NBP2-47827JF646

antibody from Novus Biologicals
Targeting: CDH1 CD324, UVO, uvomorulin
Provider product page for NBP2-47827JF646
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NBP2-47827JF646 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal E-Cadherin Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as E-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Reactivity
Human
Host
Mouse
Isotype
IgG
Vial size
0.1 ml
Storage
Store at 4C in the dark.
CDH1 protein structure - NBP2-47827JF646 shown in red.