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Western blotAntibody data
- Antibody Data
- Antigen structure
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- Product number
- orb67040 - Provider product page
- Provider
- Biorbyt
- Product name
- FZD8 antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal to FZD8.Frizzled-8 (FZD8) is a receptor for Wnt proteins, which belongs to the G-protein coupled receptorFz/Smo family. FZD8 is a component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-cateninsignaling through inducing aggregation of receptor-ligand complexes into ribosome-sizedsignalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveledproteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt targetgenes. A second signaling pathway involving PKC and calcium fluxes has been seen for some familymembers. FZD8 may be involved in transduction and intercellular transmission of polarity informationduring tissue morphogenesis and/or in differentiated tissues.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 100 ul
- Storage
- -20°C
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