ZNF408

The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and retinitis pigmentosa (RP). [provided by RefSeq, Dec 2016]

Description

Zinc finger protein 408

Tissue specificity

Low tissue specificity

Subcell location

Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

11 (46701030 - 46705912)

Ensembl ID

ENSG00000175213  (ver. 103.38)

Orthologs

Mouse Zfp408: ENSMUSG00000075040

UniProt

Q9H9D4

neXtProt

NX_Q9H9D4

Human splice variants
Mouse splice variants

Protein structure