CYP2D6

gene product
CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, P450-DB1, P450C2D
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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597 antibodies from 35 providers.

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Antibody
Proteintech Group
2 antibodies
Invitrogen Antibodies
11 antibodies
Novus Biologicals
7 antibodies
Affinity Biosciences
5 antibodies
Boster Biological Technology
4 antibodies
antibodies-online
231 antibodies
NovoPro Bioscience Inc.
4 antibodies
LifeSpan BioSciences, Inc.
91 antibodies
Aviva Systems Biology
11 antibodies
Biorbyt
55 antibodies
OriGene
11 antibodies
Abnova Corporation
8 antibodies
NSJ Bioreagents
4 antibodies
Abgent
2 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
3 antibodies
GeneTex
8 antibodies
St John's Laboratory
8 antibodies
Abbexa
9 antibodies
ProSci
2 antibodies
Antibodies.com
1 antibody
Cell Signaling Technology, Inc
1 antibody
Abbkine Scientific Co.Ltd.
6 antibodies
Acris Antibodies GmbH
8 antibodies
RabMAbs
2 antibodies
Creative Biolabs
8 antibodies
MyBioSource
12 antibodies
Creative Diagnostics
6 antibodies
United States Biological
50 antibodies
Enzo Life Sciences
2 antibodies
GenWay
3 antibodies
Leading Biology
2 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
1 antibody