19272-1-AP

antibody from Proteintech Group

Targeting: TNFRSF1B CD120b, p75, TNF-R-II, TNF-R75, TNFBR, TNFR2, TNFR80

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

19272-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#19272-1-AP, RRID:AB_10640674

Product name

TNFR2 antibody

Antibody type

Polyclonal

Description

KD/KO validated TNFR2 antibody (Cat. #19272-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Unveiling the mechanisms of trichloroethylene hypersensitivity syndrome: Exploring the role of connexin 43 gap junctions in severe skin damage.

Jiao B, Jiang H, Liu S, Wang Y, Chen Y, Duan H, Niu Y, Shen M, Wang H, Dai Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114594

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Na(v)1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.

Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo EX, Samuels J, Hu W, Attur M, Waxman SG, Liu CJ
Nature 2024 Jan;625(7995):557-565

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Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis.

Xiao B, Jiang Y, Yuan S, Cai L, Xu T, Jia L
MedComm 2024 Jan;5(1):e457

---

Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis.

Nguyen KL, Bhatt IJ, Gupta S, Showkat N, Swanson KA, Fischer R, Kontermann RE, Pfizenmaier K, Bracchi-Ricard V, Bethea JR
Brain research bulletin 2024 Feb;207:110885

---

PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis.

Zhang L, Nie F, Zhao J, Li S, Liu W, Guo H, Yang P
Journal of translational medicine 2024 Apr 30;22(1):407

---

Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome.

Jiao B, Zhang H, Jiang H, Liu S, Wang Y, Chen Y, Duan H, Niu Y, Shen M, Wang H, Dai Y
Ecotoxicology and environmental safety 2024 Apr 1;274:116174

---

Inducible nitric oxide synthase activity mediates TNF-α-induced endothelial cell dysfunction.

Liu C, Lei S, Cai T, Cheng Y, Bai J, Fu W, Huang M
American journal of physiology. Cell physiology 2023 Sep 1;325(3):C780-C795

---

Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis.

Wang J, Hu D, Chen Q, Liu T, Zhou X, Xu Y, Zhou H, Gu D, Gao C
Materials today. Bio 2023 Jun;20:100679

---

Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis.

Zhang L, Li L, Chen X, Yuan S, Xu T, Zhao W, Li M, Wang F, Hoffman RM, Jia L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154493

---

Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis.

Yuan S, Pan Y, Xu T, Zhang L, Chen X, Wang F, Liu Q, Jia L
Oxidative medicine and cellular longevity 2022;2022:5382263

---

Identification of Biomarkers Related to Regulatory T Cell Infiltration in Oral Squamous Cell Carcinoma Based on Integrated Bioinformatics Analysis.

Wang C, Chen Z, Yang X, Zhang W, Zhou J, Zhang H, Ding X, Ye J, Wu H, Wu Y, Zheng Y, Song X
International journal of general medicine 2022;15:2361-2376

---

Tumor necrosis factor alpha delivers exogenous inflammation-related microRNAs to recipient cells with functional targeting capabilities.

Zhao Y, Zhang T, Shen X, Huang A, Li H, Wang L, Liu X, Wang X, Song X, Wang S, Dong J, Shao N
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Sep 7;30(9):3052-3065

---

TNFα-induced abnormal activation of TNFR/NF-κB/FTH1 in endometrium is involved in the pathogenesis of early spontaneous abortion.

Wen Y, Cheng M, Qin L, Xu W
Journal of cellular and molecular medicine 2022 May;26(10):2947-2958

---

The Impact of β-1,4-Galactosyltransferase V on Microglial Function.

Wang X, Shi N, Hui M, Jin H, Gao S, Zhou Q, Zhang L, Yan M, Shen H
Frontiers in cellular neuroscience 2021;15:723308

---

Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension.

Wang F, Sun C, Lv X, Sun M, Si C, Zhen Y, Guo J, Sun W, Ye Z, Wen J, Liu P
Frontiers in physiology 2021;12:744219

---

Effect of pyrroloquinoline quinone on lipopolysaccharide-induced autophagy in HAPI microglia cells.

Gao S, Zhou Q, Jin H, Shi N, Wang X, Zhang L, Yan M
Annals of translational medicine 2021 Sep;9(17):1377

---

LncRNA NEAT1 mediates intestinal inflammation by regulating TNFRSF1B.

Pan S, Liu R, Wu X, Ma K, Luo W, Nie K, Zhang C, Meng X, Tong T, Chen X, Wang X, Deng M
Annals of translational medicine 2021 May;9(9):773

---

Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.

Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548

---

In vitro Evaluation of the Safety of Adalimumab for the Eye Under HTLV-1 Infection Status: A Preliminary Study.

Kurozumi-Karube H, Kamoi K, Ando N, Uchida M, Hamaguchi I, Ohno-Matsui K
Frontiers in microbiology 2020;11:522579

---

KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.

Wang B, Jing T, Jin W, Chen J, Wu C, Wang M, Liu Y
Journal of experimental & clinical cancer research : CR 2020 Aug 27;39(1):170

---

EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation.

Zhang Y, Yang C, Ge S, Wang L, Zhang J, Yang P
BMC molecular and cell biology 2020 Apr 16;21(1):29

---

Safety of Infliximab for the Eye Under Human T-Cell Leukemia Virus Type 1 Infectious Conditions in vitro.

Uchida M, Kamoi K, Ando N, Wei C, Karube H, Ohno-Matsui K
Frontiers in microbiology 2019;10:2148

---

Expression of tumor necrosis factor receptor 2 in human non-small cell lung cancer and its role as a potential prognostic biomarker.

Zhang YW, Chen QQ, Cao J, Xu LQ, Tang X, Wang J, Zhang J, Dong LX
Thoracic cancer 2019 Mar;10(3):437-444

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Progranulin Promotes Regeneration of Inflammatory Periodontal Bone Defect in Rats via Anti-inflammation, Osteoclastogenic Inhibition, and Osteogenic Promotion.

Chen Q, Cai J, Li X, Song A, Guo H, Sun Q, Yang C, Yang P
Inflammation 2019 Feb;42(1):221-234

---

Clinical significance of tumor necrosis factor receptor 2 in middle and lower thoracic esophageal squamous cell carcinoma.

Yang D, Li R, Wang H, Wang J, Li Y, Wang H, Wang W, Liu Z
Oncology letters 2018 Sep;16(3):2971-2978

---

High expression of tumor necrosis factor receptor 2 in tissue is associated with progression and prognosis of esophageal squamous cell carcinoma.

Liu Z, Ma C, Ma G, Sun X, Liu J, Li S, Liu K, Wang J, Yang D
Human pathology 2018 Oct;80:179-185

---

NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death.

Huang D, Chen J, Yang L, Ouyang Q, Li J, Lao L, Zhao J, Liu J, Lu Y, Xing Y, Chen F, Su F, Yao H, Liu Q, Su S, Song E
Nature immunology 2018 Oct;19(10):1112-1125

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Tumor necrosis factor receptor 2 may promote the proliferation and drug resistance of Kapras299 and L428 lymphoma cells via the AKT and WNT/β-catenin signaling pathways.

Liang Y, Wang Y, Xiao M, Hao Y, Zhang Y, Li S
Oncology letters 2018 Jun;15(6):8847-8852

---

Lymphotoxins Promote the Progression of Human Lymphatic Malformation by Enhancing Lymphatic Endothelial Cell Proliferation.

Yang JG, Sun YF, He KF, Ren JG, Liu ZJ, Liu B, Zhang W, Zhao YF
The American journal of pathology 2017 Nov;187(11):2602-2615

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Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters 2017 Nov 1;408:60-70

---

Tumor necrosis factor receptor 2 promotes growth of colorectal cancer via the PI3K/AKT signaling pathway.

Zhao T, Li H, Liu Z
Oncology letters 2017 Jan;13(1):342-346

---

Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy.

Fukui S, Nakamura H, Takahashi Y, Iwamoto N, Hasegawa H, Yanagihara K, Nakamura T, Okayama A, Kawakami A
BMC immunology 2017 Feb 3;18(1):7

---

Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells.

Molino Y, Jabès F, Bonnet A, Gaudin N, Bernard A, Benech P, Khrestchatisky M
Journal of neuroinflammation 2016 Nov 10;13(1):290

---

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Kallenborn-Gerhardt W, Hohmann SW, Syhr KM, Schröder K, Sisignano M, Weigert A, Lorenz JE, Lu R, Brüne B, Brandes RP, Geisslinger G, Schmidtko A
Pain 2014 Oct;155(10):2161-70

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Jurkat cells were subjected to SDS PAGE followed by western blot with 19272-1-AP(TNFR2 antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using TNFRSF1B antibody 19272-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human spleen using 19272-1-AP(TNFR2 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human spleen using 19272-1-AP(TNFR2 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The TNFR2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TNFR2. This antibody recognizes human, mouse antigen. The TNFR2 antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.

Appendix

19272-1-AP.pdf

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