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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [13]
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- Product number
- 66937-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- UBR5 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated UBR5 antibody (Cat. #66937-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2E7A6
- Vial size
- 20ul, 150ul
Submitted references UBR5 regulates the progression of colorectal cancer cells through Snail-induced epithelial-mesenchymal transition.
The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT.
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7.
HERC5-mediated ISGylation of SARS-CoV-2 nsp8 facilitates its degradation and inhibits viral replication.
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.
Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Multiple E3 ligases act as antiviral factors against SARS-CoV-2 via inducing the ubiquitination and degradation of ORF9b.
Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex.
Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection.
CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9.
Zhao X, Liu R, Han Z, Li Z, Mei L, Liu Y, Fu X, Jin Y
Genes & diseases 2026 Mar;13(2):101679
Genes & diseases 2026 Mar;13(2):101679
The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT.
Liao L, Xu Q, Xu J, Chen J, Liu W, Chen W, Tang Y, Duan L, Guo Y, Liu Z, Tao P, Cao Y, Lu J, Hu J
Acta diabetologica 2025 Sep;62(9):1403-1416
Acta diabetologica 2025 Sep;62(9):1403-1416
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
Baehr LM, de Sousa LGO, Goodman CA, Sharples AP, Waddell DS, Bodine SC, Hughes DC
bioRxiv : the preprint server for biology 2025 Oct 2;
bioRxiv : the preprint server for biology 2025 Oct 2;
SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7.
Tian L, Zhao Z, Gao W, Liu Z, Li X, Zhang W, Li Z
eLife 2025 May 13;13
eLife 2025 May 13;13
HERC5-mediated ISGylation of SARS-CoV-2 nsp8 facilitates its degradation and inhibits viral replication.
Hou Y, Shi H, Wang H, Tian L, Huan C, Liu Y, Wang H, Zhang W
International journal of biological macromolecules 2025 Jun;315(Pt 2):144546
International journal of biological macromolecules 2025 Jun;315(Pt 2):144546
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
Baehr LM, Oliveira de Sousa LG, Goodman CA, Sharples AP, Waddell DS, Bodine SC, Hughes DC
American journal of physiology. Cell physiology 2025 Dec 1;329(6):C1706-C1722
American journal of physiology. Cell physiology 2025 Dec 1;329(6):C1706-C1722
VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.
Zhu C, Cheng Y, Yu Y, Zhang Y, Ren G
Biomolecules & biomedicine 2024 Sep 6;24(5):1244-1257
Biomolecules & biomedicine 2024 Sep 6;24(5):1244-1257
Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
Han T, Wang Y, Cheng M, Hu Q, Wan X, Huang M, Liu Y, Xun W, Xu J, Wang L, Luo R, Yuan Y, Wang K, Wang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Qi H, Yu M, Fan X, Zhou Y, Zhang M, Gao X
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Multiple E3 ligases act as antiviral factors against SARS-CoV-2 via inducing the ubiquitination and degradation of ORF9b.
Yu M, Li J, Gao W, Li Z, Zhang W
Journal of virology 2024 Jun 13;98(6):e0162423
Journal of virology 2024 Jun 13;98(6):e0162423
Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex.
Zhang J, Gao H, Jiang N, Jing M, Sun Z, Du C, Zhang J, Wang M, Li J, Gao F, Hu Y, Mu H, Cui X
Experimental eye research 2022 Jul;220:109110
Experimental eye research 2022 Jul;220:109110
Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection.
Gestuveo RJ, Royle J, Donald CL, Lamont DJ, Hutchinson EC, Merits A, Kohl A, Varjak M
Nature communications 2021 May 13;12(1):2766
Nature communications 2021 May 13;12(1):2766
CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9.
Zhang Y, Hou J, Shi S, Du J, Liu Y, Huang P, Li Q, Liu L, Hu H, Ji Y, Guo L, Shi Y, Liu Y, Cui H
Cell death & disease 2021 Jan 22;12(1):118
Cell death & disease 2021 Jan 22;12(1):118
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