, Donnelly CJ, Shorter J
Molecular cell 2026 Jan 8;86(1):114-134.e10
Molecular cell 2026 Jan 8;86(1):114-134.e10
Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15.
Tetter S, Varghese NR, Murzin AG, De Coster W, Van den Broeck M, Roeber S, Joseph JT, Newell K, Castellani R, Das S, Ang LC, Synofzik M, Herms J, Rademakers R, Ghetti B, Lashley T, Mackenzie IRA, Neumann M, Ryskeldi-Falcon B
bioRxiv : the preprint server for biology 2026 Jan 12;
bioRxiv : the preprint server for biology 2026 Jan 12;
Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs.
Cai Y, Zheng Z, Xu H, Zhu Y, Zepeda JC, Grueter BA, Wang X, Ku T, Duan Y, Tsang HWS, Fu WY, Fu AKY, Mellios N, Wong HH, Lai KO, Ip JPK
Science advances 2026 Feb 13;12(7):eads7509
Science advances 2026 Feb 13;12(7):eads7509
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.
De Coster W, Van den Broeck M, Baker M, Ghayal NB, Wynants S, Batzler A, Pottier C, Alidadiani S, Küçükali F, Jenkins GD, Policarpo R, van Blitterswijk M, DeJesus-Hernandez M, Soto-Beasley AI, Faura J, Coopman E, Hutten S, Mol MO, Wallon D, Sieben A, Finger EC, Murray ME, Forrest SL, Tartaglia MC, Troakes C, van Rooij JGJ, Nguyen AT, Reichard RR, Woodman NL, Nana AL, Weintraub S, Gefen T, De Vil B, Bodi I, Lopez OL, Boluda S, Belliard S, Lebert F, Marguet F, Mao Q, Mesulam MM, Boxer AL, Vandenbulcke M, Suh E, Schaeverbeke J, Lambert JC, Scholz SW, Dalgard CL, Traynor BJ, Gibbs RJ, Schellenberg GD, Dormann D, Joris G, De Pooter T, De Rijk P, D'Hert S, Van Dongen J, van der Zee J, Strazisar M, Gearing M, Kukar T, Flanagan M, Engelborghs S, Ghetti B, Newell KL, King A, Roeber S, Rosen HJ, Spina S, Cras P, Ertekin-Taner N, Wszolek ZK, Uitti RJ, Cheshire WP, Singer W, Herms J, Josephs KA, Whitwell JL, Petersen RC, Pasquier F, Nicolas G, Castellani R, Glass J, Miller BL, Kovacs GG, Rissman RA, Hiniker A, Deramecourt V, Ang LC, Lee-Way J, Van Deerlin VM, Dugger BN, Thal DR, Grinberg LT, Cruchaga C, Arzberger T, Munoz DG, Keith J, Zinman L, Rogaeva E, Lee EB, Haggarty SJ, Ansorge O, Husain M, Halliday GM, Al-Sarraj S, Ross OA, Sleegers K, Vandenberghe R, Boeve BF, Graff-Radford NR, Kofler J, White CL 3rd, Lashley T, Neumann M, Biernacka JM, Seeley WW, Seelaar H, van Swieten JC, Rohrer JD, Dickson DW, Mackenzie IRA, Rademakers R
Nature genetics 2026 Apr;58(4):726-736
Nature genetics 2026 Apr;58(4):726-736
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection.
Hodgson RE, Huang WP, Lang R, Kumar V, An H, Stender EGP, Chalakova ZP, Driver MD, Sanchez Avila A, Ellis BCS, Day E, Rayment JA, Baeg K, Strange A, Moll T, Wright GSA, van Vugt JJFA, Project MinE ALS Sequencing Consortium, Allen SP, Locker N, Pitout I, Fletcher S, Onck PR, Duss O, Cooper-Knock J, Shelkovnikova TA
Nature cell biology 2026 Apr;28(4):754-770
Nature cell biology 2026 Apr;28(4):754-770
Deletion of the Saccharomyces cerevisiae RACK1 homolog, ASC1, enhances autophagy which mitigates TDP-43 toxicity.
Park SK, Park S, Liebman SW
Genetics 2026 Apr 4;232(4)
Genetics 2026 Apr 4;232(4)
Rational Design of a Multivalent RNA Combining Structural Motifs Tailored to Multiple Domains of Fused in Sarcoma for Potent Inhibition of Aggregation.
Kuroiwa N, Sakaue F, Miura M, Go A, Iwase R, Iwata Hara R, Sanjo N, Ui-Tei K, Yokota T
Chembiochem : a European journal of chemical biology 2026 Apr 28;27(8):e202500568
Chembiochem : a European journal of chemical biology 2026 Apr 28;27(8):e202500568
Resolving the spatial and cellular architecture of intra-tumor heterogeneity by multi-region dissection of lung adenocarcinoma.
Mei S, Wang X, Zhao M, Huang Q, Huang Y, Su M, Zhang X, Wang X, Hao X, Wang T, Wu Y, Ma Y, Wang J, Zhang P, Zheng Y
Journal of genetics and genomics = Yi chuan xue bao 2025 Sep;52(9):1121-1132
Journal of genetics and genomics = Yi chuan xue bao 2025 Sep;52(9):1121-1132
Deletion of the Saccharomyces cerevisiae RACK1 homolog, ASC1 , enhances autophagy which mitigates TDP-43 toxicity.
Park SK, Park S, Liebman SW
bioRxiv : the preprint server for biology 2025 Sep 5;
bioRxiv : the preprint server for biology 2025 Sep 5;
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules.
Yap K, Chung TH, Hedges EC, Nishimura AL, Shaw CE, Makeyev EV
Nature communications 2025 Oct 20;16(1):9257
Nature communications 2025 Oct 20;16(1):9257
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
Resnick SJ, Qamar S, Krishna P, Korobeynikov V, Ausserwoger H, Miller A, Esposito P, Varela JA, Sheng J, Huang LH, Nixon-Abell J, Melore S, Chung CW, Läubli NF, Kapsiani S, Li X, Wang J, Zhang N, Alam MM, Burguete AS, Swayne TC, Chen Y, Liao YC, Shneider NA, Vendruscolo M, Knowles TPJ, Kaminski CF, Ruggeri FS, Kaminski Schierle GS, St George-Hyslop P, Chavez A
Nature communications 2025 Nov 21;16(1):10285
Nature communications 2025 Nov 21;16(1):10285
Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors.
Yang X, Li W, Yang S, Wang Z, Yin J, Zhang W, Tao H, Li S, Guo X, Dai Q, Zhu W, Li Y, Yan X, Luo C, Li J, Ren S, Wang P, Shao Y, Luo Y, Li Z, Yang J, Chang Z, Cao R, Li S, Zhong W
Nature communications 2025 May 8;16(1):4298
Nature communications 2025 May 8;16(1):4298
DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases.
Ge R, Chen M, Wu S, Huang S, Zhou P, Cao M, Zhang F, Zang J, Zhu Y, Li J, Ni G, Yang Z, Li Q, Pan W, Zhang L, Liu M, Xuan C, Yu H, Zhou J, Xie S
Nature communications 2025 May 20;16(1):4683
Nature communications 2025 May 20;16(1):4683
The role of JPX in regulating FUS/SLC7A11 signaling pathway mediated ferroptosis in keloid fibroblasts and its potential in scar repair.
Tang J, Huang Z, Yu P
Biochemical and biophysical research communications 2025 May 12;763:151770
Biochemical and biophysical research communications 2025 May 12;763:151770
Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series.
Shneider NA, Harms MB, Korobeynikov VA, Rifai OM, Hoover BN, Harrington EA, Aziz-Zaman S, Singleton J, Jamil A, Madan VR, Lee I, Andrews JA, Smiley RM, Alam MM, Black LE, Shin M, Watts JK, Walk D, Newman D, Pascuzzi RM, Weber M, Neuwirth C, Da Cruz S, Soriano A, Lane R, Henry S, Mathews J, Jafar-Nejad P, Norris D, Rigo F, Brown RH, Miller S, Crean R, Bennett CF
Lancet (London, England) 2025 Jun 7;405(10494):2075-2086
Lancet (London, England) 2025 Jun 7;405(10494):2075-2086
Role of thrombus-derived exosomal lncRNA LOC101928697 in regulating endothelial function via FUS protein interaction in myocardial infarction.
He Y, Liu W, Zhou Y, Ai L, Qian Y, Huang X, Peng L
Science progress 2025 Jul-Sep;108(3):368504251372111
Science progress 2025 Jul-Sep;108(3):368504251372111
M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development.
Huang WP, Kumar V, Yap K, An H, John SJ, Hodgson RE, Avila AS, Day E, Ellis BCS, Chung TH, Lord J, Müller-McNicoll M, Makeyev EV, Shelkovnikova TA
Science advances 2025 Jul 25;11(30):eadx1357
Science advances 2025 Jul 25;11(30):eadx1357
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
Cheng L, Yu H, Qin Y, Wang R, Su T, Lyu G, Huang Z, Li H, Jin Y, Li Y, Wang G
Oncogene 2025 Aug;44(32):2850-2863
Oncogene 2025 Aug;44(32):2850-2863
circLRCH3-FUS interaction stabilizes IFI35 mRNA, inhibiting autophagy and aggravating podocyte pyroptosis in lupus nephritis.
Zhang L, Zhang Z, Zeng Q, Zong Y, Huang J, Xiao B, Chen J, Rao H, Wang H
International immunopharmacology 2025 Aug 28;161:114993
International immunopharmacology 2025 Aug 28;161:114993
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.
Hnath B, Dokholyan NV
bioRxiv : the preprint server for biology 2025 Apr 10;
bioRxiv : the preprint server for biology 2025 Apr 10;
CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.
Liu Y, Jiang H, Hu K, Zou H, Zhang W, Liu J, Jian X
PloS one 2024;19(4):e0298947
PloS one 2024;19(4):e0298947
Patterns of glucose hypometabolism can help differentiate FTLD-FET from other types of FTLD.
Garcia-Guaqueta DP, Ghayal NB, Lowe VJ, Dickson DW, Whitwell JL, Josephs KA
Journal of neurology 2024 Sep;271(9):6264-6273
Journal of neurology 2024 Sep;271(9):6264-6273
Reversal of cognitive deficits in FUS(R521G) amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.
Pelaez MC, Fiore F, Larochelle N, Dabbaghizadeh A, Comaduran MF, Arbour D, Minotti S, Marcadet L, Semaan M, Robitaille R, Nalbantoglu JN, Sephton CF, Durham HD
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00388
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00388
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation.
Zeng X, Tang J, Zhang Q, Wang C, Qi J, Wei Y, Xu J, Yang K, Zhou Z, Wu H, Luo J, Jiang Y, Song Z, Wu J, Wu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2401588
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2401588
Localized synthesis of molecular chaperones sustains neuronal proteostasis.
Alecki C, Rizwan J, Le P, Jacob-Tomas S, Fernandez-Comaduran M, Verbrugghe M, Xu JSM, Minotti S, Lynch J, Biswas J, Wu T, Durham H, Yeo GW, Vera M
bioRxiv : the preprint server for biology 2024 Oct 19;
bioRxiv : the preprint server for biology 2024 Oct 19;
Enhancing diabetic foot ulcer healing: Impact of the regulation of the FUS and ILF2 RNA‑binding proteins through negative pressure wound therapy.
Tang Y, Ji H, Yan Y, Hu D, Xu M, Xu M, Zhao X, Chen M
International journal of molecular medicine 2024 Nov;54(5)
International journal of molecular medicine 2024 Nov;54(5)
Long non-coding RNA MALAT1 triggers ferroptosis via interaction with FUS to enhance ACSF2 mRNA stabilization in septic acute kidney injury.
Duan ZB, Zheng JF, Huang SY, Hu LL
The Kaohsiung journal of medical sciences 2024 Nov;40(11):972-984
The Kaohsiung journal of medical sciences 2024 Nov;40(11):972-984
Virus-modified paraspeckle-like condensates are hubs for viral RNA processing and their formation drives genomic instability.
Harper KL, Harrington EM, Hayward C, Anene CA, Wongwiwat W, White RE, Whitehouse A
Nature communications 2024 Nov 26;15(1):10240
Nature communications 2024 Nov 26;15(1):10240
The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD.
Cicardi ME, Kankate V, Sriramoji S, Krishnamurthy K, Markandaiah SS, Verdone BM, Girdhar A, Nelson A, Rivas LB, Boehringer A, Haeusler AR, Pasinelli P, Guo L, Trotti D
Communications biology 2024 Mar 28;7(1):376
Communications biology 2024 Mar 28;7(1):376
PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer.
Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang YV, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto JJ, Akamatsu H, Napolitano F, Mani R, Cescon DW, Xu L, Xie Y, Mendell JT, Hanker AB, Arteaga CL
Nature communications 2024 Mar 13;15(1):2287
Nature communications 2024 Mar 13;15(1):2287
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.
Fernández Comaduran M, Minotti S, Jacob-Tomas S, Rizwan J, Larochelle N, Robitaille R, Sephton CF, Vera M, Nalbantoglu JN, Durham HD
Cell stress & chaperones 2024 Jun;29(3):359-380
Cell stress & chaperones 2024 Jun;29(3):359-380
TAF15 amyloid filaments in frontotemporal lobar degeneration.
Tetter S, Arseni D, Murzin AG, Buhidma Y, Peak-Chew SY, Garringer HJ, Newell KL, Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B
Nature 2024 Jan;625(7994):345-351
Nature 2024 Jan;625(7994):345-351
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress.
Wang H, Zheng Y, Yu J, Meng L, Zhang W, Hong D, Wang Z, Yuan Y, Deng J
Neurobiology of disease 2024 Jan;190:106391
Neurobiology of disease 2024 Jan;190:106391
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769
Cell reports 2024 Feb 27;43(2):113769
Protein complexes from mouse and chick brain that interact with phospho-KXGS motif tau/microtubule associated protein antibody.
Davies DS, Arthur AT, Aitken HL, Crossett B, Goldsbury CS
Biology open 2024 Feb 15;13(2)
Biology open 2024 Feb 15;13(2)
Neuropathologic findings in a patient with hemiparkinsonism and hemiatrophy syndrome.
Nakamura M, Tsuge A, Miyake K, Kunieda T, Kusaka H, Yakushiji Y
Neuropathology : official journal of the Japanese Society of Neuropathology 2024 Dec;44(6):432-439
Neuropathology : official journal of the Japanese Society of Neuropathology 2024 Dec;44(6):432-439
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
Yang C, Leifer C, Lammerding J, Hu F
The Journal of biological chemistry 2024 Dec;300(12):107999
The Journal of biological chemistry 2024 Dec;300(12):107999
The identification of high-performing antibodies for RNA-binding protein FUS for use in Western Blot, immunoprecipitation, and immunofluorescence.
Alshalfie W, Fotouhi M, Ayoubi R, You Z, Southern K, McPherson PS, Laflamme C, NeuroSGC/YCharOS/EDDU collaborative group
F1000Research 2023;12:376
F1000Research 2023;12:376
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Guo L, Mann JR, Mauna JC, Copley KE, Wang H, Rubien JD, Odeh HM, Lin J, Lee BL, Ganser L, Robinson E, Kim KM, Murthy AC, Paul T, Portz B, Gleixner AM, Diaz Z, Carey JL, Smirnov A, Padilla G, Lavorando E, Espy C, Shang Y, Huang EJ, Chesi A, Fawzi NL, Myong S, Donnelly CJ, Shorter J
bioRxiv : the preprint server for biology 2023 Sep 4;
bioRxiv : the preprint server for biology 2023 Sep 4;
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition.
Ziff OJ, Harley J, Wang Y, Neeves J, Tyzack G, Ibrahim F, Skehel M, Chakrabarti AM, Kelly G, Patani R
Neuron 2023 Oct 4;111(19):3011-3027.e7
Neuron 2023 Oct 4;111(19):3011-3027.e7
Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis.
Wang XL, Li JM, Yuan SQ
Asian journal of andrology 2023 May-Jun;25(3):314-321
Asian journal of andrology 2023 May-Jun;25(3):314-321
The lncRNA Neat1 is associated with astrocyte reactivity and memory deficits in a mouse model of Alzheimer's disease.
Irwin AB, Martina V, Jago SCS, Bahabry R, Schreiber AM, Lubin FD
bioRxiv : the preprint server for biology 2023 May 3;
bioRxiv : the preprint server for biology 2023 May 3;
Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.
Shi WP, Lin WJ, Ge WY, Chen LL, Zhang TD, Guo WH, Liu JL, Yin DC
Food & function 2023 May 22;14(10):4621-4631
Food & function 2023 May 22;14(10):4621-4631
The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD.
Li Y, Geng J, Rimal S, Wang H, Liu X, Lu B, Li S
The Journal of biological chemistry 2023 Mar;299(3):102995
The Journal of biological chemistry 2023 Mar;299(3):102995
Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies.
Koga S, Murakami A, Soto-Beasley AI, Walton RL, Baker MC, Castanedes-Casey M, Josephs KA, Ross OA, Dickson DW
Acta neuropathologica communications 2023 Jul 6;11(1):109
Acta neuropathologica communications 2023 Jul 6;11(1):109
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation.
Uemura MT, Suh ER, Robinson JL, Brunden KR, Grossman M, Irwin DJ, Lee VM, Trojanowski JQ, Lee EB, Van Deerlin VM
Neuropathology and applied neurobiology 2023 Feb;49(1):e12865
Neuropathology and applied neurobiology 2023 Feb;49(1):e12865
Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes.
Tzeplaeff L, Seguin J, Le Gras S, Megat S, Cosquer B, Plassard D, Dieterlé S, Paiva I, Picchiarelli G, Decraene C, Alcala-Vida R, Cassel JC, Merienne K, Dupuis L, Boutillier AL
Progress in neurobiology 2023 Aug;227:102483
Progress in neurobiology 2023 Aug;227:102483
HOTAIRM1 Maintained the Malignant Phenotype of tMSCs Transformed by GSCs via E2F7 by Binding to FUS.
Liu L, Zhou Y, Dong X, Li S, Cheng S, Li H, Li Y, Yuan J, Wang L, Dong J
Journal of oncology 2022;2022:7734413
Journal of oncology 2022;2022:7734413
Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.
Liu F, Huang J, Zhang C, Xie Y, Cao Y, Tao L, Tang H, Lin J, Hammes HP, Huang K, Yi F, Su H, Zhang C
International journal of biological sciences 2022;18(15):5624-5640
International journal of biological sciences 2022;18(15):5624-5640
FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy.
Wu S, Yin Y, Du L
Experimental neurology 2022 Sep;355:114144
Experimental neurology 2022 Sep;355:114144
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease.
Morris M, Moghekar A, Guo H, Pletnikova O, Redding-Ochoa J, Albert M, Resnick SM, Chen L
Acta neuropathologica communications 2022 Nov 14;10(1):164
Acta neuropathologica communications 2022 Nov 14;10(1):164
A toolkit for the identification of NEAT1_2/paraspeckle modulators.
An H, Elvers KT, Gillespie JA, Jones K, Atack JR, Grubisha O, Shelkovnikova TA
Nucleic acids research 2022 Nov 11;50(20):e119
Nucleic acids research 2022 Nov 11;50(20):e119
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Proteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions.
Park H, Yamanaka T, Nukina N
Scientific reports 2022 Mar 14;12(1):4347
Scientific reports 2022 Mar 14;12(1):4347
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564
Nature 2022 Jun;606(7914):557-564
LINC00313 facilitates osteosarcoma carcinogenesis and metastasis through enhancing EZH2 mRNA stability and EZH2-mediated silence of PTEN expression.
Xing CY, Zhang YZ, Hu W, Zhao LY
Cellular and molecular life sciences : CMLS 2022 Jun 25;79(7):382
Cellular and molecular life sciences : CMLS 2022 Jun 25;79(7):382
Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis.
Korben VA, Lyashchenko AK, Blanco-Redondo B, Jafar-Nejad P, Shneider NA
Nature medicine 2022 Jan;28(1):104-116
Nature medicine 2022 Jan;28(1):104-116
Widespread Mislocalization of FUS Is Associated With Mitochondrial Abnormalities in Skeletal Muscle in Amyotrophic Lateral Sclerosis With FUS Mutations.
Yu M, Zhao X, Wu W, Wang Q, Liu J, Zhang W, Yuan Y, Hong D, Wang Z, Deng J
Journal of neuropathology and experimental neurology 2022 Feb 24;81(3):172-181
Journal of neuropathology and experimental neurology 2022 Feb 24;81(3):172-181
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
Iadevaia V, Burke JM, Eke L, Moller-Levet C, Parker R, Locker N
Journal of cell science 2022 Feb 15;135(4)
Journal of cell science 2022 Feb 15;135(4)
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Zhou B, Zheng Y, Li X, Dong H, Yu J, Zou Y, Zhu M, Yu Y, Fang X, Zhou M, Zhang W, Yuan Y, Wang Z, Deng J, Hong D
Molecular neurobiology 2022 Dec;59(12):7265-7277
Molecular neurobiology 2022 Dec;59(12):7265-7277
Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.
Watabe K, Niida-Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, Wakabayashi K, Yamada M, Kakita A, Shibata N
Neuropathology : official journal of the Japanese Society of Neuropathology 2022 Dec;42(6):488-504
Neuropathology : official journal of the Japanese Society of Neuropathology 2022 Dec;42(6):488-504
LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.
Kai H, Wu Q, Yin R, Tang X, Shi H, Wang T, Zhang M, Pan C
Frontiers in cell and developmental biology 2021;9:701628
Frontiers in cell and developmental biology 2021;9:701628
A Deletion of the Nuclear Localization Signal Domain in the Fus Protein Induces Stable Post-stress Cytoplasmic Inclusions in SH-SY5Y Cells.
Notaro A, Messina A, La Bella V
Frontiers in neuroscience 2021;15:759659
Frontiers in neuroscience 2021;15:759659
Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases.
Valori CF, Neumann M
Frontiers in neuroscience 2021;15:724891
Frontiers in neuroscience 2021;15:724891
Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization.
Wu T, Wang G, Zeng X, Sun Z, Li S, Wang W, Yu B
Cell cycle (Georgetown, Tex.) 2021 Sep;20(18):1799-1811
Cell cycle (Georgetown, Tex.) 2021 Sep;20(18):1799-1811
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.
Sanjuan-Ruiz I, Govea-Perez N, McAlonis-Downes M, Dieterle S, Megat S, Dirrig-Grosch S, Picchiarelli G, Piol D, Zhu Q, Myers B, Lee CZ, Cleveland DW, Lagier-Tourenne C, Da Cruz S, Dupuis L
Molecular neurodegeneration 2021 Sep 6;16(1):61
Molecular neurodegeneration 2021 Sep 6;16(1):61
An autopsy case report of neuronal intermediate filament inclusion disease presenting with predominantly upper motor neuron features.
Murakami A, Nakamura M, Nakamura Y, Kaneko S, Yakushiji Y, Kusaka H
Neuropathology : official journal of the Japanese Society of Neuropathology 2021 Oct;41(5):357-365
Neuropathology : official journal of the Japanese Society of Neuropathology 2021 Oct;41(5):357-365
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Xue YC, Ng CS, Mohamud Y, Fung G, Liu H, Bahreyni A, Zhang J, Luo H
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.
Scekic-Zahirovic J, Sanjuan-Ruiz I, Kan V, Megat S, De Rossi P, Dieterlé S, Cassel R, Jamet M, Kessler P, Wiesner D, Tzeplaeff L, Demais V, Sahadevan S, Hembach KM, Muller HP, Picchiarelli G, Mishra N, Antonucci S, Dirrig-Grosch S, Kassubek J, Rasche V, Ludolph A, Boutillier AL, Roselli F, Polymenidou M, Lagier-Tourenne C, Liebscher S, Dupuis L
Nature communications 2021 May 21;12(1):3028
Nature communications 2021 May 21;12(1):3028
Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.
Salam S, Tacconelli S, Smith BN, Mitchell JC, Glennon E, Nikolaou N, Houart C, Vance C
Scientific reports 2021 Jun 30;11(1):13613
Scientific reports 2021 Jun 30;11(1):13613
Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis.
Oyston LJ, Ubiparipovic S, Fitzpatrick L, Hallupp M, Boccanfuso LM, Kwok JB, Dobson-Stone C
Scientific reports 2021 Jul 21;11(1):14881
Scientific reports 2021 Jul 21;11(1):14881
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD
Nature structural & molecular biology 2021 Feb;28(2):132-142
Nature structural & molecular biology 2021 Feb;28(2):132-142
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.
Lin YC, Kumar MS, Ramesh N, Anderson EN, Nguyen AT, Kim B, Cheung S, McDonough JA, Skarnes WC, Lopez-Gonzalez R, Landers JE, Fawzi NL, Mackenzie IRA, Lee EB, Nickerson JA, Grunwald D, Pandey UB, Bosco DA
Nature neuroscience 2021 Aug;24(8):1077-1088
Nature neuroscience 2021 Aug;24(8):1077-1088
LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1.
Xie P, Guo Y
Bioscience reports 2020 Oct 30;40(10)
Bioscience reports 2020 Oct 30;40(10)
Spinal Cord and Motor Neuron TDP-43 Pathology in a Sporadic Inclusion Body Myositis Patient.
Cathcart SJ, Greene EP, Powell SZ, Arumanayagam AS, Rivera AL, Tawil R, Appel SH, Cykowski MD
Journal of neuropathology and experimental neurology 2020 Oct 1;79(10):1130-1133
Journal of neuropathology and experimental neurology 2020 Oct 1;79(10):1130-1133
Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.
Yang Y, Liu X, Zheng J, Xue Y, Liu L, Ma J, Wang P, Yang C, Wang D, Shao L, Ruan X, Liu Y
Molecular oncology 2020 Nov;14(11):2936-2959
Molecular oncology 2020 Nov;14(11):2936-2959
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Han K, Wang FW, Cao CH, Ling H, Chen JW, Chen RX, Feng ZH, Luo J, Jin XH, Duan JL, Li SM, Ma NF, Yun JP, Guan XY, Pan ZZ, Lan P, Xu RH, Xie D
Molecular cancer 2020 Mar 18;19(1):60
Molecular cancer 2020 Mar 18;19(1):60
Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models.
Kuta R, Larochelle N, Fernandez M, Pal A, Minotti S, Tibshirani M, St Louis K, Gentil BJ, Nalbantoglu JN, Hermann A, Durham HD
Cell stress & chaperones 2020 Jan;25(1):173-191
Cell stress & chaperones 2020 Jan;25(1):173-191
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection.
Cabrera JR, Rodríguez-Izquierdo I, Jiménez JL, Muñoz-Fernández MÁ
Journal of neuroinflammation 2020 Dec 7;17(1):371
Journal of neuroinflammation 2020 Dec 7;17(1):371
FUS contributes to mTOR-dependent inhibition of translation.
Sévigny M, Bourdeau Julien I, Venkatasubramani JP, Hui JB, Dutchak PA, Sephton CF
The Journal of biological chemistry 2020 Dec 25;295(52):18459-18473
The Journal of biological chemistry 2020 Dec 25;295(52):18459-18473
All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice.
Zhu Y, Liu Y, Yang F, Chen W, Jiang J, He P, Jiang S, Li M, Xu R
Molecular neurobiology 2020 Aug;57(8):3603-3615
Molecular neurobiology 2020 Aug;57(8):3603-3615
Differential subcellular expression of (P525L)FUS as a putative biomarker for ALS phenoconversion.
Caputo M, La Bella V, Notaro A
Neurology. Genetics 2020 Apr;6(2):e410
Neurology. Genetics 2020 Apr;6(2):e410
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.
López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S
Neuron 2020 Apr 22;106(2):354
Neuron 2020 Apr 22;106(2):354
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A
Cell systems 2020 Apr 22;10(4):333-350.e14
Cell systems 2020 Apr 22;10(4):333-350.e14
Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
Ikenaka K, Ishigaki S, Iguchi Y, Kawai K, Fujioka Y, Yokoi S, Abdelhamid RF, Nagano S, Mochizuki H, Katsuno M, Sobue G
Journal of neuropathology and experimental neurology 2020 Apr 1;79(4):370-377
Journal of neuropathology and experimental neurology 2020 Apr 1;79(4):370-377
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, Rosenbohm A, Sijlmans C, Aly A, Mersmann S, Sanjuan-Ruiz I, Hübers A, Messaddeq N, Wagner M, van Bakel N, Boutillier AL, Ludolph A, Lagier-Tourenne C, Boeckers TM, Dupuis L, Storkebaum E
Nature neuroscience 2019 Nov;22(11):1793-1805
Nature neuroscience 2019 Nov;22(11):1793-1805
Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model.
Rossaert E, Pollari E, Jaspers T, Van Helleputte L, Jarpe M, Van Damme P, De Bock K, Moisse M, Van Den Bosch L
Acta neuropathologica communications 2019 Jul 5;7(1):107
Acta neuropathologica communications 2019 Jul 5;7(1):107
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Baron DM, Matheny T, Lin YC, Leszyk JD, Kenna K, Gall KV, Santos DP, Tischbein M, Funes S, Hayward LJ, Kiskinis E, Landers JE, Parker R, Shaffer SA, Bosco DA
Human molecular genetics 2019 Jul 1;28(13):2143-2160
Human molecular genetics 2019 Jul 1;28(13):2143-2160
FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma.
He Z, Ruan X, Liu X, Zheng J, Liu Y, Liu L, Ma J, Shao L, Wang D, Shen S, Yang C, Xue Y
Journal of experimental & clinical cancer research : CR 2019 Feb 8;38(1):65
Journal of experimental & clinical cancer research : CR 2019 Feb 8;38(1):65
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB
Nature communications 2019 Dec 6;10(1):5583
Nature communications 2019 Dec 6;10(1):5583
Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis.
Shelkovnikova TA, An H, Skelt L, Tregoning JS, Humphreys IR, Buchman VL
Cell reports 2019 Dec 24;29(13):4496-4508.e4
Cell reports 2019 Dec 24;29(13):4496-4508.e4
LINC00473 mediates cyclin D1 expression through a balance between activation and repression signals in breast cancer cells.
Shi X, Wang X
FEBS letters 2019 Apr;593(7):751-759
FEBS letters 2019 Apr;593(7):751-759
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.
Wang H, Guo W, Mitra J, Hegde PM, Vandoorne T, Eckelmann BJ, Mitra S, Tomkinson AE, Van Den Bosch L, Hegde ML
Nature communications 2018 Sep 11;9(1):3683
Nature communications 2018 Sep 11;9(1):3683
Two herpesviral noncoding PAN RNAs are functionally homologous but do not associate with common chromatin loci.
Withers JB, Li ES, Vallery TK, Yario TA, Steitz JA
PLoS pathogens 2018 Nov;14(11):e1007389
PLoS pathogens 2018 Nov;14(11):e1007389
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.
López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S
Neuron 2018 Nov 21;100(4):816-830.e7
Neuron 2018 Nov 21;100(4):816-830.e7
Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases.
Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ
Brain pathology (Zurich, Switzerland) 2018 Mar;28(2):274-283
Brain pathology (Zurich, Switzerland) 2018 Mar;28(2):274-283
Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.
Shelkovnikova TA, Kukharsky MS, An H, Dimasi P, Alexeeva S, Shabir O, Heath PR, Buchman VL
Molecular neurodegeneration 2018 Jun 1;13(1):30
Molecular neurodegeneration 2018 Jun 1;13(1):30
Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.
Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre GK, Lee EB, Lee VMY, Trojanowski JQ, Grossman M
Brain : a journal of neurology 2018 Jan 1;141(1):288-301
Brain : a journal of neurology 2018 Jan 1;141(1):288-301
Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases.
Kahl A, Blanco I, Jackman K, Baskar J, Milaganur Mohan H, Rodney-Sandy R, Zhang S, Iadecola C, Hochrainer K
Scientific reports 2018 Feb 9;8(1):2701
Scientific reports 2018 Feb 9;8(1):2701
Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer.
Xiong D, Wu YB, Jin C, Li JJ, Gu J, Liao YF, Long X, Zhu SQ, Wu HB, Xu JJ, Ding JY
Oncology letters 2018 Aug;16(2):1791-1800
Oncology letters 2018 Aug;16(2):1791-1800
Functional domains of the FSHD-associated DUX4 protein.
Mitsuhashi H, Ishimaru S, Homma S, Yu B, Honma Y, Beermann ML, Miller JB
Biology open 2018 Apr 26;7(4)
Biology open 2018 Apr 26;7(4)
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.
Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J
Cell 2018 Apr 19;173(3):677-692.e20
Cell 2018 Apr 19;173(3):677-692.e20
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.
Cykowski MD, Powell SZ, Appel JW, Arumanayagam AS, Rivera AL, Appel SH
Acta neuropathologica communications 2018 Apr 13;6(1):28
Acta neuropathologica communications 2018 Apr 13;6(1):28
ALS-Related Mutant FUS Protein Is Mislocalized to Cytoplasm and Is Recruited into Stress Granules of Fibroblasts from Asymptomatic FUS P525L Mutation Carriers.
Lo Bello M, Di Fini F, Notaro A, Spataro R, Conforti FL, La Bella V
Neuro-degenerative diseases 2017;17(6):292-303
Neuro-degenerative diseases 2017;17(6):292-303
Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs.
Lyons SM, Gudanis D, Coyne SM, Gdaniec Z, Ivanov P
Nature communications 2017 Oct 24;8(1):1127
Nature communications 2017 Oct 24;8(1):1127
Novel miR-b2122 regulates several ALS-related RNA-binding proteins.
Hawley ZCE, Campos-Melo D, Strong MJ
Molecular brain 2017 Oct 2;10(1):46
Molecular brain 2017 Oct 2;10(1):46
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
Tibshirani M, Zhao B, Gentil BJ, Minotti S, Marques C, Keith J, Rogaeva E, Zinman L, Rouaux C, Robertson J, Durham HD
Human molecular genetics 2017 Nov 1;26(21):4142-4152
Human molecular genetics 2017 Nov 1;26(21):4142-4152
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Shelkovnikova TA, Dimasi P, Kukharsky MS, An H, Quintiero A, Schirmer C, Buée L, Galas MC, Buchman VL
Cell death & disease 2017 May 11;8(5):e2788
Cell death & disease 2017 May 11;8(5):e2788
Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.
Scekic-Zahirovic J, Oussini HE, Mersmann S, Drenner K, Wagner M, Sun Y, Allmeroth K, Dieterlé S, Sinniger J, Dirrig-Grosch S, René F, Dormann D, Haass C, Ludolph AC, Lagier-Tourenne C, Storkebaum E, Dupuis L
Acta neuropathologica 2017 Jun;133(6):887-906
Acta neuropathologica 2017 Jun;133(6):887-906
Molecular determinants of cytochrome C oxidase IV mRNA axonal trafficking.
Kar AN, Vargas JNS, Chen CY, Kowalak JA, Gioio AE, Kaplan BB
Molecular and cellular neurosciences 2017 Apr;80:32-43
Molecular and cellular neurosciences 2017 Apr;80:32-43
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.
Yasuda K, Clatterbuck-Soper SF, Jackrel ME, Shorter J, Mili S
The Journal of cell biology 2017 Apr 3;216(4):1015-1034
The Journal of cell biology 2017 Apr 3;216(4):1015-1034
Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules.
Muresan V, Ladescu Muresan Z
Neuro-degenerative diseases 2016;16(1-2):55-61
Neuro-degenerative diseases 2016;16(1-2):55-61
Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.
Van den Bossche T, Sleegers K, Cuyvers E, Engelborghs S, Sieben A, De Roeck A, Van Cauwenberghe C, Vermeulen S, Van den Broeck M, Laureys A, Peeters K, Mattheijssens M, Vandenbulcke M, Vandenberghe R, Martin JJ, De Deyn PP, Cras P, Van Broeckhoven C, Belgian Neurology Consortium
Neurology 2016 Jun 7;86(23):2126-33
Neurology 2016 Jun 7;86(23):2126-33
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Kapeli K, Pratt GA, Vu AQ, Hutt KR, Martinez FJ, Sundararaman B, Batra R, Freese P, Lambert NJ, Huelga SC, Chun SJ, Liang TY, Chang J, Donohue JP, Shiue L, Zhang J, Zhu H, Cambi F, Kasarskis E, Hoon S, Ares M Jr, Burge CB, Ravits J, Rigo F, Yeo GW
Nature communications 2016 Jul 5;7:12143
Nature communications 2016 Jul 5;7:12143
Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis.
Lim SM, Choi WJ, Oh KW, Xue Y, Choi JY, Kim SH, Nahm M, Kim YE, Lee J, Noh MY, Lee S, Hwang S, Ki CS, Fu XD, Kim SH
Molecular neurodegeneration 2016 Jan 22;11:8
Molecular neurodegeneration 2016 Jan 22;11:8
Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4.
Homma S, Beermann ML, Yu B, Boyce FM, Miller JB
Skeletal muscle 2016 Dec 1;6(1):42
Skeletal muscle 2016 Dec 1;6(1):42
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
Chen Y, Deng J, Wang P, Yang M, Chen X, Zhu L, Liu J, Lu B, Shen Y, Fushimi K, Xu Q, Wu JY
Human molecular genetics 2016 Dec 1;25(23):5059-5068
Human molecular genetics 2016 Dec 1;25(23):5059-5068
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM
Frontiers in cellular neuroscience 2015;9:496
Frontiers in cellular neuroscience 2015;9:496
A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency.
He J, Huang L, Qiu H, Li J, Luo L, Li Y, Tian S, Kang K, Luo J, Liu L, Gou D
Cell & bioscience 2015;5:67
Cell & bioscience 2015;5:67
Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.
Robinson HK, Deykin AV, Bronovitsky EV, Ovchinnikov RK, Ustyugov AA, Shelkovnikova TA, Kukharsky MS, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Bachurin SO, Buchman VL, Ninkina NN
Amyotrophic lateral sclerosis & frontotemporal degeneration 2015;16(5-6):402-9
Amyotrophic lateral sclerosis & frontotemporal degeneration 2015;16(5-6):402-9
ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation.
King A, Troakes C, Smith B, Nolan M, Curran O, Vance C, Shaw CE, Al-Sarraj S
Acta neuropathologica communications 2015 Oct 9;3:62
Acta neuropathologica communications 2015 Oct 9;3:62
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R
Molecular and cellular biology 2015 Jul;35(14):2385-99
Molecular and cellular biology 2015 Jul;35(14):2385-99
Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.
Tibshirani M, Tradewell ML, Mattina KR, Minotti S, Yang W, Zhou H, Strong MJ, Hayward LJ, Durham HD
Human molecular genetics 2015 Feb 1;24(3):773-86
Human molecular genetics 2015 Feb 1;24(3):773-86
Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells.
Acosta JR, Goldsbury C, Winnick C, Badrock AP, Fraser ST, Laird AS, Hall TE, Don EK, Fifita JA, Blair IP, Nicholson GA, Cole NJ
PloS one 2014;9(6):e90572
PloS one 2014;9(6):e90572
PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.
Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Netherlands Brain Bank, Bakker EB, International Parkinsonism Genetics Network, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J
Brain : a journal of neurology 2014 May;137(Pt 5):1361-73
Brain : a journal of neurology 2014 May;137(Pt 5):1361-73
Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.
Smets K, Deconinck T, Baets J, Sieben A, Martin JJ, Smouts I, Wang S, Taroni F, Di Bella D, Van Hecke W, Parizel PM, Jadoul C, De Potter R, Couvreur F, Rugarli E, De Jonghe P
Neurology 2014 Jun 10;82(23):2092-100
Neurology 2014 Jun 10;82(23):2092-100
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M, Caldecott KW
Nucleic acids research 2014 Jan;42(1):307-14
Nucleic acids research 2014 Jan;42(1):307-14
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.
Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, Degroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao FB
Acta neuropathologica 2013 Sep;126(3):385-99
Acta neuropathologica 2013 Sep;126(3):385-99
Atypical FTLD-FUS associated with ALS-TDP: a case report.
Kobayashi Z, Arai T, Yokota O, Tsuchiya K, Hosokawa M, Oshima K, Niizato K, Akiyama H, Mizusawa H
Neuropathology : official journal of the Japanese Society of Neuropathology 2013 Feb;33(1):83-6
Neuropathology : official journal of the Japanese Society of Neuropathology 2013 Feb;33(1):83-6
Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases.
Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H
Journal of the neurological sciences 2013 Dec 15;335(1-2):89-95
Journal of the neurological sciences 2013 Dec 15;335(1-2):89-95
Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.
Kwan JY, Jeong SY, Van Gelderen P, Deng HX, Quezado MM, Danielian LE, Butman JA, Chen L, Bayat E, Russell J, Siddique T, Duyn JH, Rouault TA, Floeter MK
PloS one 2012;7(4):e35241
PloS one 2012;7(4):e35241
Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain.
Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Katsuse O, Togo T, Hirayasu Y, Akiyama H
Acta neuropathologica 2012 Sep;124(3):383-94
Acta neuropathologica 2012 Sep;124(3):383-94
p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions.
Tanji K, Zhang HX, Mori F, Kakita A, Takahashi H, Wakabayashi K
Journal of neuroscience research 2012 Oct;90(10):2034-42
Journal of neuroscience research 2012 Oct;90(10):2034-42
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations.
Snowden JS, Rollinson S, Thompson JC, Harris JM, Stopford CL, Richardson AM, Jones M, Gerhard A, Davidson YS, Robinson A, Gibbons L, Hu Q, DuPlessis D, Neary D, Mann DM, Pickering-Brown SM
Brain : a journal of neurology 2012 Mar;135(Pt 3):693-708
Brain : a journal of neurology 2012 Mar;135(Pt 3):693-708
Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.
Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jun 13;32(24):8270-83
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jun 13;32(24):8270-83
Optineurin is colocalized with ubiquitin in Marinesco bodies.
Schwab C, Yu S, McGeer PL
Acta neuropathologica 2012 Feb;123(2):289-92
Acta neuropathologica 2012 Feb;123(2):289-92
Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase.
Farg MA, Soo KY, Walker AK, Pham H, Orian J, Horne MK, Warraich ST, Williams KL, Blair IP, Atkin JD
Neurobiology of aging 2012 Dec;33(12):2855-68
Neurobiology of aging 2012 Dec;33(12):2855-68
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
van Eersel J, Ke YD, Gladbach A, Bi M, Götz J, Kril JJ, Ittner LM
PloS one 2011;6(7):e22850
PloS one 2011;6(7):e22850
Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.
Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D
Glia 2011 Nov;59(11):1719-31
Glia 2011 Nov;59(11):1719-31
Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.
Deng HX, Bigio EH, Zhai H, Fecto F, Ajroud K, Shi Y, Yan J, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T
Archives of neurology 2011 Aug;68(8):1057-61
Archives of neurology 2011 Aug;68(8):1057-61
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, Bigio EH, Brooks BR, Ajroud K, Sufit RL, Haines JL, Mugnaini E, Pericak-Vance MA, Siddique T
Nature 2011 Aug 21;477(7363):211-5
Nature 2011 Aug 21;477(7363):211-5
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Shan X, Chiang PM, Price DL, Wong PC
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 14;107(37):16325-30
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 14;107(37):16325-30
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T
Annals of neurology 2010 Jun;67(6):739-48
Annals of neurology 2010 Jun;67(6):739-48
FUS pathology in basophilic inclusion body disease.
Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie IR
Acta neuropathologica 2009 Nov;118(5):617-27
Acta neuropathologica 2009 Nov;118(5):617-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11570-1-AP(FUS antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using FUS antibody 11570-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FUS (IP:11570-1-AP, 3ug; Detection:11570-1-AP 1:1000) with K-562 cells lysate 4000ug.
- Sample type
- cell line
