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TNFRSF1B
TNF receptor superfamily member 1BCD120b, p75, TNF-R-II, TNF-R75, TNFBR, TNFR2, TNFR80
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  19272-1-AP |
19 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | MA5-32618 |
2 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| Novus Biologicals | AF-426-PB |
7 references | Polyclonal |
WB
EL
ICC
FC
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| R&D Systems | AF-426-PB |
7 references | Polyclonal |
WB
EL
ICC
FC
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| OriGene | AM26345FC-N |
Monoclonal |
WB
EL
IP
IHC
FC
FA
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